Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors

Liu, Xiaowen; Tao, Huiquan; Yang, Kai; Zhang, Shuai; Lee, Shuit‐Tong; Liu, Zhuang

doi:10.1016/j.biomaterials.2010.08.096

Cited by 402 publications

(281 citation statements)

References 36 publications

(54 reference statements)

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“…They exhibited a thermal ablation threshold at a maximum tumor temperature of ~55°C, and a reduction in cancer cell growth was observed. 80 In the same research, Liu et al 81 systematically studied the dependency between the length and density of PEGylation on the SWCNT surface and the biodistribution, tumor accumulation, and photothermal ablation ability of PEG-functionalized SWCNTs syringed intravenously into mice. Results showed long blood circulation half-lives for heavily PEGylated SWCNTs and high tumor uptake.…”

Section: Cntsmentioning

confidence: 99%

“…This research proposed that the surface properties of CNTs are important to increase their unknown tumor-targeting abilities. 81 Beside these applications, functional groups with oxygen on oxidized SWCNTs have been applied to link FA molecules with the SWNTs and solubility of the FAfunctionalized SWNTs can be easily increased in water and phosphate-buffered saline after a long time. These FA-functionalized SWNTs have great potential for applications as biocompatible SWNTs.…”

Section: Cntsmentioning

confidence: 99%

See 1 more Smart Citation

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian

Lemraski

Webster

et al. 2017

IJN

439

216

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This review discusses the impact of green and environmentally safe chemistry on the field of nanotechnology-driven drug delivery in a new field termed “green nanomedicine”. Studies have shown that among many examples of green nanotechnology-driven drug delivery systems, those receiving the greatest amount of attention include nanometal particles, polymers, and biological materials. Furthermore, green nanodrug delivery systems based on environmentally safe chemical reactions or using natural biomaterials (such as plant extracts and microorganisms) are now producing innovative materials revolutionizing the field. In this review, the use of green chemistry design, synthesis, and application principles and eco-friendly synthesis techniques with low side effects are discussed. The review ends with a description of key future efforts that must ensue for this field to continue to grow.

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Section: Cntsmentioning

confidence: 99%

Section: Cntsmentioning

confidence: 99%

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Jahangirian

Lemraski

Webster

et al. 2017

IJN

439

216

View full text Add to dashboard Cite

show abstract

“…Studies have suggested that CNTs themselves are capable of being absorbed. It has also been established that physically shortened CNTs that are orally administered can be absorbed through the columnar cells of intestinal mucous membrane, where this was confirmed by transmission electron microscopy (Liu et al, 2011).…”

Section: Kinetics Of Cntsmentioning

confidence: 84%

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Kushwaha¹,

Ghoshal²,

Kumar³

et al. 2013

Braz. J. Pharm. Sci.

113

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Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.Uniterms: Carbon nanotubes/properties. Carbon nanotubes/use/drugs delivery. Single-Walled Carbon Nanotube. Multiwalled Carbon Nanotube. Anticancer drugs/delivery. Cancer/therapy. Drugs/delivery.Os nanotubos de carbono foram descobertos em 1991 e suas propriedades físico-químicas únicas demonstradas, despertando interesse em sua aplicação em vários campos, incluindo a entrega liberação de fármacos. As propriedades únicas dos nanotubos de carbono, tais como a facilidade de captação pela célula, carga alta de fármaco, ablação térmica, entre outras, tornaram-nos úteis para terapia de câncer, uma das doenças mais difíceis dos tempos modernos, pois sua terapia envolve a distinção entre as células normais saudáveis e as afetadas pela doença. Os nanotubos de carbono têm um papel importante nessa área porque fenômenos como EPR permitem que estes possam distinguir as células normais das afetadas, que é o Santo Graal na terapia do câncer. Trabalho considerável tem sido feito ao longo das duas últimas década com nanotubos de carbono, como sistemas de liberação de fármacos. No entanto, preocupações sobre algumas questões, como biocompatibilidade e toxicidade, surgiram ao longo do tempo, demandando extensas pesquisa nesse campo. Unitermos: Nanotubos de carbono/propriedades. Nanotubos de carbono/uso/liberação de fármacos. Nanotubo de carbono de parede única. Nanotubo de parede múltipla. Fármacos anticancer/liberação. Cancer/tratamento. Fármacos/liberação.

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“…While some studies have focused on the interaction of these hybrid CNTs with cells such as macrophages, lung epithelia, skin fibroblasts, and varied tumor cells at the cellular level, others have looked at their pharmacokinetics and biodistribution profiles in vivo. 62,70,[138][139][140][141][142][143][144][145][146] However, a majority of these strategies are focused at aiding the internalization of CNTs into their respective cell types for imaging and therapy. While this addresses the targeting component of the CNT-based nanoagents, it avoids the issue of opsonization when the particles are introduced into biofluids.…”

Section: Strategies To Shield Cntsmentioning

confidence: 99%

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Kotagiri¹,

Kim²

2014

IJN

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Carbon nanotubes (CNTs) have recently been in the limelight for their potential role in disease diagnostics and therapeutics, as well as in tissue engineering. Before these medical applications can be realized, there is a need to address issues like opsonization, phagocytosis by macrophages, and sequestration to the liver and spleen for eventual elimination from the body; along with equally important issues such as aqueous solubility, dispersion, biocompatibility, and biofunctionalization. CNTs have not been shown to be able to evade such biological obstacles, which include their nonspecific attachments to cells and other biological components in the bloodstream, before reaching target tissues and cells in vivo. This will eventually determine their longevity in circulation and clearance rate from the body. This review article discusses the current status, challenges, practical strategies, and implementations of coating CNTs with biocompatible and opsonin-resistant moieties, rendering CNTs transparent to opsonins and deceiving the innate immune response to make believe that the CNTs are not foreign. A holistic approach to the development of such “stealth” CNTs is presented, which encompasses not only several biophysicochemical factors that are not limited to surface treatment of CNTs, but also extraneous biological factors such as the protein corona formation that inevitably controls the in vivo fate of the particles. This review also discusses the present and potential applications, along with the future directions, of CNTs and their hybrid-based nanotheranostic agents for multiplex, multimodal molecular imaging and therapy, as well as in other applications, such as drug delivery and tissue engineering.

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Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors

Cited by 402 publications

References 36 publications

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine

Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

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