Optimization of molecular distillation to concentrate ethyl esters of eicosapentaenoic (20:5 ω-3) and docosahexaenoic acids (22:6 ω-3) using simplified phenomenological modeling

Abstract

The theoretical model and the optimization give decision criteria about the operative conditions for reaching the highest yield during molecular distillation of ω-3 fatty acid ethyl esters.

The use of artificial neural network modeling to represent the process of concentration by molecular distillation of omega-3 from squid oil

“…To construct and validate the ANN predictive model experimental data were used from Rossi et al (2011) along with theoretical concepts based on phenomenological laws.…”

“…Rossi et al (2011) reported the EE composition squid Illex argentinus oil analyzed by gas chromatography. In that study, several fatty acids in significant amounts were detected.…”

“…Particularly in fish oils, there are two omega-3 fatty acids, 5,8,11,14,20:5ω3) and 4,7,10,13,16,22:6ω3) that are functional constituents of importance for the physiology of the human body (Swanson, 2012). Rossi et al (2011) optimized the separation process of omega-3 fatty acid ethyl esters obtained from calamari oils using molecular distillation. The separation process was conducted in two stages where operation temperatures ranged from 100 to 120 °C in the first stage and from 120 to 140 °C in the second stage.…”

Distillation of Natural Fatty Acids and Their Chemical Derivatives

“…Separating the oil's components by weight allows contaminates to be reduced far below industry standards. Current industrial applications include cosmetic applications, the concentration of omega-3 fatty acids (EPA and DHA) and corresponding esters in fish oil (Rossi et al, 2011), and contaminant removal. Additionally, Vitamin E (Pramparo et al, 2005), Vitamin A, cocoa butter, dimer acids, epoxy resins, lubricants, monoglycerides, insecticides, pharmaceuticals, perfumery and flavours, essential oils, Azadirachtin (Neem based pesticides) and its formulations as well as many other natural & herbal products have been distilled on an industrial scale using this process.…”

“…Many reports on the molecular distillation of fatty acid esters from sunflower and soybean esters (Pramparo et al, 2005), rapeseed fatty acid esters and tocopherols (Jiang et al, 2006), eicosapentaenoic (EPA) and docosahexaenoic acid ethyl esters (Brevik et al, 1997), and squid visceral oil ethyl esters (Liang & Hwang, 2000;Rossi et al, 2011) have been reported. Vázquez and Akoh (2010) reported a detailed study on the fractionation of short and medium chain fatty acid ethyl esters via short-path distillation that were obtained from a blend of coconut oil and dairy fat.…”