In a previous study, we reported that aqueous extract of the wild mushroom (Ganoderma sp) contained bioactive phytochemicals and has efficacy against caecal coccidiosis in broilers. In the current study, the efficacy of organic solvent extracts from the wild Ganoderma (butanol, methanol and ethyl acetate) against Eimeria tenella were evaluated in 6 weeks broiler chickens infected with 10,000 sporulated oocysts of E. tenella/ml/bird via the crop using insulin syringe. The birds were reared in separate wire cages (4 birds/group in duplicate) labelled A = representing broilers not infected with E. tenella (negative control), B = broilers infected but not treated (positive control), C = broilers infected and treated with aqueous Ganoderma, D = broilers infected and treated with methanol extract of Ganoderma, E = broilers infected and treated with ethyl acetate extract of Ganoderma, F = broilers infected and treated with butanol extract of Ganoderma, G = broilers infected and treated with anticoccidia (amprolium) as positive control for comparison. All the treatments were administered (2 ml/bird) for 6 days in the morning and evening. Feed intake, body weight, faecal oocysts and haematological parameters were evaluated. The results showed that all the infected broilers in group B, C, D, E, F and G became dull and weak on day 5 post-infection. Broilers that were not infected remained apparently active and healthy (group A). By the 10th day post-infection the faecal droppings of infected broilers were bloody and watery. Group B, F and G had morbidity and mortality of 2.5% respectively. Prior to treatment the oocysts detected were 6000 and 8000 in group D and G respectively, followed by E and F (4000 each), H (4200), B (3500) and C (3350). There were no oocysts detected after the treatment except in broilers that were infected but not treated (group B), which had oocysts in their faecal dropping and intestinal scrapping. Broilers in group G had higher feed intake, followed by group F, D and E. They also had higher body weight gain. Group B had low packed cell volume (28.4 %) possibly due to haemorrhage caused by the coccidial infection. Feed intake, body weight gain and haematological responses were significantly different (P<0.05). This study confirmed the need to exploit this macrofungus as a potential anticoccidial agent for control of coccidiosis in poultry.