Optimization of small molecule degraders and antagonists for targeting estrogen receptor based on breast cancer: current status and future
Jiaqi Yao,
Yiran Tao,
Zelin Hu
et al.
Abstract:The estrogen receptor (ER) is a classical receptor protein that plays a crucial role in mediating multiple signaling pathways in various target organs. It has been shown that ER-targeting therapies inhibit breast cancer cell proliferation, enhance neuronal protection, and promote osteoclast formation. Several drugs have been designed to specifically target ER in ER-positive (ER+) breast cancer, including selective estrogen receptor modulators (SERM) such as Tamoxifen. However, the emergence of drug resistance … Show more
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