Optimization of data acquisition for EPR imaging

Ahmad, Rizwan; Clymer, Bradley D.; Deng, Yuanmu; He, Guanglong; Vikram, Deepti S.; Kuppusamy, Periannan; Zweíer, Jay L.

doi:10.1016/j.jmr.2005.12.013

Cited by 14 publications

(9 citation statements)

References 35 publications

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“…Important steps were made in the optimization of image‐acquisition software and image‐reconstruction routines . Implementation of these approaches has been shown to allow reduction in the number of projections, resulting in reduction of total image‐acquisition time and achieving submillimeter resolution in images of isolated rat hearts infused with LiNcBuO suspension and acquired in 264 seconds …”

Section: Discussionmentioning

confidence: 99%

“…33 Important steps were made in the optimization of imageacquisition software and image-reconstruction routines. [36][37][38][39][40][41][42][43] Implementation of these approaches has been shown to allow reduction in the number of projections, resulting in reduction of total image-acquisition time and achieving submillimeter resolution in images of isolated rat hearts infused with LiNcBuO suspension and acquired in 264 seconds. 41,42,44 With regard to hardware development, construction of fast 3D gradients even in combination with high-inductance main magnet allowed significant reduction of CW-EPRI image-acquisition time.…”

Section: Discussionmentioning

confidence: 99%

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Development of a fast‐scan EPR imaging system for highly accelerated free radical imaging

Samouilov

Ahmad

Boslett

et al. 2019

Magnetic Resonance in Med

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Purpose In continuous wave EPR imaging, the acquisition of high‐quality images was previously limited by the requisite long acquisition times of each image projection that was typically greater than 1 second. To accelerate the process of image acquisition facilitating greater numbers of projections and higher image resolution, instrumentation was developed to greatly accelerate the magnetic field scan that is used to obtain each EPR image projection. Methods A low‐inductance solenoidal coil for field scanning was used along with a spherical solenoid air core magnet, and scans were driven by triangular symmetric waves, allowing forward and reverse spectrum acquisition as rapid as 3.8 ms. The uniform distribution of projections was used to optimize the contribution of projections for 3D image reconstruction. Results Using this fast‐scan EPR system, high‐quality EPR images of phantoms and perfused rat hearts were performed using trityl or nanoparticulate LiNcBuO (lithium octa‐n‐butoxy‐substituted naphthalocyanine) probes with fast‐scan EPR imaging at L‐band, achieving spatial resolutions of up to 250 micrometers in 1 minute. Conclusion Fast‐scan EPR imaging can greatly facilitate the efficient and precise mapping of the spatial distribution of free radical and other paramagnetic probes in living systems.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of a fast‐scan EPR imaging system for highly accelerated free radical imaging

Samouilov

Ahmad

Boslett

et al. 2019

Magnetic Resonance in Med

Self Cite

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“…This can be done additively. Analysis of an intermediate image may guide gradient selection for the next projections [38]. The algorithm allows relaxing homogeneity specifications for external magnet and gradient coils.…”

Section: Discussionmentioning

confidence: 99%

New spectral–spatial imaging algorithm for full EPR spectra of multiline nitroxides and pH sensitive trityl radicals

Tseitlin

Biller

Elajaili

et al. 2014

Journal of Magnetic Resonance

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An algorithm is derived and demonstrated that reconstructs an EPR spectral-spatial image from projections with arbitrarily selected gradients. This approach permits imaging wide spectra without the use of the very large sweep widths and gradients that would be required for spectral-spatial imaging with filtered backprojection reconstruction. Each projection is defined as the sum of contributions at the set of locations in the object. At each location gradients shift the spectra in the magnetic field domain, which is equivalent to a phase change in the Fourier-conjugate frequency domain. This permits solution of the problem in the frequency domain. The method was demonstrated for 2D images of phantoms consisting of (i) two tubes containing 14N and 15N nitroxide and (ii) two tubes containing a pH sensitive trityl radical at pH 7.0 and 7.2. In each case spectral slices through the image agree well with the full spectra obtained in the absence of gradient.

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“…Similarly to [31], [39] and [4], we assume that the data is corrupted with an additive independant gaussian white noise denoted n, thus yielding the direct model of spatial EPRI acquisition…”

Section: Direct Modelmentioning

confidence: 99%

Electron paramagnetic resonance image reconstruction with total variation and curvelets regularization

2017

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Spatial electron paramagnetic resonance imaging (EPRI) is a recent method to localize and characterize free radicals in vivo or in vitro, leading to applications in material and biomedical sciences. To improve the quality of the reconstruction obtained by EPRI, a variational method is proposed to inverse the image formation model. It is based on a leastsquare data-fidelity term and the total variation and Besov seminorm for the regularization term. To fully comprehend the Besov seminorm, an implementation using the curvelet transform and the L 1 norm enforcing the sparsity is proposed. It allows our model to reconstruct both image where acquisition information are missing and image with details in textured areas, thus opening possibilities to reduce acquisition times. To implement the minimization problem using the algorithm developed by Chambolle and Pock, a thorough analysis of the direct model is undertaken and the latter is inverted while avoiding the use of filtered backprojection (FBP) and of non-uniform Fourier transform. Numerical experiments are carried out on simulated data, where the proposed model outperforms both visually and quantitatively the classical model using deconvolution and FBP. Improved reconstructions on real data, acquired on an irradiated distal phalanx, were successfully obtained.

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Optimization of data acquisition for EPR imaging

Cited by 14 publications

References 35 publications

Development of a fast‐scan EPR imaging system for highly accelerated free radical imaging

Development of a fast‐scan EPR imaging system for highly accelerated free radical imaging

New spectral–spatial imaging algorithm for full EPR spectra of multiline nitroxides and pH sensitive trityl radicals

Electron paramagnetic resonance image reconstruction with total variation and curvelets regularization

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