Optimization of Planetary Ball Mill Size on Physicochemical Properties and Dissolution Rate of Nimodipine- PVP K-30

Abstract

Nimodipine is a compound that is insoluble in water and is included in the biopharmaceutical classification system (BCS) class II. This study looks at the characterization of nimodipine-PVP K-30 with the wet grinding method using a planetary ball mill at 200 rpm with large and small ball sizes. Nimodipine was made into 3 formulas, namely a physical mixture (1:0.6), formula 1 with 24 large balls (1:0.6), and formula 2 with 143 small balls (1:0.6). Evaluation of physicochemical properties includes size distribution, surface morphology, functional group analysis, crystallinity properties, thermal properties, assay, and dissolution profile. The dissolution results of nimodipine, CF, F1, and F2 at 60 minutes were 33.63%, 39.48%, 74.00%, and 53.99% respectively. The evaluation results showed that in general nimodipine-PVP K-30 could improve the physicochemical properties and increase the dissolution rate of nimodipine.