Optimization of light illumination for photoacoustic computed tomography of human infant brain

Mahmoodkalayeh, Sadreddin; Lu, Xihong; Ansari, Mohammad Ali; Li, Hengguang; Avanaki, Kamran

doi:10.1117/12.2291592

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Photoacoustic imaging (PAI) is a promising imaging technique that combines higher imaging contrast of optical imaging with deeper penetration of ultrasonic imaging [1][2][3]. A nanosecond pulsed laser deposits energy onto a light absorbing sample, causing a local temperature increase and subsequent thermal expansion through the thermoacoustic effect [2,[4][5][6][7][8]. This expansion causes a localized pressure increase, which propagates from the sample to be imaged, by an ultrasound transducer, similar to a traditional ultrasound detection system.…”

Section: Introductionmentioning

confidence: 99%

“…The waves around the tissue are collected by wideband ultrasound transducers, placed in the same plane, at radially symmetric angles, and ideally equidistant from the imaging target [25]. The detection scheme can be realized either by a single ultrasound transducer rotating around the sample, or a stationary ring array of 128, 256, or greater number of transducer elements [7,26,27]. Such configuration offers a fast image acquisition, but requires an expensive hardware and data acquisition unit.…”

Section: Introductionmentioning

confidence: 99%

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Development of Low-Cost Fast Photoacoustic Computed Tomography: System Characterization and Phantom Study

et al. 2019

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A low-cost Photoacoustic Computed Tomography (PACT) system consisting of 16 single-element transducers has been developed. Our design proposes a fast rotating mechanism of 360o rotation around the imaging target, generating comparable images to those produced by large-number-element (e.g., 512, 1024, etc.) ring-array PACT systems. The 2D images with a temporal resolution of 1.5 s and a spatial resolution of 240 µm were achieved. The performance of the proposed system was evaluated by imaging complex phantom. The purpose of the proposed development is to provide researchers a low-cost alternative 2D photoacoustic computed tomography system with comparable resolution to the current high performance expensive ring-array PACT systems.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of Low-Cost Fast Photoacoustic Computed Tomography: System Characterization and Phantom Study

et al. 2019

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“…4,12,[14][15][16][17][18][19][20] We have also implemented several optimization algorithms for wavefront shaping purposes. [21][22][23][24][25][26][27] In this study, we compare the performance of six of these optimization algorithms: Continuous Sequential (CS) algorithm, Partitioning Algorithm (PA), Transmission Matrix (TM) estimation method, Particle Swarm Optimization (PSO) method, Genetic Algorithm (GA) and Simulated Annealing (SA) algorithm in terms of their enhancement, stability and initial convergence speed. We have developed these algorithms and evaluated them.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of optimization algorithms for wavefront shaping

Fayyaz

Mohammadian

Tabar

et al. 2019

J. Innov. Opt. Health Sci.

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By manipulating the phase map of a wavefront of light using a spatial light modulator, the scattered light can be sharply focused on a speci¯c target. Several iterative optimization algorithms for obtaining the optimum phase map have been explored. However, there has not been a comparative study on the performance of these algorithms. In this paper, six optimization algorithms for wavefront shaping including continuous sequential, partitioning algorithm, transmission matrix estimation method, particle swarm optimization, genetic algorithm (GA), and simulated annealing (SA) are discussed and compared based on their e±ciency when introduced with various measurement noise levels.

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“…Finally, depending on the configuration of As for light illumination, an overhead illumination using a single large optical fiber or a full-field illumination using a fiber bundle, have been studied [15,36,37]. We have previously shown in [38,39] that full-field illumination provides a more homogenous and deeper illumination than overhead illumination; using full-field illumination, we have access to a larger illumination area, and according to the literature [40], the larger the area of illumination, the more light we can couple to the tissue. This issue is of paramount importance especially in the areas of brain and breast imaging where there is a need for a large amount of fluence inside the tissue, which is to be maintained below the tissue damage threshold.…”

Section: Introductionmentioning

confidence: 99%

Development of a Stationary 3D Photoacoustic Imaging System Using Sparse Single-Element Transducers: Phantom Study

et al. 2019

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Photoacoustic imaging (PAI) is an emerging label-free and non-invasive modality for imaging biological tissues. PAI has been implemented in different configurations, one of which is photoacoustic computed tomography (PACT) with a potential wide range of applications, including brain and breast imaging. Hemispherical Array PACT (HA-PACT) is a variation of PACT that has solved the limited detection-view problem. Here, we designed an HA-PACT system consisting of 50 single element transducers. For implementation, we initially performed a simulation study, with parameters close to those in practice, to determine the relationship between the number of transducers and the quality of the reconstructed image. We then used the greatest number of transducers possible on the hemisphere and imaged copper wire phantoms coated with a light absorbing material to evaluate the performance of the system. Several practical issues such as light illumination, arrangement of the transducers, and an image reconstruction algorithm have been comprehensively studied.

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Optimization of light illumination for photoacoustic computed tomography of human infant brain

Cited by 10 publications

References 16 publications

Development of Low-Cost Fast Photoacoustic Computed Tomography: System Characterization and Phantom Study

Development of Low-Cost Fast Photoacoustic Computed Tomography: System Characterization and Phantom Study

A comparative study of optimization algorithms for wavefront shaping

Development of a Stationary 3D Photoacoustic Imaging System Using Sparse Single-Element Transducers: Phantom Study

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