Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects

Xia, Yiming; Hill, Kristina E.; Li, Ping; Xu, Jiayuan; Zhou, Dingyou; Motley, Amy K.; Wang, Li; Byrne, Daniel W.; Burk, Raymond F.

doi:10.3945/ajcn.2010.29642

Cited by 200 publications

(187 citation statements)

References 30 publications

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“…of selenoprotein P (SEPP1) (19), the level of which has been positively associated with type II diabetes risk in humans (20). That this relationship may be causal is suggested by findings that insulin signaling in the mouse was impaired by administration of purified SEPP1 but enhanced by genetic deletion or RNA interference-mediated SEPP1 knockdown (20).…”

mentioning

confidence: 87%

S-Adenosylmethionine-dependent Protein Methylation Is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in HepG2 Human Hepatocytes

Jackson

Cao

Zeng

et al. 2012

Journal of Biological Chemistry

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Background: Protein methylation is required for gluconeogenic enzyme expression. Selenoprotein P is transcriptionally controlled similarly to gluconeogenenic enzymes. S-adenosylhomocysteine is an inhibitor of methylation. Results: S-Adenosylhomocysteine decreases selenoprotein P and gluconeogenic enzyme expression. Conclusion: Hepatocellular methylation is a nexus of control over selenoprotein P and gluconeogenic enzyme expression. Significance: Determination of how methylation affects proteins involved in type II diabetes may aid in development of therapeutics.

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mentioning

confidence: 87%

S-Adenosylmethionine-dependent Protein Methylation Is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in HepG2 Human Hepatocytes

Jackson

Cao

Zeng

et al. 2012

Journal of Biological Chemistry

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“…Plasma SEPP1 also has potential as a selenium biomarker. Studies that repleted selenium-deficient humans in China found that the selenium requirement based on plasma SEPP1 was 50% higher than the requirement based on plasma GPX3 activity (40). Liver is the major source of plasma SEPP1 in rodents and humans (41,42).…”

Section: Discussionmentioning

confidence: 99%

Insights for Setting of Nutrient Requirements, Gleaned by Comparison of Selenium Status Biomarkers in Turkeys and Chickens versus Rats, Mice, and Lambs

Sunde

Taylor

2016

Advances in Nutrition

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To gain insights into nutrient biomarkers and setting of dietary nutrient requirements, selenium biomarker levels and requirements in response to multiple graded levels of dietary selenium were compared between day-old turkeys and chickens versus weanling rats and mice and 2-d-old lambs supplemented with sodium selenite. In rodents, there was no significant effect of dietary selenium on growth, indicating that the minimum selenium requirement was <0.007 mg Se/g diet. In contrast, there was a significant effect in turkeys, chicks, and lambs, which showed selenium requirements for growth of 0.05, 0.025, and 0.05 mg Se/g diet, respectively. Liver glutathione peroxidase (GPX) 1 activity fell in all species to <4% of selenium-adequate levels, plasma GPX3 activity fell to <3% in all species except for mice, and liver GPX4 activity fell to <10% in avians but only to ;50% of selenium-adequate levels in rodents. Selenium-response curves for these biomarkers reached well-defined plateaus with increasing selenium supplementation in all species, collectively indicating minimum selenium requirements of 0.06-0.10 mg Se/g for rats, mice, and lambs but 0.10-0.13 mg Se/g for chicks and 0.23-0.33 mg Se/g for turkeys. In contrast, increasing dietary selenium did not result in well-defined plateaus for erythrocyte GPX1 activity and liver selenium in most species. Selenium-response curves for GPX1 mRNA for rodents and avians had well-defined plateaus and similar breakpoints. GPX4 mRNA was not significantly regulated by dietary selenium in rodents, but GPX4 mRNA in avians decreased in selenium deficiency to ;35% of selenium-adequate plateau levels. Notably, no selenoprotein activities or mRNA were effective biomarkers for supernutritional selenium status. Robust biomarkers, such as liver GPX1 and plasma GPX3 activity for selenium, should be specific for the nutrient, fall dramatically in deficiency, and reach well-defined plateaus. Differences in biomarker-response curves may help researchers better understand nutrient metabolism and targeting of tissues in deficiency, thus to better characterize requirements. Adv Nutr 2016;7:1129-38.

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“…The recommended intake in order to obtain optimal plasma activity of the main enzymes glutathione peroxidase and selenoprotein P differs. Xia et al presented data indicating that for a normal weighted (about 76kg) Caucasian a selenium intake of 75 μg/day would be necessary in order to optimize the function of selenoprotein P [37]. Hurst et al demonstrated a total selenium intake of 105 μg/day to achieve optimal function of selenoprotein P, while a relative selenium deficiency might exist in the most of the European countries [38].…”

Section: Selenium and Cardiovascular Diseases: From Prevention To Carmentioning

confidence: 99%

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen

Aaseth

2015

Journal of Trace Elements in Medicine and Biology

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Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects

Cited by 200 publications

References 30 publications

S-Adenosylmethionine-dependent Protein Methylation Is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in HepG2 Human Hepatocytes

S-Adenosylmethionine-dependent Protein Methylation Is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in HepG2 Human Hepatocytes

Insights for Setting of Nutrient Requirements, Gleaned by Comparison of Selenium Status Biomarkers in Turkeys and Chickens versus Rats, Mice, and Lambs

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

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