Optimization of startup and shutdown operation of simulated moving bed chromatographic processes

Prediction‐correction method for optimization of simulated moving bed chromatography

“…Another advantage of obtaining SMB model parameters by the PC algorithm is that we obtain the optimal CSS operating conditions and more reliable parameters that can predict the transient SMB behavior during startup or shutdown. In the near future, we will verify optimal startup and shutdown strategies for SMB as discussed in Li et al 18 for both linear and Langmuir isotherm systems. Finally, it should be noted that more advanced NLP solvers may improve the computational efficiency.…”

“…96%, and with F max ¼ 10 mL min À1 . The objective function convergence tolerance, e tol in (18) was set to 0.05. The optimal operating conditions, u k are predicted to satisfy the purity constraints at maximum throughput.…”

“…These conditions were implemented in the kth SMB experiment until the PC algorithm termination criteria were met. The optimal operating conditions are shown in Table 2 along with the experimental product purities obtained in the kth experiment and the normalized change in throughput from (18). In all optimal solutions the Zone 1 flow rate F 1 reached the upper bound of 10 mL min À1 so that larger concentrations of components can be sufficiently desorbed when the feed flow rate is maximized.…”

“…The SMB experimental data for k ¼ 0-2 are displayed together in Figure 5. The termination criteria were satisfied at k ¼ 2 because the product purities in SMB experiment 3 were both over 96% and (18) was satisfied. Because the termination criteria were satisfied at k ¼ 2, the optimal operating conditions u 3 were not used, and u à 2 was considered optimal.…”

Development of the method for determining optimal parameters of the process of displacement of technological objects

“…Different criteria of management quality are typically applied when optimizing the process of displacement under dynamic and established mode [6]. At the same time, the goal of functioning of any technological process is to maximize financial capacities of the super-system.…”