Optimization of RNAi efficiency in PVD neuron ofC. elegans
Pallavi Singh,
Kavinila Selvarasu,
Anindya Ghosh-Roy
Abstract:PVD neuron ofC. eleganshas become an attractive model for the study of dendrite development and regeneration due to the elaborate and stereotype dendrite morphology in this neuron. The molecular basis for dendrite maintenance and regeneration is poorly understood. RNA interference (RNAi) by feedingE. coliexpressing dsRNA has been the basis of several genome wide screens performed usingC. elegans. However, the feeding method often fails when it comes to nervous system. Using an optimal induction condition for t… Show more
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