Optimization of polyethylene glycol-based hydrogel rectal spacer for focal laser ablation of prostate peripheral zone tumor

Namakshenas, Pouya; Mojra, Afsaneh

doi:10.1016/j.ejmp.2021.07.034

Cited by 9 publications

(1 citation statement)

References 37 publications

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“…An optimal ablation percentage would be one in which the whole tumor is treated and hyperthermia is applied to the safety margin around it. The temperature thresholds for determining thermal injury to the sensitive organs and coagulative necrosis of the tumor were considered 42 °C and 60 °C, respectively 18 , 28 – 30 . Figure 1 b provides the steps taken for the optimization procedure.…”

Section: Methodsmentioning

confidence: 99%

Optimization of laser dosimetry based on patient-specific anatomical models for the ablation of pancreatic ductal adenocarcinoma tumor

Namakshenas

Matteo

Bianchi

et al. 2023

Sci Rep

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Laser-induced thermotherapy has shown promising potential for the treatment of unresectable primary pancreatic ductal adenocarcinoma tumors. Nevertheless, heterogeneous tumor environment and complex thermal interaction phenomena that are established under hyperthermic conditions can lead to under/over estimation of laser thermotherapy efficacy. Using numerical modeling, this paper presents an optimized laser setting for Nd:YAG laser delivered by a bare optical fiber (300 µm in diameter) at 1064 nm working in continuous mode within a power range of 2–10 W. For the thermal analysis, patient-specific 3D models were used, consisting of tumors in different portions of the pancreas. The optimized laser power and time for ablating the tumor completely and producing thermal toxic effects on the possible residual tumor cells beyond the tumor margins were found to be 5 W for 550 s, 7 W for 550 s, and 8 W for 550 s for the pancreatic tail, body, and head tumors, respectively. Based on the results, during the laser irradiation at the optimized doses, thermal injury was not evident either in the 15 mm lateral distances from the optical fiber or in the nearby healthy organs. The present computational-based predictions are also in line with the previous ex vivo and in vivo studies, hence, they can assist in the estimation of the therapeutic outcome of laser ablation for pancreatic neoplasms prior to clinical trials.

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Section: Methodsmentioning

confidence: 99%