Optimization of silver-containing bioglass nanoparticles envisaging biomedical applications

Abstract

Bioglass nanoparticles (BGs) are of outmost importance in the biomedical field, because their unique characteristics, namely osteoconductivity and osteoinductivity, and also in certain conditions, angiogenic and bactericidal properties. In this work, novel bioglass nanoparticles containing silver (AgBGs) were synthesized by a sol-gel method, adopting different thermal treatments to obtain new nanoparticles with bioactive and antibacterial features. This is the first systematic study of the effect of the thermal treatment on the properties of AgBGs. The effect of the studied thermal treatments on the properties of synthesized nanoparticles was analyzed by several characterization techniques: FT-IR, XRD, STEM , SEM-EDS and Zeta potential. FT-IR allowed the identification of the characteristic peaks of the nanoparticles and XRD revealed the presence of the characteristic peaks of an apatite-like phase. By STEM analysis it was found that the produced nanoparticles are dense and have a diameter < 200 nm. The SEM micrographs showed their surface morphology and Zeta potential measurements were performed to study their suspension stability. Additionally, in vitro bioactivity tests confirmed their bioactive potential and the microbiological tests evidenced their bactericidal effect. These promising AgBGs could be incorporated either in 2D or 3D structures for several biomedical applications, namely in the orthopedic and dental fields.

Antibacterial free-standing polysaccharide composite films inspired by the sea

“…S4-C, D) and a decrease of silicon (Si), due to the dissolution of Ag-BGs. Furthermore, as expected for F3 and F4, EDS showed Ca/P ratios which are closed to the stoichiometric composition of hydroxyapatite (1.67) [46,90]: 1.5 for both formulations with AgBGs, confirming their bioactivity potential of these LbL constructions, similarly with previous results obtained only for these AgBGs [46].…”

“…In the present work, new multifunctional free-standing (FS) films were proposed for guided bone regeneration, consisting in the incorporation of a quaternary formulation [SiO 2 -CaO-P 2 O 5 -Ag 2 O = 56:30:4:10%mol] of silver doped bioglass nanoparticles, AgBGs, in the build-up of antibacterial and adhesive naturally-based FS films. These Ag-BGs were previously optimized and characterized by our group [46,47], revealing bioactive and antimicrobial properties that could be interesting to prevent recurrent post-surgical infections. On one hand, it has been established that nanoparticles composed by SiO 2 , CaO and P 2 O 5 induced an apatite-like layer formation [48][49][50].…”

Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

“…This type of inorganic material is widely employed in orthopedic and dental settings [1]. Various elements have been added to bioactive ceramics to enhance their bioactivity, such as silver (Ag) for antibacterial effects [2], strontium (Sr) for bone growth [3], and magnesium (Mg) for bone mineralization [3]. Boron (B) can influence bone growth and can act as a nutrition component to enhance bone strength under compression [4].…”

Electrospun polycaprolactone membranes with Zn-doped bioglass for nasal tissues treatment

“…Another material which was successfully used in nasal reconstruction surgery, showing good results in the reconstruction of perforation of the nasal septum, was bioglass (BG) [ 11 ]. BG is a type of bioactive ceramic material generally composed by SiO 2 –CaO–P 2 O 5 and Na 2 O and it can mainly be synthesized through two approaches: melting or sol–gel [ 12 ]. The major advantage of BG is its excellent bioactivity.…”