Optimization of Nanoemulgel Formula of Gold Particle-Vitamin E and in Vivo Test

Abstract

Gold is a substance that can be used as a collagen forming catalyst, it can help regenerate the skin. Vit. E is a natural antioxidant compound that can be used to help regenerate and brighten the skin. Gold is a metal so it is difficult to apply into the skin. Gold and vit. E are formulated with SNEDDS (Self Nano Emulsifying Drugs Delivery System) technique, in order to reduce the size and dispersing of gold particles homogeneously. SNEDDS formula consists of olive oil, tween 80 (surfactant), propylene glycol (co-surfactant), vit. E and gold particles, which are optimized to obtain the optimum component using the D-Optimal method. Software will obtain 16 run formulas with difference composition of olive oil, tween 80, and propylene glycol. Transmittance value and pH as response. Loading dose capability was also carried out. Verification with statistical analysis using one sample t-test and then evaluated particle size, polydispersity index, and zeta potential. SNEDDS gold-Vit E optimum formula then dispersed into matrix hydrogel (Carbopol). The formula of Nanoemulgel gold was evaluated for physical properties and in vivo tests compared with brand gold cosmetic. The optimum composition of olive oil (9,09%), tween 80 (80,62%), and propylene glycol (10,29%) with loading dose of 2,6 mg gold and 250 µL of vitamin E. Characterization results showed the transmittance value is 97,22±0,06% and pH is 6,72±0,04 which shows no significant difference (p> 0,05) between the observation and software prediction. The results of SNEDDS evaluation showed a particle size of 150,2 nm, PI of-0,52 and potential zeta-24,9 mV. The results of stability test of nanoemulgel showed a semisolid, broken white colour, transparent, odorless, homogeneous. pH value of 6,78±0,06; viscosity of 346,67±15,27 dPas; and spread test of 5,48±0,035 cm. The results of the in vivo test showed that on the 6th day there was a significant skin regeneration when compared to brand product.

Enhancement of Curcumin Anti-Inflammatory Effect via Formulation into Myrrh Oil-Based Nanoemulgel

“…Accordingly, the particle sizes of emulgel and nanoemulgel demonstrated a good distribution and fell within a narrow range of sizes. Our findings are in agreement with Ermawati et al, who showed a particle size of 150 nm for the formulation of nanoemulgel gold [ 41 ]. Moreover, Dhawan et al, recorded the particle size of piroxicam nanoemulgel to be within the nano size range (125 nm) [ 42 ].…”

Effect of the combination of Alpha-Cellulose and Polyvinyl Alcohol on physicochemical properties of Moringa oleifera leaves ethanolic extract patch and release test

“…The thickness of the patch film affects the permeability of the drug to penetrate the film. The thicker film will reduce the permeability of the drug through the film and the coefficient of drug permeability through the film [7]. Patch thickness also affects the fragility of the patch.…”

“…The results of the analysis show that the variation ratio of PVA and alpha-cellulose polymers in Moringa oleifera leave ethanolic extract patch have no significant effect on the pH value between the patch formulas. High Moisture content caused patches to be easily overgrown with fungi and bacteria [7]. The moisture content test using a moisture analyzer.…”

“…In the patch formulation with the matrix system, a polymer is the main constituent component. Polymers in the matrix system play a controlling role in drug release from the patch matrix [7]. Hydrophilic and hydrophobic polymers are two kinds of polymers used in patch preparations.…”