Optimization of laboratory diagnostics of neuromyelitis optica spectrum disorders: indications and algorithms

Abstract

Neuromyelitis optica spectrum disorders are a group of autoimmune demyelinating diseases of the central nervous system characterized by severe exacerbations with development of residual neurological deficit. Anti-aquaporin-4 antibody is one of key factor in diagnosing, differentiating, and prescribing pathogenetic therapy. The paper discusses tests and methods of detecting anti-aquaporin-4 antibodies.