Optimization of surface plasmon resonance-based biosensors for monitoring hemoglobin levels in human blood

Keshavarz, Alireza; Zangenehzadeh, Soraya; Hatef, Ali

doi:10.1007/s13204-020-01252-x

Cited by 16 publications

(7 citation statements)

References 20 publications

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“…Popescu et al [ 44 ] 2019 SPR 1530 – 0.0036 g/dl A.K. Goyal et al [ 35 ] 2020 BSW 380 0.0133 °/gl −1 and 69 °/RIU – A. Keshavarz [ 2 ] 2020 SPR 632.8 235.24 °/RIU – Proposed work SPR 632.8 303.83°/RIU and 0.045 °/gl −1 0.021 g/l …”

Section: Resultsmentioning

confidence: 99%

“…The RI sensitivity (S R ) and concentration sensitivity (S C ) of the SPR biosensor can be calculated using Eqs. [ 2 , 14 , 15 , 35 ], …”

Section: Modeling and Performance Parameters Of The Spr Biosensormentioning

confidence: 99%

“…Each chain possesses iron containing pigment (heme) essential for rapid binding of molecular oxygen [ 1 ]. It plays a fundamental role in transporting molecular oxygen in the blood of vertebrates, from respiratory organs to the rest of the tissues and the organs [ 2 ]. The levels of Hb in blood in terms of shortage and saturation are the major biomarkers of diseases [ 3 ] such as anemia [ 4 ], leukemia, heart diseases [ 5 ] and hemoglobinuria [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…In 2016, Mohanty et al have analyzed effect of nitrides in graphene-based SPR biosensor for the detection of hemoglobin, to enhance the concentration sensitivity (S c ) and resolution up to 0.286°/gdl −1 or (0.0286°/gl −1 ) and 0.00350 g/dl or (0.035 g/l), respectively [ 17 ]. Recently, Keshavarz et al used Au/graphene/WS 2 SPR configuration for the monitoring the Hb level in human blood with maximum RI sensitivity (S R ) of 235.24°/RIU [ 2 ]. The 2D nanomaterial graphene and WS 2 were used to enhance the sensitivity of SPR biosensor.…”

Section: Introductionmentioning

confidence: 99%

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A nanolayered structure for sensitive detection of hemoglobin concentration using surface plasmon resonance

et al. 2021

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The objective of the proposed work is to design a biosensor that monitors hemoglobin (Hb) concentration using the combination of nanolayer, i.e., barium titanate (BaTiO 3 ) and antimonene based on surface plasmon resonance (SPR) technique. Antimonene is used here as bio-recognition element (BRE) layer to attach the Hb analyte through physical adsorption due to its hydrophilic nature, higher adsorption energy and larger active surface area. The use of BaTiO 3 adlayer (7 nm) just before antimonene is to enhance the refractive index (RI) sensitivity up to 1.90 times for the proposed SPR biosensor. The reason behind sensitivity enhancement is its high dielectric constant which enhances the electromagnetic field with in analyte medium. The performance of the biosensor is demonstrated with performance parameters namely sensitivity, detection accuracy (DA), figure of merit (FOM) and resolution. The proposed biosensor has potential to achieve much higher performance in terms of RI sensitivity of 303.83°/RIU, FOM of 50.39 RIU −1 and resolution of 0.021 g/l in comparison with reported biosensors in the literature for detection of Hb concentration. Thus, based on the obtained results one can say that the proposed work unlocks a reliable sensing in the field of medical science to detect hemoglobin-related diseases in human being.

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Section: Resultsmentioning

confidence: 99%

“…The RI sensitivity (S R ) and concentration sensitivity (S C ) of the SPR biosensor can be calculated using Eqs. [ 2 , 14 , 15 , 35 ], …”

Section: Modeling and Performance Parameters Of The Spr Biosensormentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A nanolayered structure for sensitive detection of hemoglobin concentration using surface plasmon resonance

et al. 2021

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“…The gold over silicon was employed to decrease the FWHM to 0.745° but overall sensitivity was decrease to 0.0028°/ (g/L) (Brahmachari and Ray 2016). Recently in 2020, Keshavarz et al (2020) used substrate/Au/Graphene/WS 2 structure for haemoglobin concentration measurement and reported an average sensitivity of 235.24°/RIU along with 10.16° FWHM. The most of the mentioned work exhibits very high FWHM that affects the sensor resolution.…”

Section: Introductionmentioning

confidence: 99%

Design analysis of Bloch surface wave based sensor for haemoglobin concentration measurement

Goyal

Pal

2020

Appl Nanosci

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In this paper, a Bloch Surface Waves (BSW) based sensor is proposed to estimate the haemoglobin concentration in human blood. The behaviour of the sensor is analysed using a transfer matrix method. The proposed structure is designed considering one-dimensional photonic crystal, where a defective top layer is deliberately introduced to confine a surface plasmon-like mode called Bloch mode at the top interface. The effective refractive index of top interface changes along with haemoglobin concentration. Thereby, monitoring the angel of incidence to confine BSW mode can helps in determining the haemoglobin concentration. The sensing capability, FWHM and figure-of-merit of the proposed structure are improved by optimizing the defect layer thicknesses, incident angels and wavelengths. Proposed structure shows an average FWHM and average sensitivity of around 0.00508 and 0.0133°/(g/L) respectively.

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Sensitivity enhancement with anti-reflection coating of silicon nitride (Si3N4) layer in silver-based Surface Plasmon Resonance (SPR) sensor for sensing of DNA hybridization

et al. 2020

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Optimization of surface plasmon resonance-based biosensors for monitoring hemoglobin levels in human blood

Cited by 16 publications

References 20 publications

A nanolayered structure for sensitive detection of hemoglobin concentration using surface plasmon resonance

A nanolayered structure for sensitive detection of hemoglobin concentration using surface plasmon resonance

Design analysis of Bloch surface wave based sensor for haemoglobin concentration measurement

Sensitivity enhancement with anti-reflection coating of silicon nitride (Si3N4) layer in silver-based Surface Plasmon Resonance (SPR) sensor for sensing of DNA hybridization

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