Optimization of palm oil in water nano-emulsion with curcumin using microfluidizer and response surface methodology

Raviadaran, Revathi; Chandran, Davannendran; Shin, Liew Huey; Manickam, Sivakumar

doi:10.1016/j.lwt.2018.05.022

Cited by 83 publications

(33 citation statements)

References 39 publications

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“…Improved shelf life, sustained released up to six days, and no release burst of paclitaxel was observed in palm oil lipid nanoemulsion, suggesting high efficacy on cancer cells, compared to the commercially available drug [77]. The stability of nanoemulsion can be analyze by observing the physical changes of the liquid formulations including sedimentation, phase separation, creaming, coalescence or flocculation during the tested period [76][77][78][79][80][81][82][83][84][85][86][87][88].…”

Section: Palm Oil Lipid-based Nanoformulation As a Carrier Systemmentioning

confidence: 99%

An Overview of the Oil Palm Industry: Challenges and Some Emerging Opportunities for Nanotechnology Development

2020

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The increase in the world’s oil demand due to the rise of the global population urges more research into the production of sustainable vegetable oilseeds, among which palm oil is the most suitable candidate as it is the most efficient oilseed crop in the world. In an effort to drive the oil palm industry in the areas of food safety and security nanotechnology could offer a sustainable alternative. However, the utilization of nanotechnology in the oil palm industry is still limited. In this review, we aim to encourage the researchers to fully utilize nanotechnology as an alternative solution to tackle the challenges faced by the oil palm industry. Moreover, we also aim to highlight the opportunities for nanotechnology development in oil palm-based related research. The major points are as follows: (1) Nanosensing enables real-time monitoring of plantation status and crop progression, including soil, water and nutrient management, early pest/disease detection, and the spreading of pests/diseases. The use of nanosensing conveniently extends into advanced breeding topics, such as the development of disease-tolerant plants; (2) Nanotechnology could be the answer for the development of integrated management of pest and disease. Active agricultural ingredients can be entrapped or encapsulated into nanocarrier systems to improve their solubility, stability, enhance their efficient delivery to site-specific targets, with longer shelf life, and consequently improved efficacy; (3) Valuable nanomaterials can be isolated and generated from oil palm biomass waste. The utilization of oil palm biomass waste could overcome the issue of the massive production of waste in the oil palm industry and palm oil mills, where oil only accounts for 10% of the biomass, while 90% is comprised of the generated biowastes. (4) Palm oil can be utilized as a green alternative as a capping and stabilizing agent in the biosynthesis of metallic and non-metallic nanoparticles. In addition, nanoemulsion formulations using palm oil in drug delivery systems offer advantages such as low toxicity, enhance bioavailability and solubility of the drugs, apart from being inexpensive and environmentally friendly.

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Section: Palm Oil Lipid-based Nanoformulation As a Carrier Systemmentioning

confidence: 99%

An Overview of the Oil Palm Industry: Challenges and Some Emerging Opportunities for Nanotechnology Development

2020

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“…Similar to high-pressure homogenization, microfluidization requires multiple recirculation so that the droplets will reach a desired final size (Gothsch et al, 2011;Gupta et al, 2016). Raviadaran, Chandran, Shin, and Manickam (2018) optimized a palm oil-based nanoemulsion to encapsulate curcumin using a microfluidizer and considered the microfluidizer pressure, the number of cycles and the concentration of surfactant (Tween 80) to obtain droplet sizes from 200 nm to 300 nm.…”

Section: Microfluidizer Homogenizationmentioning

confidence: 99%

Development and incorporation of nanoemulsions in food

et al. 2019

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Currently, nanoencapsulation of bioactive compounds is promising, and is one of the methods that has been proven very effective. The development of food-grade nanoemulsions is in a state of constant innovation due to the interesting features that this method of encapsulation has, such as small droplet size, kinetic stability and appearance. With this technology, it is possible to control some food properties, such as texture, taste and stability. In this article, we present a review of the most commonly used methods in the creation of nanoemulsions, the recent developments of these dispersions, the relevant applications of nanoemulsions in food matrices, the most commonly used food-grade materials and the functionality of nanoemulsions, which are designed primarily to encapsulate compounds with biological activity. Nanoemulsions have been shown to be effective in preventing degradation and improving the bioavailability of bioactive compounds, such as oil-soluble vitamins, antimicrobials, flavours and antioxidants. At the end of this article, facts of interest about acceptance issues and nanotechnology regulatory policies in the food industry are presented.

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“…For preparation of bio-based NEs many compounds of natural origin, including encapsulated active ingredients (e.g., essential oils; EOs), but also plant oils for NE oil phase (e.g., palm oil, rapeseed oil, sunflower oil etc.) (e.g., Raviadaran et al 2018;Kaci et al 2018;Abdou et al 2018), emulsifiers, biosurfactants or cosurfactants (e.g., Quillaja saponin, phospholipids, lecithin, gum arabic, pectin, whey protein, lactoferrin, lactoferrin/alginate) McClements and Gumus 2016;Ozturk et al 2014Ozturk et al , 2015Liu et al 2017;Verma et al 2016;Artiga-Artigas et al 2018;Zhao et al 2018a;Pinheiro et al 2016), or targeting ligands on the surface of NE such as folate (Liu et al 2017;Ganta et al 2016;Afzal et al 2016a) increasing drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and thus allowing specific targeting to certain target cells are used. Targeting technology usually utilizes the nanocarrier functionalization, which can be surface modification (e.g., Attia et al 2017;Liu et al 2017) and/or ligand grafting (e.g., Geng et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

Jampílek

Kráľová

Campos

et al. 2019

Nanotechnology in the Life Sciences

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Nanotechnology providing "a new dimension" accompanied with new properties conferred to many current materials is widely used for production of a new generation of agrochemicals, in medicine it enables improved drug bioavailability, reducing undesirable side effects, minimizing non-specific uptake and specific targeting to certain target cells, while in food industry it has great importance in food protection and biofortification of food with valuable ingredients. In biobased nanoemulsions belonging to lipid nanocarriers plant oils used for oil phase, emulsifiers, biosurfactants, cosurfactants, targeting ligands on the surface of nanoemulsion (e.g., folate) or encapsulated active ingredients are of natural origin. The biocomponents of such nanoemulsions show low toxicity to living organisms, could protect encapsulated compounds for degradation, ensure their sustainable release and reduce the amount of active ingredient necessary for required effect. This chapter presents a comprehensive current overview of recent findings in the field of nanoemulsions and their utilization in agriculture and food industry, with the main emphasis on formulations encapsulating essential oils or plant extracts suitable as effective pesticide preparations as well as medicinal applications of bio-based nanoemulsions, where attention is paid to transdermal nanoemulsion formulations, the use of nanoemulsions in cancer therapy and for pulmonary and ocular drug delivery. Nanoemulsions formulated with natural emulsifiers, biosurfactants and biopolymers are presented and bio-based nanoemulsions of essential oils and their constituents as well as nanoemulsions with encapsulated vitamins, fatty acids and some bioactive compounds are discussed. Applications of nanoemulsions in edible coatings are outlined as well.

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Optimization of palm oil in water nano-emulsion with curcumin using microfluidizer and response surface methodology

Cited by 83 publications

References 39 publications

An Overview of the Oil Palm Industry: Challenges and Some Emerging Opportunities for Nanotechnology Development

An Overview of the Oil Palm Industry: Challenges and Some Emerging Opportunities for Nanotechnology Development

Development and incorporation of nanoemulsions in food

Bio-Based Nanoemulsion Formulations Applicable in Agriculture, Medicine, and Food Industry

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