Optimization of hybrid microfluidic chip fabrication methods for biomedical application

Kojić, Sanja; Birgermajer, Slobodan; Radonić, Vasa; Podunavac, Ivana; Jevremov, Jovana; Petrović, Bojan; Marković, Evgenija; Stojanović, Goran M.

doi:10.1007/s10404-020-02372-0

Cited by 13 publications

(12 citation statements)

References 36 publications

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“…Xurography represents the patterning of an adhesive film through the use of a razor blade [ 57 ]. It was adapted as a low-cost technique for microfluidic chip fabrication, because it allows the production of robust, inexpensive devices in a short time (several minutes) and without requiring a cleanroom facility [ 57 , 66 , 68 ].…”

Section: Fabrication Of Microfluidic Devicesmentioning

confidence: 99%

“…Fused deposition modeling is based on the melting of a thermoplastic filament, followed by its extrusion through a nozzle and solidification by cooling [ 35 ]. The method is simple, effective, and affordable, allowing for multi-material printing [ 35 , 68 ]. However, some challenges must also be considered when deciding whether fused deposition modeling is suitable for specific microfluidic chips.…”

Section: Fabrication Of Microfluidic Devicesmentioning

confidence: 99%

“…Another hybrid technology was proposed by Kojic et al [ 68 ], who integrated the benefits of xurography and thermal lamination into a 3D prototyping printing process. Their fabrication method enabled rapid and robust manufacturing, with the potential of scaling-up the process by parallelizing the whole procedure.…”

Section: Fabrication Of Microfluidic Devicesmentioning

confidence: 99%

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Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

347

208

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Microfluidics is a relatively newly emerged field based on the combined principles of physics, chemistry, biology, fluid dynamics, microelectronics, and material science. Various materials can be processed into miniaturized chips containing channels and chambers in the microscale range. A diverse repertoire of methods can be chosen to manufacture such platforms of desired size, shape, and geometry. Whether they are used alone or in combination with other devices, microfluidic chips can be employed in nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture. This paper presents microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices.

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Section: Fabrication Of Microfluidic Devicesmentioning

confidence: 99%

Section: Fabrication Of Microfluidic Devicesmentioning

confidence: 99%

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Fabrication and Applications of Microfluidic Devices: A Review

Niculescu

Chircov

Bîrcă

et al. 2021

IJMS

347

208

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“…Some of the commonly used technologies are realizing MF chips in glass [27], PMMA [28], low-temperature, co-fired ceramics (LTCC) [29], 3D printing [30], paper [31] etc. In addition, different hybrid fabrication technologies have been developed by combining different materials and technologies [32,33]. The technology described in this paper uses transparent, biocompatible polymer PMMA, which showed ability for rapid and precise laser manufacturing.…”

Section: Discussionmentioning

confidence: 99%

Microfluidic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2

et al. 2021

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Miniaturization of different measurement processes and a scaled-down approach open the possibility for rapid measurements with the small amounts of samples and reagents into a compact platform with integrated sensors and different measuring components. In this paper, we report a microfluidic approach for measurements of salivary pH, dissolved O2, and CO2 during chewing xylitol gum. The study was done with the samples of 30 healthy volunteers who were chewing a xylitol gum, and the measurements were performed in the microfluidic (MF) chip with integrated commercial PreSens sensors. Xylitol exhibited a significant effect on the pH of saliva in terms of its initial drop, which was the most significant between the 5th and 10th minutes. The effect of xylitol on the amount of oxygen and carbon dioxide in saliva cannot be confirmed. The employed microfluidic platform was shown to be applicable and effective in the analysis of salivary biomarkers relevant to caries development.

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“…Recently proposed microfluidic platforms combine various biocompatible materials and fabrication technologies. (19,20) Commonly used materials for the fabrication of microfluidic chips are polymers such as poly(dimethylsiloxane) (PDMS), PMMA, polyvinyl chloride (PVC), Table 3 Mean values of measurements for non-stimulated human saliva (NSS), stimulated human saliva (SS), NSS with Chlorhexidine (NSS_Ch), SS with Chlorhexidine (SS_Ch), NSS after using Chlorhexidine (NSS_a_Ch), and SS after using Chlorhexidine (SS_a_Ch). different glasses, ceramic materials such as low-temperature co-fired ceramics (LTCCs), and papers in combination, which are subjected to different bonding techniques.…”

Section: Discussionmentioning

confidence: 99%

Microfluidic Approach for Measurements of pH, O2, and CO2 in Saliva

Podunavac¹,

Hinić²,

Kojić³

et al. 2021

Sensors and Materials

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In this paper, we propose a microfluidic approach for measuring pH, dissolved oxygen (O 2), and carbon dioxide (CO 2) in human saliva. The proposed innovative method combines the advantages of a microfluidic approach, i.e., small amounts of samples and reagents and precise control of the experimental conditions, with rapid measurements of significant parameters of saliva. The novel design of a microfluidic chip with integrated commercially available PreSens sensors was used for examining the effect of Chlorhexidine on artificial saliva (AS), stimulated saliva (SS), and non-stimulated saliva (NSS). The measurement results showed that for persons with an initially low saliva pH, the use of Chlorhexidine increased the pH, and afterward, the pH value returned to the initial value or higher. However, measurements of volunteers with initial pH close to neutral showed that Chlorhexidine reduced the pH value, increasing the risk of erosion and demineralization. In conclusion, the proposed methodology showed potential for precise measurements of pH in saliva samples; however, further research is required to examine the influence of the sample collection method on the amounts of O 2 and CO 2 in saliva.

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Optimization of hybrid microfluidic chip fabrication methods for biomedical application

Cited by 13 publications

References 36 publications

Fabrication and Applications of Microfluidic Devices: A Review

Fabrication and Applications of Microfluidic Devices: A Review

Microfluidic Platform for Examination of Effect of Chewing Xylitol Gum on Salivary pH, O2, and CO2

Microfluidic Approach for Measurements of pH, O2, and CO2 in Saliva

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