Optimization of Synthesis Parameters for Mesoporous Shell Formation on Magnetic Nanocores and Their Application as Nanocarriers for Docetaxel Cancer Drug

Abstract

In this work, Fe3O4@SiO2 nanoparticles were coated with mesoporous silica shell by S−N+I− pathway by using anionic surfactant (S−) and co-structure directing agent (N+). The role of co-structure directing agent (CSDA) is to assist the electrostatic interaction between negatively charged silica layers and the negatively charged surfactant molecules. Prior to the mesoporous shell formation step, magnetic cores were coated with a dense silica layer to prevent iron oxide cores from leaching into the mother system under any acidic circumstances. However, it was found that both dense and mesoporous coating parameters affect the textural properties of the produced mesoporous silica shell (i.e., surface area, pore volume and shell thickness). The synthesized Fe3O4@SiO2@m-SiO2 (MCMSS) nanoparticles have been characterized by low-angle X-ray diffraction, transmission electron microscopy (TEM), and N2 adsorption-desorption analysis, and magnetic properties. The synthesized particles had dense and mesoporous silica shells of 8–37 nm and 26–50 nm, respectively. Furthermore, MCMSS possessed surface area of ca. 259–621 m2·g−1, and pore volume of ca. 0.216–0.443 cc·g−1. MCMSS showed docetaxcel cancer drug storage capacity of 25–33 w/w% and possessed control release from their mesochannels which suggest them as proper nanocarriers for docetaxcel molecules.

Spray Deposition of Titania Films with Incorporated Crystalline Nanoparticles for All‐Solid‐State Dye‐Sensitized Solar Cells Using P3HT

“…According to IUPAC classification, all isotherms are identified as the adsorption and desorption branch of a type IV curve, indicating the existence of mesopores. All hysteresis loops are categorized as the type H 1 loop, implying a high degree of pore‐size uniformity in the titania films . The textural parameters derived from the isotherms are comprised in Table 1 .…”

Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances

“…When they provided Na 2 HPO 4 -NaH 2 PO 4 as a source of OH − ions, particle size was found to increase with an increase in the initial pH of the solution. El-Toni et al observed that on increasing the concentration of ammonia beyond a certain level, the agglomeration of silica particles takes place due to the increase in the ionic strength of the reaction medium [ 113 ]. Bouchoucha et al also reported the efficiency of TEA in producing well-dispersed nanoparticles [ 114 ].…”

Recent advances in stimuli-responsive drug release and targeting concepts using mesoporous silica nanoparticles

“…The more likely properties of MSNs that tailor the biomedical performance in terms of drug or gene loading and their release are particle size, pore size, and volume. For instance, relatively smaller particle sizes were obtained using some reagents, including alcohols, amines, inorganic bases, and inorganic salts [26][27][28]. Those agents affect the kinetics of hydrolysis and condensation reactions of the silica precursor.…”