Titanium alloys are utilized in many engineering fields such as chemical, industrial, marine, and aerospace due to their unique properties. Machining of these materials causes severe problems. At high temperatures, they become chemically active and tend to react with tool materials. In the present study, fuzzy logic (a tool in artificial intelligence) is used for the prediction of cutting parameters in turning titanium alloy (Ti-6Al-4V). The parameters considered in this study are cutting speed, feed, and the depth of cut. Fuzzy rule-based modeling is employed for prediction of tool flank wear, surface roughness, and specific cutting pressure in machining of titanium alloy. These models can be effectively used to predict the tool flank wear, surface roughness, and specific cutting pressure in machining of titanium alloys. Analysis of the influences of the individual important machining parameters on the responses have been carried out and presented in this study.