Optimization of Extraction Conditions for Useful Components from Sweet Potato Leaves

Oriental herbal liquor (Yakju) is a type of Korean traditional alcoholic beverage that uses Nuruk and oriental herbs for fermentation. The purpose of this study was to develop cosmetic ingredients using Jubak, which is a by-product of alcoholic fermentation of oriental herbal liquor. To investigate antioxidant, whitening, and anti-aging effects of Jubak, we prepared extract of Jubak and its solvent fractions. Ethyl acetate fraction (KSD E4-3) showed the most prominent free radical [1,1-diphenyl-2-picrylhydrazyl (DPPH)] scavenging activity (SC50: 0.75 mg/mL). KSD E4-3 significantly inhibited in vitro mushroom tyrosinase activity (IC50: 0.82 mg/mL) and reduced the melanin contents in mouse melanoma melanocyte, B16F10 cells. KSD E4-3 down-regulated protein expression of tyrosinase related proteins (TRP)-1, -2, which play key roles in melanogenesis. For anti-aging effects, inhibition of matrix metalloproteinase (MMPs) expression was evaluated using human keratinocyte, HaCaT cells. Treatment of HaCaT cells with KSD E4-3 reduced expression of MMP-1, -2, -9 and inhibited proteolytic activities of MMP-2, -9. These results suggest that KSD E4-3 induces down-regulation of cellular melanogenesis and protects against photoaging induced by UVB-induced damage. Thus KSD E4-3 could potentially be a valuable cosmetic ingredient.

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Optimization of Extraction Conditions for Useful Components from Sweet Potato Leaves

Cited by 8 publications

References 22 publications

Difference of Storability According to the Curing Treatment in Korean Sweetpotato Varieties

Difference of Storability According to the Curing Treatment in Korean Sweetpotato Varieties

Analysis of Physiological Activity and Cytotoxicity of Fermented and Hot Water Extracts Using Residues after Sweet Potato (<i>Ipomoea batatas</i> L.) Harvest

Skin Whitening and Anti-Wrinkle Effects of Extract from Jubak of Oriental Herbal Liquor

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