Optimization of Cyclotron Production for Radiometal of Zirconium 89

Dabkowski, Adam M.; Paisey, Stephen J.; Talboys, Matthew; Marshall, Christopher

doi:10.12693/aphyspola.127.1479

Cited by 13 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…End of bombardment (EOB) 89 Zr production yields of 48 ± 4 MBq/(μA·hr) were consistent regardless of irradiation current and in good agreement with those observed with our previously used methods described in section I. Additionally, this yield is in agreement with the 49 ± 4 MBq/(μA·hr) measured by Siikanen et al (2014) and significantly higher than that observed by Dabkowskia et al (2015) and Ciarmatori et al (2011) irradiating thinner Y foils at lower proton energies. Thus, the significantly improved proton beam current durability of the Ta-welded Y target increased 89 Zr production capacity by more than threefold.…”

Section: Resultssupporting

confidence: 89%

“…The amount of discoloration to the Y target foil was similar to that of a 15 μA irradiation of Y foil using the previously used 89 Zr production methods described in section I. This irradiation current is also significantly higher than that of Dabkowskia et al (2015) and Ciarmatori et al (2011) used to irradiate thin Y foils and slightly higher than the 45 μA that Siikanen et al (2014) used to irradiate large direct H 2 O-cooled Y foils. Irradiation of Ta-welded Sc and Ta-welded Ho targets with 50 μA protons for 1 – 3 hours yielded visual inspection results identical to that of Ta-welded Y with only slight discoloration and no visible target foil damage observed.…”

Section: Resultssupporting

confidence: 69%

“…As a result, the main factor limiting 89 Zr production is in the design of Y targets that can withstand the hundreds to thousands of watts of thermal power deposited by such a proton beam. In recent years, target designs capable of withstanding 30 – 45 μA of proton irradiation of water- and He-cooled Y foils have been demonstrated by Dabkowskia et al (2015), Ciarmatori et al (2011), and Siikanen et al (2014). However, the former two of these methods utilize thin (0.15 mm) 89 Y target foils limiting the overall 89 Zr production capacity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spot-welding solid targets for high current cyclotron irradiation

Ellison

Valdovinos

Graves

et al. 2016

Applied Radiation and Isotopes

View full text Add to dashboard Cite

Zirconium-89 finds broad application for use in positron emission tomography. Its cyclotron production has been limited by the heat transfer from yttrium targets at high beam currents. A spot welding technique allows a three-fold increase in beam current, without affecting 89Zr quality. An yttrium foil, welded to a jet-cooled tantalum support base accommodates a 50 μA proton beam degraded to 14 MeV. The resulting activity yield of 48 ± 4 MBq/(μA·hr) now extends the outreach of 89Zr for a broader distribution.

show abstract

Section: Resultssupporting

confidence: 89%

Section: Resultssupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spot-welding solid targets for high current cyclotron irradiation

Ellison

Valdovinos

Graves

et al. 2016

Applied Radiation and Isotopes

View full text Add to dashboard Cite

show abstract

“…One of the challenges is the limitation of beam energy, since above the reaction threshold of 13.08 MeV, production of long-lived 88 Zr(T 1/2 = 83 d) occurs via the (p,2n) reaction, which is an impurity inseparable from the final product. Dabkowski et al (Dabkowski et al, 2015 ) used a compact IBA COSTIS target, designed to produce 89 Zr, to show that above the reaction threshold of 11.6 MeV there is a co-production of another contaminant 88 Y (T 1/2 = 107 d) via 89 Y(p,pn) 88 Y. The yttrium atoms must be separated in the following chemistry process minimizing this amount.…”

Section: Developments In Radionuclide Productionmentioning

confidence: 99%

Production of novel diagnostic radionuclides in small medical cyclotrons

Synowiecki

Perk

Nijsen

2018

EJNMMI radiopharm. chem.

View full text Add to dashboard Cite

The global network of cyclotrons has expanded rapidly over the last decade. The bulk of its industrial potential is composed of small medical cyclotrons with a proton energy below 20 MeV for radionuclides production. This review focuses on the recent developments of novel medical radionuclides produced by cyclotrons in the energy range of 3 MeV to 20 MeV. The production of the following medical radionuclides will be described based on available literature sources: Tc-99 m, I-123, I-124, Zr-89, Cu-64, Ga-67, Ga-68, In-111, Y-86 and Sc-44. Remarkable developments in the production process have been observed in only some cases. More research is needed to make novel radionuclide cyclotron production available for the medical industry.

show abstract

“…The irradiation data are presented in Table 3. It is worth noting that the Y foil targets (thickness from 0.15 to 1 mm) commonly used by different groups to produce 89 Zr [19,38,[50][51][52][53] can sustain, without any critical damage, only currents under 40 µA. Instead, the targets realized in this work have supported up to 1 kW/cm 2 heat power density, corresponding to relatively higher current values, which can increase the 89 Zr radioisotope production yields.…”

Section: Cyclotron Testmentioning

confidence: 98%

Medical Cyclotron Solid Target Preparation by Ultrathick Film Magnetron Sputtering Deposition

et al. 2019

View full text Add to dashboard Cite

Magnetron sputtering is proposed here as an innovative method for the deposition of a material layer onto an appropriate backing plate for cyclotron solid targets aimed at medical radioisotopes production. In this study, a method to deposit thick, high-density, high-thickness-uniformity, and stress-free films of high adherence to the backing was developed by optimizing the fundamental deposition parameters: sputtering gas pressure, substrate temperature, and using a multilayer deposition mode, as well. This method was proposed to realize Mo-100 and Y-nat solid targets for biomedical cyclotron production of Tc-99m and Zr-89 radionuclides, respectively. The combination of all three optimized sputtering parameters (i.e., 1.63 × 10−2 mbar Ar pressure, 500 °C substrate temperature, and the multilayer mode) allowed us to achieve deposition thickness as high as 100 µm for Mo targets. The 50/70-µm-thick Y targets were instead realized by optimizing the sputtering pressure only (1.36 × 10−2 mbar Ar pressure), without making use of additional substrate heating. These optimized deposition parameters allowed for the production of targets by using different backing materials (e.g., Mo onto copper, sapphire, and synthetic diamond; and Y onto a niobium backing). All target types tested were able to sustain a power density as high as 1 kW/cm2 provided by the proton beam of medical cyclotrons (15.6 MeV for Mo targets and 12.7 MeV for Y targets at up to a 70-µA proton beam current). Both short- and long-time irradiation tests, closer to the real production, have been realized.

show abstract

Optimization of Cyclotron Production for Radiometal of Zirconium 89

Cited by 13 publications

References 10 publications

Spot-welding solid targets for high current cyclotron irradiation

Spot-welding solid targets for high current cyclotron irradiation

Production of novel diagnostic radionuclides in small medical cyclotrons

Medical Cyclotron Solid Target Preparation by Ultrathick Film Magnetron Sputtering Deposition

Contact Info

Product

Resources

About