Optimization of q-space sampling for mean apparent propagator MRI metrics using a genetic algorithm

Olson, Daniel V.; Arpinar, Volkan Emre; Muftuler, L. Tugan

doi:10.1016/j.neuroimage.2019.05.078

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…A recently developed diffusion model, called mean apparent propagator (MAP) MRI, can overcome this limitation. The MAP MRI model does not make any prior assumptions about the behavior of the water diffusion in the tissues (Hosseinbor et al, 2013;Olson et al, 2019). This method models broader q-space signals utilizing Hermite polynomials (Özarslan et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…This method models broader q-space signals utilizing Hermite polynomials (Özarslan et al, 2013). As a result, more subtle changes in complex microstructures could be investigated by the MAP MRI metrics than the DTI (Özarslan et al, 2013;Olson et al, 2019). For MAP MRI, the mean square displacement (MSD) can be derived from the diffusion propagator models to measure the average amount of diffusion, and zero displacement probabilities, including the return to the origin probability (RTOP), the return to the axis probability (RTAP) and the return to the plane probability (RTPP), can be derived to quantify various features of the three-dimensional diffusion process (Hosseinbor et al, 2013;Özarslan et al, 2013;Ning et al, 2015;Fick et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study

Zeng

Zhang

et al. 2020

Front. Aging Neurosci.

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Background and Purpose: Mean apparent propagator (MAP) MRI is a novel diffusion imaging method to map tissue microstructure. The purpose of this study was to evaluate the diagnostic value of the MAP MRI in Parkinson's disease (PD) in comparison with conventional diffusion tensor imaging (DTI). Methods: 23 PD patients and 22 age-and gender-matched healthy controls were included. MAP MRI and DTI were performed on a 3T MR scanner with a 20-channel head coil. The MAP metrics including mean square displacement (MSD), return to the origin probability (RTOP), return to the axis probability (RTAP), and return to the plane probability (RTPP), and DTI metrics including fractional anisotropy (FA), and mean diffusivity (MD), were measured in subcortical gray matter and compared between the two groups. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic performance of all the metrics. The association between the diffusion metrics and disease severity was assessed by Pearson correlation analysis. Results: For MAP MRI, the mean values of MSD in the bilateral caudate, pallidum, putamen, thalamus and substantia nigra (SN) were higher in PD patients than in healthy controls (p FDR ≤ 0.001); the mean values of the zero displacement probabilities (RTOP, RTAP, and RTPP) in the bilateral caudate, pallidum, putamen and thalamus were lower in PD patients (p FDR < 0.001). For DTI, only FA in the bilateral SN was significantly higher in PD patients than those in the controls (p FDR < 0.001). ROC analysis showed that the areas under the curves of MAP MRI metrics (MSD, RTOP, RTAP, and RTPP) in the bilateral caudate, pallidum, putamen and thalamus (range, 0.85-0.94) were greater than those of FA and MD of DTI (range, 0.55-0.69) in discriminating between PD patients and September 2020 | Volume 12 | Article 563595 Le et al. MAP MRI in PD healthy controls. RTAP in the ipsilateral pallidum (r = −0.56, p FDR = 0.027), RTOP in the bilateral and contralateral putamen (r = −0.58, p FDR = 0.019; r = −0.57, p FDR = 0.024) were negatively correlated with UPDRS III motor scores. Conclusion: MAP MRI outperformed the conventional DTI in the diagnosis of PD and evaluation of the disease severity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study

Zeng

Zhang

et al. 2020

Front. Aging Neurosci.

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“…MAP-MRI may have great potential in evaluating brain glioma-induced structural damage to the CST; however, an intensive acquisition of MAP-MRI impedes its extensive clinical application (21). In several cases, an accurate estimation of these features takes a long acquisition time due to the large b-values and directions.…”

Section: Discussionmentioning

confidence: 99%

Laplacian-Regularized Mean Apparent Propagator-MRI in Evaluating Corticospinal Tract Injury in Patients with Brain Glioma

Jiang

Song

et al. 2021

Korean J Radiol

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Objective: To evaluate the application of laplacian-regularized mean apparent propagator (MAPL)-MRI to brain glioma-induced corticospinal tract (CST) injury. Materials and Methods: This study included 20 patients with glioma adjacent to the CST pathway who had undergone structural and diffusion MRI. The entire CSTs of the affected and healthy sides were reconstructed, and the peritumoral CSTs were manually segmented. The morphological characteristics of the CST (track number, average length, volume, displacement of the affected CST) were examined and the diffusion parameter values, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), radial diffusivity (RD), mean squared displacement (MSD), q-space inverse variance (QIV), returnto-origin probability (RTOP), return-to-axis probabilities (RTAP), and return-to-plane probabilities (RTPP) along the entire and peritumoral CSTs, were calculated. The entire and peritumoral CST characteristics of the affected and healthy sides as well as those relative CST characteristics of the patients with motor weakness and normal motor function were compared. Results: The track number, volume, MD, RD, MSD, QIV, RTAP, RTOP, and RTPP of the entire and peritumoral CSTs changed significantly for the affected side, whereas the AD and FA changed significantly only in the peritumoral CST (p < 0.05). In patients with motor weakness, the relative MSD of the entire CST, QIV of the entire and peritumoral CSTs, and the AD, MD, RD of the peritumoral CST were significantly higher, whereas the RTPP of the entire and peritumoral CSTs and the RTOP of the peritumoral CST were significantly lower than those in patients with normal motor function (p < 0.05 for all). In contrast, no significant changes were found in the CST morphological characteristics, FA, or RTAP (p > 0.05 for all). Conclusion: MAPL-MRI is an effective approach for evaluating microstructural changes after CST injury. Its sensitivity may improve when using the peritumoral CST features.

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“…Mean apparent propagator (MAP)-MRI, a newly developed diffusion model, has the potential to circumvent this limitation. The MAP-MRI model makes no prior presuppositions regarding the behavior of water diffusion in tissues ( Hosseinbor et al, 2013 ; Olson et al, 2019 ). Instead, it is based on q-space sampling ( Özarslan et al, 2013 ) and measures the probability density function of spin displacements in complex microstructures of brain tissue to examine the dispersion distribution of water molecules ( Avram et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease

Qiu

et al. 2022

Front. Neurosci.

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Crohn’s disease (CD) is a chronic and relapsing inflammatory bowel disorder that has been shown to generate neurological impairments, which has the potential to signify disease activity in an underlying neurological manner. The objective of this study was to investigate the abnormalities of brain microstructure and the corresponding functional connectivity (FC) in patients with CD, as well as their associations with disease condition. Twenty-two patients with CD and 22 age-, gender-, and education-matched healthy controls (HCs) were enrolled in this study. All subjects underwent mean apparent propagator (MAP)-MRI and resting-state functional magnetic resonance imaging (MRI) (rs-fMRI) data collection. Each patient was evaluated clinically for the condition and duration of the disease. The MAP metrics were extracted and compared between two groups. Pearson’s correlation analysis was conducted to determine the relationship between disease characteristics and significantly abnormal MAP metrics in the CD group. Regions of interest (ROIs) for ROI-wise FC analysis were selected based on their correlation with MAP metrics. Results showed that multiple brain regions, including the parahippocampus and thalamus, exhibited statistically significant differences in MAP metrics between CD patients and HCs. Additionally, CD patients exhibited decreased FC between the left parahippocampus and bilateral thalamus, as well as the right parahippocampus and bilateral thalamus. The findings of this work provide preliminary evidence that structural abnormalities in the parahippocampal gyrus (PHG) and thalamus, as well as decreased FC between them, may reflect the degree of inflammatory of the disease and serve as brain biomarkers for evaluating CD activity.

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Optimization of q-space sampling for mean apparent propagator MRI metrics using a genetic algorithm

Cited by 11 publications

References 30 publications

Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study

Mean Apparent Propagator MRI Is Better Than Conventional Diffusion Tensor Imaging for the Evaluation of Parkinson’s Disease: A Prospective Pilot Study

Laplacian-Regularized Mean Apparent Propagator-MRI in Evaluating Corticospinal Tract Injury in Patients with Brain Glioma

Altered mean apparent propagator-based microstructure and the corresponding functional connectivity of the parahippocampus and thalamus in Crohn’s disease

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