Optimization of Supercritical CO<sub>2</sub> Extraction of Essential Oil from <i>Artemisia annua</i> L. by Means of Response Surface Methodology

Li, Yinta; Xia, Ling; Vazquez, Jorge Fernando Toro; Song, Shaoxian

doi:10.1080/0972060x.2017.1298475

Cited by 16 publications

(11 citation statements)

References 19 publications

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“…According to Quispe-Condori et al (2005), maximum artemisinin global yield is achieved at 300 bar and 50°C temperature. Li et al (2017) showed that the extraction time and pressure had the highest positive effect on oil extraction, while the effects of CO 2 flow rate and temperature were less important. The extraction yield of 11.17 % was achieved at 250 bar, 50°C, 25 g/min, and 2 h extraction time (Li et al, 2017).…”

Section: Influence Of Process Parameters Of Sc-co 2 On Extraction Yieldmentioning

confidence: 98%

“…Li et al (2017) showed that the extraction time and pressure had the highest positive effect on oil extraction, while the effects of CO 2 flow rate and temperature were less important. The extraction yield of 11.17 % was achieved at 250 bar, 50°C, 25 g/min, and 2 h extraction time (Li et al, 2017). However, the range of investigated CO 2 flow was 10-30 g/min, which is a significantly higher CO 2 flow than the one applied in this study.…”

Section: Influence Of Process Parameters Of Sc-co 2 On Extraction Yieldmentioning

confidence: 98%

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Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide

Vidović¹,

Simić²,

Gavarić³

et al. 2020

Lekovite sirovine

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In this study, supercritical carbon dioxide was applied for the extraction of Artemisia annua L. Moreover, the impact of different parameters of supercritical extraction on total yield was investigated and the obtained yields were compared to the ones obtained by conventional procedures, hydrodistillation and Soxhlet extraction. Supercritical fluid extraction at 40 °C and different pressures (100, 200, and 300 bar) resulted in extraction yields that were in the 2.23-5.18 % range, while the yields at 60 °C and the same pressures were in the range 2.43-3.35 %. The yields obtained by the Soxhlet extraction and hydrodistillation were 10.28 % and 0.10 %, respectively. Although supercritical fluid extraction is inferior to Soxhlet extraction in terms of the recovery of lipophilic components of A. annua, the Soxhlet extraction is not the method of choice for obtaining sweet wormwood extracts due to its numerous disadvantages that include the use of toxic solvents, extended extraction time, health safety of the product, the need for further processing, the impossibility of adjusting the selectivity and thus the composition of the product.

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Section: Influence Of Process Parameters Of Sc-co 2 On Extraction Yieldmentioning

confidence: 98%

Section: Influence Of Process Parameters Of Sc-co 2 On Extraction Yieldmentioning

confidence: 98%

Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide

Vidović¹,

Simić²,

Gavarić³

et al. 2020

Lekovite sirovine

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“…Supercritical CO 2 extraction is also commonly used in the extraction of oils and fats, which has the advantages of low cost, nontoxicity, and environmental friendliness. The density, viscosity, and diffusion coefficient of CO 2 can be controlled by adjusting the temperature and pressure of SCO 2 , achieving the aim of improving the extraction rate or selectivity of oil and fat (Cvjetko et al, 2012;Jokić, Bijuk, Aladić, Bilić, & Maja, 2016;Li, Xia, Vazquez, & Song, 2017). However, the pressure of supercritical extraction is high and the equipment is expensive (Sahena et al, 2009), which have kept the technology from being widely used in industries.…”

Section: Introductionmentioning

confidence: 99%

Extraction of rapeseed cake oil using subcritical R134a/butane: Process optimization and quality evaluation

Guo

Wan

Huang

2019

Food Science & Nutrition

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The optimal extraction conditions of rapeseed cake oil using subcritical R134a/butane were established by response surface methodology. The quality of subcritical R134a/butane extraction oil (SRBEO) was compared with supercritical CO2 extraction oil (SCO2EO) and hexane extraction oil (HXEO). The results showed the highest extraction yield obtained by subcritical R134a/butane in the condition of R134a‐butane ratio of 1.5 kg/kg, at 45°C for 50 min. Compared with SCO2EO and HXEO, the extraction yield and β‐carotene content of SRBEO (87.76%, 357.21 μg/100g) were the highest. The content of phospholipids and canolol in SRBEO (3.01 mg/g, 118.51 mg/100 g) was higher than SCO2EO (not detected, 95.82 mg/100 g) and less than HXEO (25.78 mg/g, 131.85 mg/100 g). The tocopherols in SRBEO were equivalent to SCO2EO but phytosterol content of SRBEO (560.19 mg/100 g) was less than SCO2EO (591.40 mg/100 g). For fatty acids, the three extraction oils had slight difference. Thus, subcritical R134a/butane extraction appeared to be feasible for rapeseed cake oil extraction.

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“…Since artemisinin is soluble in SC‐CO 2 at selected conditions, some attempts have been made at its direct extraction from dried and ground leaves of Artemisia annua L . For instance, Martinez‐Correa et al .…”

Section: Introductionmentioning

confidence: 99%

“…Since artemisinin is soluble in SC-CO 2 at selected conditions, 15 some attempts have been made at its direct extraction from dried and ground leaves of Artemisia annua L. [16][17][18] For instance, Martinez-Correa et al 19 performed SC-CO 2 extraction at 400 bar and 60 ∘ C. The extraction yield, quantified in terms of artemisinin, was similar to ethanol extraction and volatile compounds were collected using a cartridge. However, it is well known that the process conditions adopted in that work cannot be used for selective extraction owing to the very large solvent power expressed by SC-CO 2 at high pressures.…”

Section: Introductionmentioning

confidence: 99%

Artemisia annua organic solvent extract, processed by supercritical CO₂

Baldino

Reverchon

2018

J of Chemical Tech & Biotech

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BACKGROUND Artemisia annua L. extraction is traditionally performed using hexane; the process is simple, but not selective. In this work, a strategy to concentrate artemisinin and the other similar active principles in the final extract is proposed, combining cheapness of maceration and selectivity of SC‐CO2 processing. RESULTS Hexane extraction produced a solid, waxy extract with a yield of 3.3% w/w with respect to the starting vegetable material. Then, SC‐CO2 processing of this solid extract was performed operating at 0.8 kg h−1 SC‐CO2 flow rate and at different operative parameters. Very selective conditions were found operating at 90 bar and 50°C, obtaining a final product containing more than 71% w/w of active compounds (artemisinin, artemisin and dehydroartemisinin). CONCLUSION Using this approach, a product more than 2.6 times richer in artemisinin than the one obtained by conventional techniques and about 2 times richer than direct CO2 extraction, was obtained. Another relevant result is that the overall process scheme is cheaper than direct CO2 extraction, since a high pressure extractor about 20 times smaller can be used, to process the waxy product obtained by hexane extraction. © 2018 Society of Chemical Industry

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Optimization of Supercritical CO₂ Extraction of Essential Oil from Artemisia annua L. by Means of Response Surface Methodology

Cited by 16 publications

References 19 publications

Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide

Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide

Extraction of rapeseed cake oil using subcritical R134a/butane: Process optimization and quality evaluation

Artemisia annua organic solvent extract, processed by supercritical CO₂

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Optimization of Supercritical CO2 Extraction of Essential Oil from Artemisia annua L. by Means of Response Surface Methodology

Cited by 16 publications

References 19 publications

Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide

Extraction of sweet wormwood (Artemisia annua L.) by supercritical carbon dioxide

Extraction of rapeseed cake oil using subcritical R134a/butane: Process optimization and quality evaluation

Artemisia annua organic solvent extract, processed by supercritical CO2

Contact Info

Product

Resources

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Optimization of Supercritical CO₂ Extraction of Essential Oil from Artemisia annua L. by Means of Response Surface Methodology

Artemisia annua organic solvent extract, processed by supercritical CO₂