Optimization of silver nanoparticles biosynthesis mediated by Aspergillus niger NRC1731 through application of statistical methods: enhancement and characterization

Elsayed, Maysa A.; Othman, Abdelmageed M.; Hassan, Mohamed M.; Elshafei, Ali M.

doi:10.1007/s13205-018-1158-6

Cited by 18 publications

(12 citation statements)

References 25 publications

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“…The size and high surface area of AgNPs play an important role by enabling them to reach easily the nuclear content of bacteria to exhibit relatively high antibacterial activity (Yurtluk et al, 2018). Similar reports have been documented by Elsayed et al (2018) and Sowmya et al (2019) suggested that + AgNPs exhibit antibacterial activity by releasing Ag ions, which gets attached to the surface of bacterial cell membrane and may disrupt membrane permeability, DNA replication, induce ROS and subsequently leading to bacterial cell death.…”

Section: X-raysupporting

confidence: 52%

Biogenic synthesis of silver nanoparticles using Paenibacillus sp. in-vitro and their antibacterial, anticancer activity assessment against human colon tumour cell line

Sreenivasa¹,

Meghashyama²,

Sharma³

et al. 2021

JEB

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Aim: To evaluate the antibacterial and anticancer activities of silver nanoparticles (AgNPs) synthesized from aqueous extract of Paenibacillus sp. strain NS-36. Methodology: The green synthesized AgNPs were characterized by UV-Vis. spectroscopy, Fourier Transform Infrared Spectroscopy, Atomic Force Microscopy, X-Ray Diffraction, Scanning Electron Microscopy, Energy Dispersive X-ray Spectroscopy, and Transmission Electron Microscopy. Antibacterial activity was assessed against pathogenic bacteria by using agar well diffusion method and the anticancer activity was evaluated against Human Colon Tumour-116 cell line using 96 well plate cell proliferation assay. Results: The synthesized AgNPs showed UV-Vis absorbance peak at 416 nm. The characterization analyses revealed the shape as spherical and size ranging from 17.49 to 52.85 nm and the presence of different functional groups and elements that involved in the stabilization and capping. The antibacterial activity revealed that AgNPs have good inhibitory action on pathogens, whereas the results of anticancerous assessment indicated that AgNPs have a dose-dependent activity on the Human Colon Tumour-116 cancer cells and the IC50 value was found to be 81.45 μg ml-1. Interpretation: The AgNPs exhibited considerable antibacterial activity against bacterial pathogens by rupturing and damaging the cell membrane. The AgNPs release silver ions into the cell once they attached to the cell membrane and disrupt the bacterial DNA replication. The AgNPs are toxic to tumour cells and induce intracellular reactive oxygen species which damage cells. Along with ROS, the rounding and shrinkage of tumour cells caused by AgNPs reduced the % viability of cancer cells. Key words: Antimicrobial activity, Cytotoxicity, Paenibacillus sp, Silver nanoparticles, Tumour cells

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Section: X-raysupporting

confidence: 52%

Biogenic synthesis of silver nanoparticles using Paenibacillus sp. in-vitro and their antibacterial, anticancer activity assessment against human colon tumour cell line

Sreenivasa¹,

Meghashyama²,

Sharma³

et al. 2021

JEB

View full text Add to dashboard Cite

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“…Production of AgNPs follows the equations described above. The reaction of synthesis can be confirmed by change in the color of the medium [71]. Several aspects as medium properties, incubation time and temperature, AgNO 3 and biomass concentrations and activity, are of crucial relevance.…”

Section: Green Chemistrymentioning

confidence: 90%

“…Based on analysis, its assumed that these biomolecules and proteins may be involved in the capping stabilization. IR spectra vary with the characteristics of the organism/specie used in the AgNPs synthesis [71].…”

Section: Characterization Of Agnpsmentioning

confidence: 99%

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

et al. 2020

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Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to a specific receptor in the bacterial cell) which not only makes the development of resistance by bacteria difficult, but also broadens the spectrum of antibacterial activity. As a result, a large majority of metal-based nanoparticles efficacy studies performed so far have shown promising results in both Gram-positive and Gram-negative bacteria. The aim of this review has been a comprehensive discussion of the state of the art on the use of the most relevant types of metal nanoparticles employed as antimicrobial agents. A special emphasis to silver nanoparticles is given, while others (e.g., gold, zinc oxide, copper, and copper oxide nanoparticles) commonly used in antibiotherapy are also reviewed. The novelty of this review relies on the comparative discussion of the different types of metal nanoparticles, their production methods, physicochemical characterization, and pharmacokinetics together with the toxicological risk encountered with the use of different types of nanoparticles as antimicrobial agents. Their added-value in the development of alternative, more effective antibiotics against multi-resistant Gram-negative bacteria has been highlighted.

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“…The application of new approaches such as synthesis optimization via statistical methods (such as central composite design and response surface methodology) has been proposed in a few studies and showed some promise but remains mostly unexplored [ 98 , 101 ]. Such approaches are expected to significantly reduce the number of different lab tests required and lead to a quicker optimization of MNP production, thus warranting a closer look.…”

Section: Discussionmentioning

confidence: 99%

Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses

2020

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Mycobacterial infections are a resurgent and increasingly relevant problem. Within these, tuberculosis (TB) is particularly worrying as it is one of the top ten causes of death in the world and is the infectious disease that causes the highest number of deaths. A further concern is the on-going emergence of antimicrobial resistance, which seriously limits treatment. The COVID-19 pandemic has worsened current circumstances and future infections will be more incident. It is urgent to plan, draw solutions, and act to mitigate these issues, namely by exploring new approaches. The aims of this review are to showcase the extensive research and application of silver nanoparticles (AgNPs) and other metal nanoparticles (MNPs) as antimicrobial agents. We highlight the advantages of mycogenic synthesis, and report on their underexplored potential as agents in the fight against all mycobacterioses (non-tuberculous mycobacterial infections as well as TB). We propose further exploration of this field.

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Optimization of silver nanoparticles biosynthesis mediated by Aspergillus niger NRC1731 through application of statistical methods: enhancement and characterization

Cited by 18 publications

References 25 publications

Biogenic synthesis of silver nanoparticles using Paenibacillus sp. in-vitro and their antibacterial, anticancer activity assessment against human colon tumour cell line

Biogenic synthesis of silver nanoparticles using Paenibacillus sp. in-vitro and their antibacterial, anticancer activity assessment against human colon tumour cell line

Metal-Based Nanoparticles as Antimicrobial Agents: An Overview

Mycogenic Metal Nanoparticles for the Treatment of Mycobacterioses

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