Optimization of Operating Conditions in Individual Airborne Particle Analysis by Inductively Coupled Plasma Mass Spectrometry

Kaneco, Satoshi; Nomizu, Tsutomu; Tanaka, Tomonari; Mizutani, Naoto; Kawaguchi, Hiroshi

doi:10.2116/analsci.11.835

Cited by 35 publications

(29 citation statements)

References 5 publications

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“…The work of Kawaguchi et al [11] utilized generation of monodisperse aerosols containing the dissolved element of interest. Further work from this group, in which aerosols containing Zn and Pb were examined, introduced the use of ICP-MS [13][14][15][16] to improve detection limits. It should be noted that throughout the 1970s and 1980s, numerous other researchers had initiated work that lead to the method of realtime single particle mass spectrometry (RTSPMS), also called continuous aerosol mass spectrometry [17].…”

Section: Need For Advanced Metrology and Historical Contextmentioning

confidence: 99%

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

et al. 2016

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From its early beginnings in characterizing aerosol particles to its recent applications for investigating natural waters and waste streams, single particle inductively coupled plasma-mass spectrometry (spICP-MS) has proven to be a powerful technique for the detection and characterization of aqueous dispersions of metal-containing nanomaterials. Combining the high-throughput of an ensemble technique with the specificity of a single particle counting technique and the elemental specificity of ICP-MS, spICP-MS is capable of rapidly providing researchers with information pertaining to size, size distribution, particle number concentration, and major elemental composition with minimal sample perturbation. Recently, advances in data acquisition, signal processing, and the implementation of alternative mass analyzers (e.g., time-of-flight) has resulted in a wider breadth of particle analyses and made significant progress toward overcoming many of the challenges in the quantitative analysis of nanoparticles. This review provides an overview of spICP-MS development from a niche technique to application for routine analysis, a discussion of the key issues for quantitative analysis, and examples of its further advancement for analysis of increasingly complex environmental and biological samples. Graphical Abstract Single particle ICP-MS workflow for the analysis of suspended nanoparticles.

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Section: Need For Advanced Metrology and Historical Contextmentioning

confidence: 99%

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

et al. 2016

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“…The results show that the DL for 239 Pu is on the order of 10 −8 Bq/m 3 . On-line analysis of artificially generated heavy metal particles using ICP-MS has been reported by Kaneco et al (1995) and Nomizu et al (2002). Results show that the DL for lead and zinc in aerosols are down to sub-femto-gram (fg) level.…”

Section: Introductionmentioning

confidence: 98%

Direct Determination of Ultra-trace Plutonium Nanoparticles in Downstream of a Six-Stage HEPA Filter by Inductively-Coupled-Plasma Mass Spectrometry: A Field Application

Ren

et al. 2011

Aerosol Science and Technology

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In this work, plutonium aerosol generated from a plutonium reprocessing facility is filtered by a six-stage High Efficiency Particulate Air (HEPA) filter system and analyzed in laboratory within a week. Through on-line monitoring of number concentration of particles above 10 nm by a commercial condensation particle counter and off-line monitoring of 239 Pu activity concentration by 242 Pu isotope dilution Inductively-Coupled Plasma Mass Spectrometry (ICP-MS), it is confirmed that the HEPA filter system works properly during the field operation. Direct determination of plutonium aerosol by two types of ICP-MS, Finnigan ELEMENT ICP-MS and Nu MC-ICP-MS, has been conducted. The results show that the detection limits of ELEMENT and Nu for plutonium concentration are 5.0 × 10 −3 Bq/m 3 and 5.5 × 10 −4 Bq/m 3 , respectively. Plutonium concentrations in the filtered gas samples are on the order of 2.0 × 10 −2 Bq/m 3 while the blank value is 5.7 × 10 −3 Bq/m 3. It's discovered that some plutonium nanoparticles have penetrated the six-stage HEPA filter system. This phenomenon is also observed in the repeated works of last two years. The size of the penetrated plutonium nanoparticles is investigated by ELEMENT in single particle mode. The preliminary results indicate that the penetrated plutonium nanoparticles are smaller than 10 nm and assume the form of 239 PuO 2 .

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“…7,38 The calibration curve of ICP-MS intensity versus concentration is converted into ICP-MS intensity versus mass ux of the analyte using the nebulization and transport efficiency. However, the linear dynamic range of the calibration curves of standard particles is 1 to 2 orders of magnitude in particle diameter 5,9,13,16,19,22,23,25,[28][29][30]39 and approximately 3 orders of magnitude in mass only. The rst assumption requires linear calibration curve of the sample particles.…”

Section: Introductionmentioning

confidence: 99%

Calibration of single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS)

Lee

Chan

2015

J. Anal. At. Spectrom.

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We have identified incomplete particle vaporization and non-linear detector response as the major factors that cause the non-linearity of SP-ICP-MS measurements at high particle mass. The contribution of incomplete vaporization to the deviation from the linearity of the ICP-MS intensity is estimated using a mathematical model of particle vaporization. The non-linear detector response in the pulse-counting mode is due to the overlapping of the analyte ions at the detector within the 40 ns dead time of the electron multiplier. The overlap can be severe because of the relatively short pulse duration of 300 ms of the ion plumes of the discrete sample particles. The non-linear detector response has been modeled using Poisson statistics. We have also examined the applicability of calibration methods based on the standard particles, discrete standard solution droplets, and continuous nebulization of standard solution. The standard-solution calibration method requires linear calibration curves. The method may also suffer from errors due to the difference in the sensitivity of the standard solution and sample particles.Calibration using standard particles and discrete standard solution droplets do not have these limitations.

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Optimization of Operating Conditions in Individual Airborne Particle Analysis by Inductively Coupled Plasma Mass Spectrometry

Cited by 35 publications

References 5 publications

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

Single Particle ICP-MS: Advances toward routine analysis of nanomaterials

Direct Determination of Ultra-trace Plutonium Nanoparticles in Downstream of a Six-Stage HEPA Filter by Inductively-Coupled-Plasma Mass Spectrometry: A Field Application

Calibration of single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS)

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