Optimization of supercritical fluid extraction of lycopene from tomato skin with central composite rotatable design model

Kassama, Lamin S.; Shi, John; Mittal, G.S.

doi:10.1016/j.seppur.2007.09.005

Cited by 106 publications

(57 citation statements)

References 20 publications

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“…On the other hand, some studies attribute to the cis isomer a higher bioavailability (Schieber & Carle, 2005). However, a lower temperature of 60°C gives the highest yields for trans-lycopene (Kassama, Shi, & Mittal, 2008;Nobre, Palavra, Pessoa, & Mendes, 2009) which the authors postulate is due to promotion of isomerisation into the cis form at temperatures above 80°C (Wang & Chen, 2006). Temperatures below 70°C seem to favour the extraction of β-carotene with most authors reporting that temperatures between 55 and 59°C are optimal (Sanal, Güvenç, Salgin, Mehmetoglu, & Çalimli, 2004;Vega et al, 1996).…”

Section: Carotenoidsmentioning

confidence: 99%

Techniques to extract bioactive compounds from food by-products of plant origin

Wijngaard

Hossain

Dilip

et al. 2012

Food Research International

266

150

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Section: Carotenoidsmentioning

confidence: 99%

Techniques to extract bioactive compounds from food by-products of plant origin

Wijngaard

Hossain

Dilip

et al. 2012

Food Research International

266

150

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“…5. Oil yield increased with temperature as increments in temperature enhanced the mass transfer rate [28,45,46].…”

Section: Optimization Of Scf Extractionsmentioning

confidence: 99%

Response surface method applied to supercritical carbon dioxide extraction of Vetiveria zizanioides essential oil

Danh

Mammucari

Truong³

et al. 2009

Chemical Engineering Journal

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“…Further, the effects of drug/lipid ratio (X 1 ), organic/ aqueous phase ratio (X 2 ) and surfactant concentration (X 3 ) on the entrapment efficiency (EE), drug loading (DL) percentage and mean particle size (PS) of IF NLC were investigated in detail making use of central composite rotatable design (CCRD) which is an ideal tool for process optimization (Box and Hunter 1957;Kassama et al 2008). Model equations were derived by computer simulation programming Design Expert Ò 8.0.7.1 to optimize Ifosfamide NLC.…”

Section: Introductionmentioning

confidence: 99%

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Velmurugan

Selvamuthukumar

2015

Appl Nanosci

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The research focuses on the development and optimization of ifosfamide nanostructured lipid carriers for oral delivery with the application of response surface methodology. The objectives of the study were to develop a formulation for ifosfamide to be delivered orally, overcome the instability of the drug in acidic environment during oral administration, to sustain the release, drug leakage during storage and low loading capacity. A modified solvent diffusion method in aqueous system was applied to prepare nanostructured lipid nanoparticles. Hydrophilic polymers such as chitosan and sodium alginate were used as coating materials. Glycerol mono oleate and oleic acid were used as solid and liquid lipid, respectively. Poloxamer is used as stabilizers. The central composite rotatable design consisting of three-factored factorial design with three levels was used in this study. The physiochemical characterization included evaluation of surface morphology, particle size and surface charge of the drug in the delivery system. The in vitro drug release, entrapment and drug loading efficiency and as well as the storage stability were evaluated. The results showed that the optimal formulation was composed of drug/lipid ratio of 1:3, organic/aqueous phase ratio of 1:10 and concentration of surfactant of 1 % w/v. Ifosfamide nanostructured lipid carrier under the optimized conditions gave rise to the entrapment efficiency of 77 %, drug loading of 6.14 %, mean diameter of 223 nm and zeta potential value of -25 mV. Transmission electron microscopy analysis showed spherical particles. The in vitro experiment proved that ifosfamide from the delivery system released gradually over the period of 72 h. Sodium alginate cross-linked chitosan nanostructured lipid carrier demonstrated enhanced stability of ifosfamide, high entrapment efficiency and sustained release.

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Optimization of supercritical fluid extraction of lycopene from tomato skin with central composite rotatable design model

Cited by 106 publications

References 20 publications

Techniques to extract bioactive compounds from food by-products of plant origin

Techniques to extract bioactive compounds from food by-products of plant origin

Response surface method applied to supercritical carbon dioxide extraction of Vetiveria zizanioides essential oil

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

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