Optimization of iterative reconstruction parameters with 3-dimensional resolution recovery, scatter and attenuation correction in 123I-FP-CIT SPECT

Matsutomo, Norikazu; Nagaki, Akio; Yamao, Fusae; Sasaki, Masayuki

doi:10.1007/s12149-015-0987-1

Cited by 17 publications

(19 citation statements)

References 16 publications

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“…The present study showed that the SBRs calculated by images without ACSC reconstruction were lower than those calculated by images reconstructed with CTACSC, CTAC, or Chang AC, which is in accordance with the results of the previous studies. [ 8 – 11 ] Matsutomo et al [ 8 ] reported that the quality of the SPECT images reconstructed by OSEM with CTACSC was superior to that reconstructed by filtered back projection (FBP) with Chang AC, and the diagnostic ability of DSND by the former appeared to be superior to the latter even though the difference was not statistically significant. Lange et al [ 10 ] compared the effect of OSEM with CTAC, Chang AC, and no AC on the SBRs.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, with recent increasing availability of hybrid SPECT/computed tomography (CT) scanners, several studies have compared a conventional uniform AC method like Chang with a nonuniform AC method like CT attenuation correction (CTAC). [ 8 – 11 ] Although the phantom data indicated that CTAC improved recovery of the tracer accumulation in the striata, increased the SBR, and enhanced the image quality of I-123 FP-CIT SPECT, [ 8 , 9 ] the utility of these corrections in clinical practice is still under debate. [ 10 , 11 ]…”

Section: Introductionmentioning

confidence: 99%

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Attenuation and scatter correction in I-123 FP-CIT SPECT do not affect the clinical diagnosis of dopaminergic system neurodegeneration

Akahoshi¹,

Abe²,

Uchiyama

et al. 2017

Medicine

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The purpose of this study was to assess the influence of different reconstruction factors in N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-I-123 iodophenyl)nortropane (I-123 FP-CIT) single-photon emission computed tomography (SPECT) images for the diagnosis of dopaminergic system neurodegeneration (DSND).Seventy-three patients (38 females, 35 males) suspected of DSND were included in this study. The patients were divided into 3 groups on the basis of their final clinical diagnoses; patients with Parkinson disease (group 1, n = 36), patients with other DSND (group 2, n = 19), patients without DSND (group 3, n = 18). FP-CIT accumulation in the striata was evaluated visually and semiquantitatively. SPECT images were classified visually as normal or abnormal based on the previous report. For semiquantitative analysis, we used DaTView software (Aze Corporation), and specific binding ratios (SBR) and asymmetry indices (AI) were calculated. Visual and semiquantitative evaluations for different reconstruction factors were compared among the 3 groups.In the visual evaluation, there were no differences among DSND diagnostic capabilities of attenuation and scatter correction by computed tomography attenuation correction scatter correction, computed tomography attenuation correction, Chang attenuation correction, and non-attenuation and -scatter correction. In the semiquantitative evaluation, receiver operating characteristic analysis of SBR and AI for clinical DSND diagnostic ability (group 1+2 vs 3) showed no significant difference among the reconstruction factors by multiple comparisons.Although the values of SBR and AI were changed and image quality could be improved when attenuation correction and/or scatter correction were applied, the clinical impact of these reconstruction factors for the diagnosis of DSND was negligible.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attenuation and scatter correction in I-123 FP-CIT SPECT do not affect the clinical diagnosis of dopaminergic system neurodegeneration

Akahoshi¹,

Abe²,

Uchiyama

et al. 2017

Medicine

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“…Next, the six sealed pieces in the columnar part were filled with 123 I aqueous solutions of 80, 40, 20, 10, and 5 kBq/mL, 19,20 as well as one with only water. The surrounding volume was sealed with a 2.5 kBq/mL 123 I aqueous solution as the background.…”

Section: Equipment/methodsmentioning

confidence: 99%

Experimental evaluation of the GE NM/CT 870 CZT clinical SPECT system equipped with WEHR and MEHRS collimator

Ito¹,

Matsusaka

Onoguchi

et al. 2021

J Applied Clin Med Phys

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Purpose A high‐energy‐resolution whole‐body SPECT‐CT device (NM/CT 870 CZT; C‐SPECT) equipped with a CZT detector has been developed and is being used clinically. A MEHRS collimator has also been developed recently, with an expected improvement in imaging accuracy using medium‐energy radionuclides. The objective of this study was to compare and analyze the accuracies of the following devices: a WEHR collimator and the MEHRS collimator installed on a C‐SPECT, and a NaI scintillation detector‐equipped Anger‐type SPECT (A‐SPECT) scanner, with a LEHR and LMEGP. Methods A line phantom was used to measure the energy resolutions including collimator characteristics in the planar acquisition of each device using 99mTc and 123I. We also measured the system's sensitivity and high‐contrast resolution using a lead bar phantom. We evaluated SPECT spatial resolution, high‐contrast resolution, radioactivity concentration linearity, and homogeneity, using a basic performance evaluation phantom. In addition, the effect of scatter correction was evaluated by varying the sub window (SW) employed for scattering correction. Results The energy resolution with 99mTc was 5.6% in C‐SPECT with WEHR and 9.9% in A‐SPECT with LEHR. Using 123I, the results were 9.1% in C‐SPECT with WEHR, 5.5% in C‐SPECT with MEHRS, and 10.4% in A‐SPECT with LMEGP. The planar spatial resolution was similar under all conditions, but C‐SPECT performed better in SPECT acquisition. High‐contrast resolution was improved in C‐SPECT under planar condition and SPECT. The sensitivity and homogeneity were improved by setting the SW for scattering correction to 3% of the main peak in C‐SPECT. Conclusion C‐SPECT demonstrates excellent energy resolution and improved high‐contrast resolution for each radionuclide. In addition, when using 123I, careful attention should be paid to SW for scatter correction. By setting the appropriate SW, C‐SPECT with MEHRS has an excellent scattered ray removal effect, and highly homogenous imaging is possible while maintaining the high‐contrast resolution.

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“…The radioactivity concentration of the background was set to 5.56 or 7.44 kBq/mL. The simulation settings were based on the imaging guidelines of DaT-SPECT and a previous study [15][16][17]. The main energy window was 143-175 keV (159 keV ± 20%).…”

Section: Simulation Code and Phantommentioning

confidence: 99%

Impact of Collimator on DaT-SPECT Imaging: Monte Carlo Simulation Study

Takahashi¹,

Himuro²,

Funada³

et al. 2020

RDI

Self Cite

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Aim: The purpose of this study was to assess the impact of the collimator in viewing the dopamine transporter, using 123I ioflupane single-photon emission computed tomography (DaT-SPECT) images utilizing a Monte Carlo simulation. Methods: For the purpose of this study, the Monte Carlo simulation of electrons and photons (MCEP)- SPECT was used. A numerical phantom was created from a real basal ganglia phantom and installed within the code. The specific binding ratios (SBRs) were 5.03 and 2.01 for the background concentration of 7.44 kBq/mL or 7.04 and 3.03 for a background concentration of 5.56 kBq/mL. The simulated images were evaluated using a recovery coefficient (RC). Initially, we simulated the performance of 14 collimators without resolution correction to investigate the impact of the collimator dimension. The effects of two resolution correction methods (collimator broad correction (CBC) and three-dimensional frequency– distance relationship (3D-FDR)) on two reconstruction methods (Ordered-Subsets Expectation Maximization (OSEM) and Filtered back projection (FBP)) was assessed for collimators that demonstrated a better RC value. Results: Five low-energy high-resolution (LEHR) collimators and one medium-energy general-purpose (MEGP) collimator demonstrated superior RC values. These collimators had a high aspect ratio (holelength/hole-diameter). The maximum RC value without resolution correction was 64.9% when the image was reconstructed with OSEM. The RC value improved to 79.7% when the resolution correction of CBC was applied. When the resolution collection was applied, the RCs improved by approximately 1.2 times when compared against those without the resolution correction. In terms of the reconstruction method, the RC obtained using OSEM was statistically insignificant when compared to the RC using FBP. The difference in the RC value with collimators decreased according to resolution correction. Conclusion: The LEHR collimator with a high aspect ratio, and the OSEM with spatial resolution correction were confirmed to be appropriate for DaT-SPECT imaging. In terms of the reconstruction method, CBC was more favourable than FDR.

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Optimization of iterative reconstruction parameters with 3-dimensional resolution recovery, scatter and attenuation correction in 123I-FP-CIT SPECT

Cited by 17 publications

References 16 publications

Attenuation and scatter correction in I-123 FP-CIT SPECT do not affect the clinical diagnosis of dopaminergic system neurodegeneration

Attenuation and scatter correction in I-123 FP-CIT SPECT do not affect the clinical diagnosis of dopaminergic system neurodegeneration

Experimental evaluation of the GE NM/CT 870 CZT clinical SPECT system equipped with WEHR and MEHRS collimator

Impact of Collimator on DaT-SPECT Imaging: Monte Carlo Simulation Study

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