Optimization of Ethanol Supercritical Fluid Extraction of Medicinal Compounds from St. John's Wort by Central Composite Design

Sage oil extraction and optimization by response surface methodology

“…The calculated F value (10.41) was higher than the tabulated one (3.68) which does not support Null's hypothesis. If the calculated F value is greater than the tabulated one, the result demonstrates the effectiveness of the model and validates the accuracy of the prediction regarding the experimental data (Akalin and Karagoz, 2014;Akalin et al, 2013). The Pareto chart is shown in Fig.…”

“…used for optimization of experimental parameters as it is not only time and reagent saving, but it also provides information about the interactions of parameters (Duarte and Duarte, 2011;Leardi, 2009). Experimental design for process optimization via response surface methodology has been studied by many researchers (Bingol and Kulcu, 2011;Liu et al, 2012;Esfahani et al (2014); Djafarzadeh et al, 2013;Akalin and Karagoz, 2014). Available experimental designs for process optimization include the following: full factorial design (FFD), Plackett-Burman design (PBD), Taguchi design (TD), cental composite design (CCD) and Box-Behnken design (BBD) (Sharif et al, 2014).…”