“…Nevertheless, RSM may be applied to extract from use improved on mechanistic models to when these models are mathematically complex. For example, (Szitkai, Lelkes, Rev, & Fonyo, 2002) applied a regression model based on simulation results of pervaporation membrane networks to optimize ethanol dehydration systems. In the case of spray drying several mechanistic models representing the process dynamic have been proposed (Palencia, Nava, Herman, Rodríguez-Jimenes, & García-Alvarado, 2002;Pérez-Correa, 1995).…”