Optimization of green extraction methods for cinnamic acid and cinnamaldehyde from Cinnamon (Cinnamomum cassia) by response surface methodology

Lee, Sang Chul; Jo, Yunhee; Ameer, Kashif; Kwon, Joong‐Ho

doi:10.1007/s10068-018-0441-y

Cited by 34 publications

(21 citation statements)

References 18 publications

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“…Pulverized Cinnamon quills (10 g) were extracted with pressurized water (200 mL at 0.098 MPa, for 10 min) for the preparation of pressurized water extract (PWE). Quills of Cinnamon (40 g) were extracted by traditional steam distillation (SD) and 10 g were extracted by solvent extraction (SE) using 75% ethanol ( Wong, 2014 ; Lee et al, 2018 ). For the preparation of decoction water extract (DWE), Cinnamon quills (10 g) were boiled with water (200 mL) until the volume was reduced to 1/8.…”

Section: Methodsmentioning

confidence: 99%

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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Background Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. α-amylase and α-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Methods Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique. Results and Discussion Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed in PWE and DWE of SW. Pressured water and decoctions are promising methods for the extraction of antidiabetic constituents from cinnamon. Benzoic acid, cinnamyl alcohol, benzyl alcohol, and 4-Allyl-2,6-dimethoxyphenol were identified as major compounds in SW extracts. These compounds are believed to be responsible for strong enzyme inhibitory activity of the extracts. Conclusions This is the first study to explore the use of pressured and decoctions water to extract anti-diabetic phytochemicals from cinnamon. The extensive metabolite profiling of novel SW and SG extracts and comparison of that with commercially available CC are reported for the first time in this study. The C. zeylanicum, SW accession holds some promise in the management of diabetes.

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Section: Methodsmentioning

confidence: 99%

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Wariyapperuma

Kannangara

Wijayasinghe

et al. 2020

PeerJ

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“…Cinnamaldehyde (CA, Figure 1 ) is the active constituent of cinnamon extract obtained from the bark of Cinnamomum [ 19 , 20 ]. CA has various beneficial effects, such as antibacterial [ 21 ], anti-inflammatory [ 22 ], antioxidative [ 23 ], and antiapoptotic effects [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats

Almoiliqy

Wen

Qaed

et al. 2020

Oxidative Medicine and Cellular Longevity

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The aim of this study was to characterize and reveal the protective effects of cinnamaldehyde (CA) against mesenteric ischemia-reperfusion- (I/R-) induced lung and liver injuries and the related mechanisms. Sprague-Dawley (SPD) rats were pretreated for three days with 10 or 40 mg/kg/d, ig of CA, and then induced with mesenteric ischemia for 1 h and reperfusion for 2 h. The results indicated that pretreatment with 10 or 40 mg/kg of CA attenuated morphological damage in both lung and liver tissues of mesenteric I/R-injured rats. CA pretreatment significantly restored the levels of aspartate transaminase (AST) and alanine transaminase (ALT) in mesenteric I/R-injured liver tissues, indicating the improvement of hepatic function. CA also significantly attenuated the inflammation via reducing myeloperoxidase (MOP) activity and downregulating the expression of inflammation-related proteins, including interleukin-6 (IL-6), interleukin-1β (IL-1β), cyclooxygenase-2 (Cox-2), and tumor necrosis factor receptor type-2 (TNFR-2) in both lung and liver tissues of mesenteric I/R-injured rats. Pretreatment with CA significantly downregulated nuclear factor kappa B- (NF-κB-) related protein expressions (NF-κB p65, NF-κB p50, I kappa B alpha (IK-α), and inhibitor of nuclear factor kappa-B kinase subunit beta (IKKβ)) in both lung and liver tissues of mesenteric I/R-injured rats. CA also significantly downregulated the protein expression of p53 family members, including caspase-3, caspase-9, Bax, and p53, and restored Bcl-2 in both lung and liver tissues of mesenteric I/R-injured rats. CA pretreatment significantly reduced TUNEL-apoptotic cells and significantly inhibited p53 and NF-κB p65 nuclear translocation in both lung and liver tissues of mesenteric I/R-injured rats. CA neither induced pulmonary and hepatic histological alterations nor affected the parameters of inflammation and apoptosis in sham rats. We conclude that CA alleviated mesenteric I/R-induced pulmonary and hepatic injuries via attenuating apoptosis and inflammation through inhibition of NF-κB and p53 pathways in rats, suggesting the potential role of CA in remote organ ischemic injury protection.

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“…Masghati and Ghoreishi (2018) evaluated the supercritical carbon dioxide extraction of cinnamaldehyde and eugenol from cinnamon bark. Lee et al (2018) investigated clean methods to extract cinnamic acid and cinnamaldehyde from Cinnamomum cassia . They optimized microwave‐assisted extraction (MAE), ultrasound‐assisted extraction (UAE) and reflux extraction (RE) parameters.…”

Section: Introductionmentioning

confidence: 99%

Optimization of ohmic heating assisted hydrodistillation of cinnamon and bay leaf essential oil

Tunç

Koca

2020

J Food Process Engineering

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In this work, optimum ohmic heating assisted hydrodistillation (OAHD) conditions for extraction of cinnamon (CEO) and bay leaf (BEO) essential oil were determined by response surface methodology (RSM). OAHD were compared with conventional hydrodistillation (HD). Hydrodistillation time (30–120 min), mass of sample (20–40 g) and voltage gradient (7.5–12.5 V/cm), were varied to maximize essential oil (EO) yield and minimize energy consumption. Optimized OAHD conditions were determined as 119.90 min, 8.83 V/cm and 40 g, and 120 min, 8.53 V/cm and 40 g for CEO and BEO, respectively. EO yields of cinnamon and bay leaves at optimum conditions were found 3.98 ± 0.25% and 1.36 ± 0.14%, respectively. Energy consumptions were found 0.42 ± 0.02 and 0.86 ± 0.09 kWh/g EO for CEO and BEO, respectively. EO yield of OAHD was found to be higher when compared with HD methods for both plant materials. Energy consumptions and emitted CO2 values of OAHD method were significantly (p < 0.05) lower than HD methods. Cinnamaldehyde (CEO) and eucalyptol (BEO) contents of essential oils extracted with OAHD were higher when compared with HD methods. Antioxidant activities of essential oils extracted with different methods were not significantly different. CEO and BEO formed inhibition zones against all tested microorganism strains. Practical Applications Essential oils of cinnamon bark and bay leaf are commonly used for food and pharmaceutical industries and, have important economic value. Conventional hydrodistillation method to extraction essential oils is time consuming, requires more energy and has more CO2 emission rates. Ohmic heating assisted hydrodistillation as a novel technology, is a promising method to extraction of essential oils from different plant materials with lower process times and energy consumption when compared with conventional hydrodistillation. Ohmic heating assisted hydrodistillation method can developed with regard to scale up as a green technology to essential oil production. This work provides a knowledge about the effects of different OAHD process variables on essential oil yield and energy consumption for cinnamon bark and bay leaf essential oils. It is expected that the outcomes of this study will be useful for the designing of large scale ohmic heating assisted hydrodistillation units.

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Optimization of green extraction methods for cinnamic acid and cinnamaldehyde from Cinnamon (Cinnamomum cassia) by response surface methodology

Cited by 34 publications

References 18 publications

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats

Optimization of ohmic heating assisted hydrodistillation of cinnamon and bay leaf essential oil

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