Optimization of Docetaxel Loading Conditions in Liposomes: proposing potential products for metastatic breast carcinoma chemotherapy

Vakili‐Ghartavol, Roghayyeh; Rezayat, Seyed Mahdi; Faridi‐Majidi, Reza; Sadri, Kayvan; Jaafari, Mahmoud Reza

doi:10.1038/s41598-020-62501-1

Cited by 60 publications

(30 citation statements)

References 54 publications

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“…The self-assembly of diacyl-chain phospholipids in aqueous solutions can form spherical bilayer structures referred to as liposomes. Because of encapsulating an extensive aqueous environment, liposomal structures can load almost any type of hydrophilic molecules ( Lebègue et al, 2015 ; Vakili-Ghartavol et al, 2020 ; Wu et al, 2021 ). Liposome’s internal hydrophilic part can protect loaded drugs from the host body’s destructive factors that ultimately minimize the unwanted side effects.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Nakhaei

Margiana

Bokov

et al. 2021

Front. Bioeng. Biotechnol.

327

163

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Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Nakhaei

Margiana

Bokov

et al. 2021

Front. Bioeng. Biotechnol.

327

163

View full text Add to dashboard Cite

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“…In addition, tumor growth and pulmonary metastasis were inhibited due to enhanced docetaxel induced apoptosis and the reduced metastasis-promoting protein expression [187]. Similar reduction of tumor growth, enhanced uptake, and prevention of metastasis with docetaxel was achieved with other nano-formulations, such as nanoliposomes [188], albumin conjugates [189], Ecoflex ® nanoparticles [190], and human serum albumin nanoparticles [191]. In addition to these formulations, co-encapsulation of docetaxel with other drugs into nano-formulations significantly enhanced the anticancer activity of the compounds in metastatic/multi drug-resistant breast cancer cells.…”

Section: Docetaxelmentioning

confidence: 75%

Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

Gote

Nookala

Bolla

et al. 2021

IJMS

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Breast cancer, specifically metastatic breast, is a leading cause of morbidity and mortality in women. This is mainly due to relapse and reoccurrence of tumor. The primary reason for cancer relapse is the development of multidrug resistance (MDR) hampering the treatment and prognosis. MDR can occur due to a multitude of molecular events, including increased expression of efflux transporters such as P-gp, BCRP, or MRP1; epithelial to mesenchymal transition; and resistance development in breast cancer stem cells. Excessive dose dumping in chemotherapy can cause intrinsic anti-cancer MDR to appear prior to chemotherapy and after the treatment. Hence, novel targeted nanomedicines encapsulating chemotherapeutics and gene therapy products may assist to overcome cancer drug resistance. Targeted nanomedicines offer innovative strategies to overcome the limitations of conventional chemotherapy while permitting enhanced selectivity to cancer cells. Targeted nanotheranostics permit targeted drug release, precise breast cancer diagnosis, and importantly, the ability to overcome MDR. The article discusses various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast cancer stem cells. In addition, the review discusses recent approaches, including combination nanoparticles (NPs), theranostic NPs, and stimuli sensitive or “smart” NPs. Recent innovations in microRNA NPs and personalized medicine NPs are also discussed. Future perspective research for complex targeted and multi-stage responsive nanomedicines for metastatic breast cancer is discussed.

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“…The aggregation of vesicles was not observed. The shape and surface morphology analysis indicated the stability of the prepared liposomes [27].…”

Section: Optimization and Validationmentioning

confidence: 98%

Formulation and Optimization and in Vitro Characterization of Olanzapine Liposome

2021

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Objective: Olanzapine (OZ) is a thioeno benzodiazepine class second-generation or atypical antipsychotic that selectively binds to central dopamine D2 and serotonin (5-HT2c) receptors used for the treatment of schizophrenia and bipolar disorder. The present paper is aimed at developing an optimized liposome-loaded OZ as an approach for brain targeting through the nasal route for effective therapeutic management of schizophrenia. Methods: The OZ liposomes were prepared by the thin-film hydration method. Various independent variable such as phospholipid, cholesterol and sonication time was optimized by using Design-Expert® Software to obtain the dependent variables of entrapment efficiency, vesicle size and zeta potential. The optimized formulation was predicted based on the response obtained by the point prediction method. Results: The entrapment efficiency of the formulation was range between 72.9 and 85.1 %. The average particle size of all the 15 experimental runs lies between the minimum and maximum values of the size 258.33 to 325.32 nm, respectively. The zeta potential ranges from-27.53 to-11.46 mV. The optimized formulation for characterized for its morphology by Transmission Electron Microscopy (TEM). In vitro release studies of OZ-loaded liposomal formulation was carried by dialysis sac method using pH 7.4 phosphate buffer (PBS) as a medium. The maximum release was found to be 98.43±1.2 % up to 24 h. The R2 zero-order kinetics and Korsmeyer-Peppas model was found to be 0.9919 and 0.9664, respectively. The zero-order shows the best-fit model with a highest R2 value exhibiting better correlation and the ‘n’ value was also found to be 0.85; indicating both diffusion-controlled and swelling-controlled drug release that is anomalous transport. Conclusion: The results, clearly states that the prepared formulations justify the parameters and OZ might be a suitable candidate to target the brain through nasal delivery.

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Optimization of Docetaxel Loading Conditions in Liposomes: proposing potential products for metastatic breast carcinoma chemotherapy

Cited by 60 publications

References 54 publications

RETRACTED: Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

RETRACTED: Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol

Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

Formulation and Optimization and in Vitro Characterization of Olanzapine Liposome

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