Optimization of mechanical property, antibacterial property and corrosion resistance of Ti-Cu alloy for dental implant

Wang, Jiewen; Zhang, Shuyuan; Sun, Zhizeng; Wang, Hai; Ren, Ling; Yang, Ke

doi:10.1016/j.jmst.2019.03.044

Cited by 102 publications

(36 citation statements)

References 35 publications

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“…In this study, it is found that the Ti-3wt%Cu alloys under different conditions exhibit excellent antibacterial ability ([ 95%) according to our antibacterial evaluation results, which is an significant improvement compared with previous reports on the Ti-3wt%Cu alloy without rolling and annealing [28,29]. The antibacterial mechanism of Cubearing phase is not yet fully revealed; however, possible mechanisms such as nucleic acids and lipids, oxidation of cell proteins, inhibition of biofilm, damaging DNA and various essential cell reactions have been proposed [30][31][32][33][34][35]. According to theses mechanisms, the improved antibacterial ability can be resulted from increasing effective contact, which can inhibit bacteria adhesion on the surface and avoid the formation of bacterial biofilm [36].…”

Section: Effect Of Ti 2 Cu Phase On Antibacterial Propertysupporting

confidence: 53%

Optimization of mechanical and antibacterial properties of Ti-3wt%Cu alloy through cold rolling and annealing

Yang

Zhu

et al. 2021

Rare Met.

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In this work, a process of cold rolling with 70% thickness reduction and different annealing temperatures was selected to regulate the microstructure of Ti-3wt%Cu alloy. Microstructural evolution, mechanical properties and antibacterial properties of the Ti-3wt%Cu alloy under different conditions were systematically investigated in terms of X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM), tensile and antibacterial test. The results indicated that cold rolling could dramatically increase the ultimate tensile stress (UTS) from 520 to 928 MPa, but reduce the fracture strain from 15.3% to 3.8%. With the annealing temperature increasing from 400 to 800 °C for 1 h, the UTS decreased from 744 to 506 MPa and the fracture strain increased from12.7% to 24.4%. Moreover, the antibacterial properties of the Ti-3wt%Cu alloy under different conditions showed excellent antibacterial rate ([ 96.69%). The results also indicated that the excellent combination of strength and ductility of the Ti-3wt%Cu alloy with cold rolling and following annealing could be achieved in a trade-off by tuning the size and distribution of Ti 2 Cu phase, which could increase the applicability of the alloy in clinical practice. More importantly, the antibacterial properties maintained a good stability for the Ti-3wt%Cu alloy under different conditions. The excellent combination of mechanical properties and antibacterial properties could make the Ti-3wt%Cu alloy a good candidate for long-term orthopaedic implant application.

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Section: Effect Of Ti 2 Cu Phase On Antibacterial Propertysupporting

confidence: 53%

Optimization of mechanical and antibacterial properties of Ti-3wt%Cu alloy through cold rolling and annealing

Yang

Zhu

et al. 2021

Rare Met.

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“…Thus Cu has been added to various metal materials, for example, Cu‐bearing stainless steel (Ren, Zhu, Nan, & Yang, 2011; Q. Wang et al, 2016), Cu‐bearing cobalt‐based alloy (Lu et al, 2018), Cu‐bearing titanium alloy (Peng, Zhang, Sun, Ren, & Yang, 2018), and so forth. The addition of Cu could improve antibacterial (J. W. Wang, Zhang, et al, 2019), anti‐infection(X. Y. Wang, Dong, et al, 2019), bone healing (Liu et al, 2018), endothelialization (Harris, 2014), and vascularization (Niu et al, 2016; J. Y. Wang, Wang, et al, 2019) properties. Also, Cu was added to polymer materials by methods, including physical blending (Tabesh, Salimijazi, Kharaziha, & Hejazi, 2018) and chemical bonding (Li et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter

et al. 2020

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Vascular implant interventional medical catheter will contact with blood firstly after implantation. The anticoagulation and antibacterial functions of this device will determine the success or failure. Copper (Cu) has been verified to possess multi‐biofunctions, but it was challenging to add the Cu metal to most materials. Take advantage of its functionality; Cu has been grafted on the material surface to improve the anticoagulation function and accelerate endothelialization. In this study, a Cu‐bearing chitosan coating was prepared on the catheter to endow the anticoagulation and anti‐infection functions. Besides, properties characterization and functional evaluation of the coated medical catheter were investigated. Dynamic blood clotting and platelet adhesion tests were carried out to evaluate the anticoagulation property. Besides this, the antibacterial test was used to estimate the anti‐infection function. The surface energy and Cu ions release from the coating were detected and calculated by contact angles and immersion tests, respectively. The results of attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR) and X‐ray photoelectron spectroscopy (XPS) revealed that Cu ions were grafted in the chitosan coating. Thermogravimetric analysis (TA) result showed the concentration of Cu ions in the coating. The results of dynamic blood clotting, platelet adhesion, and antibacterial tests revealed that Cu grafted in chitosan would improve the blood compatibility and anti‐infection property. The surface properties and Cu ions release behavior of Cu‐bearing coating revealed the reasons for multi‐biofunctions. This study indicated that the Cu‐bearing chitosan coating could endow the vascular implant interventional device anticoagulation and anti‐infection functions, which has excellent potential for clinical application.

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“…However, the high risk of crack formation at the coating layer and dental implant interface introduces undesirable deficiencies during the manufacturing process. These deficiencies may be improved using functionally graded material (FGM) implants; however, it is challenging to develop biomaterials that are both biologically and mechanically compatible [10]. Titanium (Ti) has exhibited low density, high mechanical strength, and good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

In Vivo and In Vitro Analyses of Titanium-Hydroxyapatite Functionally Graded Material for Dental Implants

Wang

Wan

Feng

et al. 2021

BioMed Research International

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Purpose. The stress shielding effect caused due to the mechanical mismatch between the solid titanium and the surrounding bone tissue warrants the utilization of a mechanically and biologically compatible material such as the titanium-hydroxyapatite (Ti-HA) functionally graded material (FGM) for dental implants. This study is aimed at fabricating a Ti-HA FGM with superior mechanical and biological properties for dental implantation. Materials and Methods. We fabricated a Ti-HA FGM with different Ti volume fractions (VFs) using HA and Ti powders. Ti-HA was characterized by studying its mechanical properties. Cytotoxicity was examined using a Cell Counting Kit-8 assay and an LDH cell cytotoxicity assay. Scanning electron microscopy was performed on an XL30 environmental scanning electron microscope (ESEM). Alkaline phosphatase (ALP) and transforming growth factor (TGF-β1) expressions were quantitatively monitored using enzyme-linked immunosorbent assay (ELISA) kits. The expressions of TGF-β receptors and ALP genes were measured using real-time polymerase chain reaction. The Ti-HA FGM dental implants were placed in beagle dogs. Microcomputed tomography (CT) and hard tissue slices were performed to evaluate the bone-implant contact (BIC) and bone volume over total volume (BV/TV). Results. The density and mechanical properties of the Ti-HA exhibited various graded distributions corresponding to VF. Based on the results of the Cell Counting Kit-8 (CCK-8) and lactate dehydrogenase (LDH) assays, the difference in cytotoxicity between the two groups was statistically nonsignificant ( P = 0.11 ). The ALP and TGF-β1 levels were slightly upregulated. The transcript levels of ALP and TGF-βRI were higher in the Ti-HA groups than in the Ti group at 7 days, whereas the transcript levels of TGF-βRII exhibited no obvious increase. The BIC did not exhibit significant differences between the Ti and Ti-HA FGM groups ( P = 0.0504 ). BV/TV showed the Ti-HA FGM group had better osteogenesis ( P = 0.04 ). Conclusion. Ti-HA FGM contributes to the osteogenesis of dental implants in vivo and in vitro.

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Optimization of mechanical property, antibacterial property and corrosion resistance of Ti-Cu alloy for dental implant

Cited by 102 publications

References 35 publications

Optimization of mechanical and antibacterial properties of Ti-3wt%Cu alloy through cold rolling and annealing

Optimization of mechanical and antibacterial properties of Ti-3wt%Cu alloy through cold rolling and annealing

Anticoagulation and antibacterial functional coating on vascular implant interventional medical catheter

In Vivo and In Vitro Analyses of Titanium-Hydroxyapatite Functionally Graded Material for Dental Implants

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