Optimization of Metronidazole Emulgel

Abstract

The purpose of the present study was to develop and optimize the emulgel system for MTZ (Metronidazole), a poorly water soluble drug. The pseudoternary phase diagrams were developed for various microemulsion formulations composed of Capmul 908 P, Acconon MC8-2, and propylene glycol. The emulgel was optimized using a three-factor, two-level factorial design, the independent variables selected were Capmul 908 P, and surfactant mixture (Acconon MC8-2 and gelling agent), and the dependent variables (responses) were a cumulative amount of drug permeated across the dialysis membrane in 24 h (Y 1) and spreadability (Y 2). Mathematical equations and response surface plots were used to relate the dependent and independent variables. The regression equations were generated for responses Y 1 and Y 2. The statistical validity of the polynomials was established, and optimized formulation factors were selected. Validation of the optimization study with 3 confirmatory runs indicated a high degree of prognostic ability of response surface methodology. Emulgel system of MTZ was developed and optimized using 23 factorial design and could provide an effective treatment against topical infections.

Emulgel based topical delivery system for loratadine

“…Spreadability study. Conventionally, spreadability of a formulation is inversely related to its viscosity [28]. However, in our study the outcomes of the spreadability testing differ from the general argument.…”

Development and evaluation of Metronidazole containing topical gel using different gelling agents

“…1g of gel was dissolved in 25 ml of distilled water in a beaker. Then the electrode was dipped into the beaker solution and allowing it to equilibrium for 1 min and constant reading was noted (Ciurba et al, 2015;Rao et al, 2013).…”

Nanoemulgel, an Innovative Carrier for Diflunisal Topical Delivery with Profound Anti-Inflammatory Effect: in vitro and in vivo Evaluation

“…For the preparation of the gel base of XG, 3% of XG was added in purified water and stirred continuously to form an homogeneous base, followed by pH adjustment with triethanolamine. 19 The gel bases of the other two gelling agents were made by dissolving 3% of both CMC-Na and Na-ALG in defined volumes of water by stirring for a period of 2 hand finally adjusting their pH. 20 The three different gel bases were mixed with the optimized NE formulae separately in 1:1 by magnetic stirring at 250 rpm for about 15 min until smooth and viscous nanoemulsion-based gels were formed.…”