Optimization of pore structure and particle morphology of mesoporous silica for antibody adsorption for use in affinity chromatography

Hikosaka, Ryouichi; Nagata, Fukue; Tomita, Masahiro; Kato, Katsuya

doi:10.1016/j.apsusc.2016.05.016

Cited by 9 publications

(11 citation statements)

References 33 publications

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“…Regarding the functionalization, the MCM-41p material showed the highest binding efficiency. MCM-41p-Me and MCM-41p-SH are good anti-IgG adsorbents; yet, the adsorption efficiency decreases significantly for MCM-41p-Gly, and anti-IgG is poorly adsorbed by MCM-41p-NH2 [64].…”

Section: Silica (Nano)particlesmentioning

confidence: 97%

“…The silica surface can be chemically functionalized with silicon alkoxides, such as methyltriethoxysilane (-Me), 3-mercaptopropyltriethoxysilane (-SH), 3glycidoxypropyltriethoxysilane (-Gly), and 3-aminopropyltriethoxyilane (-NH2) (Fig. 5) [64]. These functionalized surfaces can be further modified with antibodies and proteins [64][65][66][67].…”

Section: Silica (Nano)particlesmentioning

confidence: 99%

“…These functionalized surfaces can be further modified with antibodies and proteins [64][65][66][67]. Hikosaka et al [64] developed an Immunoglobulin G (IgG) purification affinity material based on this strategy, in which four mesoporous silica materials with two morphologies (spherical (MCM-41s and MCM-48s) and polyhedral (MCM-41p and MCM-48p)) were used. After functionalization with different organosilanes, anti-IgG is adsorbed and the FITC-IgG binding efficiency was evaluated.…”

Section: Silica (Nano)particlesmentioning

confidence: 99%

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Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials

Tavares¹,

Neves²,

Trindade³

et al. 2020

Recent Advances in Analytical Techniques: Volume 4

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Biopharmaceuticals main classes comprise recombinant proteins, antibodies, and nucleic-acid-derived products, while synthetic pharmaceuticals include a wide variety of organic compounds. The purification of (bio)pharmaceuticals, as part of downstream processing, is mainly carried out by chromatographic processes, which are responsible for the therapeutics high cost. Therefore, there is a crucial need on the development of novel and more efficient separation/purification processes or on the improvement of the current chromatographic-based ones, aiming at producing pharmaceuticals of high quality and at a lower cost. Amongst alternative techniques, it has been demonstrated that inorganic or organic (nano)particles, used in solid-phase extraction approaches, may be promising for the purification of pharmaceuticals. This chapter provides an overview on solid-liquid separation/purification processes used to obtain high purity and high quality pharmaceuticals. The main purification processes are described and summarized. The areas where there has been a sustainable progress, combined with improved therapeutic characteristics, are highlighted. Materials based on silica (nano)particles, carbon-based (nano)particles (carbon nanotubes, graphene and activated carbon) and magnetic (nano)particles are overviewed. Based on the reported results, nanotechnology may play a key role in future pharmaceutical developments and manufacturing, where the design of suitable functionalized (nano)particles is a crucial factor to enhance the selectivity and to obtain high purification and recovery yields of (bio)pharmaceuticals.

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Section: Silica (Nano)particlesmentioning

confidence: 97%

Section: Silica (Nano)particlesmentioning

confidence: 99%

Section: Silica (Nano)particlesmentioning

confidence: 99%

See 1 more Smart Citation

Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials

Tavares¹,

Neves²,

Trindade³

et al. 2020

Recent Advances in Analytical Techniques: Volume 4

View full text Add to dashboard Cite

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“…Chen et al (2016) analyzed the difference in pore structure of each HFUs based on the fractal theory. Winland r 35 (pore radii at 35% mercury situation during MICP) is use to characterize the HFUs (Nie et al, 2015;Hikosaka et al, 2016;Fu et al, 2017) which can be estimated by the following empirical equation: log r 35 = 0.732 + 0.588 log K − 0.864 log(100φ)…”

Section: Pore Type and Hfusmentioning

confidence: 99%

Applications of digital core analysis and hydraulic flow units in petrophysical characterization

Chen

Zhou

2017

Adv. Geo-Energ. Res.

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Conventional petrophysical characterizations are often based on direct laboratory measurements. Although they provide accurate results, such measurements are time-consuming and limited by instrument and environment. What's more, in the georesource energy industry, availability and cuttings of core plugs are difficult. Because of these reasons, virtual digital core technology is of increasing interest due to its capability of characterizing rock samples without physical cores and experiments. Virtual digital core technology, also known as digital rock physics, is used to discover, understand and model relationships between material, fluid composition, rock microstructure and macro equivalent physical properties. Based on actual geological conditions, modern mathematical methods and imaging technology, the digital model of the core or porous media is created to carry out physical field numerical simulation. In this review, the methods for constructing digital porous media are introduced first, then the characterization of thin rock cross section and the capillary pressure curve using scanning electron microscope image under mixed wetting are presented. Finally, we summarize the hydraulic flow unit methods in petrophysical classification.Keywords: Digital core, porous media, petrophysical characterization, thin section, mercury injection capillary pressure.Citation: Chen, X., Zhou, Y. Applications of digital core analysis and hydraulic flow units in petrophysical characterization. Adv.

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“…Mesoporous silica (MPS) has unique properties, including a controlled, tunable pore size (2-50 nm), large surface area, and large pore volume, and its surface can be easily functionalized [9][10][11][12][13][14][15]. MPS particles were synthesized for the first time in 1992, which open the new application fields as enzyme carriers, columns, absorbents, etc., [16][17][18][19][20]. Generally speaking, increases in the adsorption amount depend on the improvement of the adsorption sites on the adsorbents.…”

Section: Introductionmentioning

confidence: 99%

Effective adsorption of dysprosium ions on amino and carboxyl functionalized mesoporous silica sheets

Kaneko

Hikosaka

Nagata

et al. 2019

Journal of Asian Ceramic Societies

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Securing a stable supply of dysprosium (Dy) is one of the major problems facing the automotive industry due to increased Dy consumption and low-volume production. Investigations of new recycling methods are therefore extremely important. In this study, we focused on mesoporous silica particles (MPS) with tunable nanoscale mesopores (2-50 nm), large surface areas, high pore volumes, and abundant surface chemistry. To perform adsorption experiments with several metal ions in the solution, the silica materials were treated via amino functionalization using silane coupling reagents, 3-aminopropyltriethoxysilane (APTES), N-(2-aminoethyl)-3-aminopropyltriethoxysilane (N2APTES), and N-(6-aminohexyl)-3-aminopropyltrimethoxysilane (N6APTES), as well as via carboxyl functionalization using diglycolic acid. Interestingly, MPS sheet-2HNHCOOH, a product with a sheet-like morphology, exhibited enhanced Dy ion adsorption (13.3 µg/mg). The sheets retained approximately100% in the initial capacity after 10 cycles. The results suggest that MPS sheet-2HNHCOOH is an appropriate a candidate material for selective Dy ion adsorption.

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Optimization of pore structure and particle morphology of mesoporous silica for antibody adsorption for use in affinity chromatography

Cited by 9 publications

References 33 publications

Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials

Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials

Applications of digital core analysis and hydraulic flow units in petrophysical characterization

Effective adsorption of dysprosium ions on amino and carboxyl functionalized mesoporous silica sheets

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