Optimization of culture medium for yellow pigments production with Monascus anka mutant using response surface methodology

Zhou, Bo; Wang, Jufang; Pu, Yuewu; Zhu, Ming‐Jun; Liu, Shiming; Song, Liang

doi:10.1007/s00217-008-1002-z

Cited by 49 publications

(36 citation statements)

References 34 publications

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“…Zhou et al also screened a Monascus anka mutant by physical and chemical combination mutagenesis (Zhou et al 2008). High color hue of yellow Monascus pigments is achieved by further optimization of culture medium (Zhou et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Zhang

et al. 2014

Appl Microbiol Biotechnol

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Monascus species can produce various secondary metabolites of polyketide structure. In the current study, it is found that an interesting phenomenon, i.e., submerged culture of Monascus species in an aqueous solution majorly accumulated intracellular orange Monascus pigments exhibiting one peak at 470 nm with absorbance of 32 OD while extractive fermentation in a nonionic surfactant micelle aqueous solution produced extracellular and intracellular yellow Monascus pigments exhibiting one peak at 410 nm with absorbance 30 OD and 12 OD, respectively. The spectrum profiles of both intracellular and extracellular Monascus pigments were affected by surfactant loading, extractive fermentation time, and surfactant adding time. Meanwhile, the instability of orange Monascus pigments in the extracellular nonionic surfactant micelle aqueous solution was also confirmed experimentally. The mechanism behind this phenomenon is attributed to the export of intracellular yellow Monascus pigments into its broth by extractive fermentation. The transferring of intracellular yellow Monascus pigments into its broth blocks yellow Monascus pigments from further enzymatic conversion or eliminates the feedback inhibition of yellow Monascus pigments based on the biosynthetic pathway of Monascus pigments.

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Section: Introductionmentioning

confidence: 99%

Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Zhang

et al. 2014

Appl Microbiol Biotechnol

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“…The red pigment includes monascorubramine and rubropunctamine that are the nitrogen analogues of the orange pigment. The yellow pigment includes monascin and ankaflavin [5]. Among these pigments, the red pigment (monascorubramine and rubropunctamine) is of high demand, especially for its use in meat products to substitute nitrites [2].…”

Section: Introductionmentioning

confidence: 99%

Purification and characterization of a new red pigment from Monascus purpureus in submerged fermentation

Mukherjee

Singh

2011

Process Biochemistry

106

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“…Nevertheless, appropriate species should satisfy some criteria: i) ability to use a variety of C and N sources, ii) tolerance to growth conditions (e.g. pH, temperature, nutrient concentration), iii) providing expected color at reasonable yield, iv) non-toxic and non-pathogenic product, and v) simple extraction of pigment from cell biomass if not excreted (Brunke et al, 2010;Hailei, Ping, Yufeng, Zhifang, & Gang, 2012;Zhou et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Bacteria belonging to the extremely versatile genus Arthrobacter as novel source of natural pigments with extended hue range

Sutthiwong

Fouillaud²,

Valla

et al. 2014

Food Research International

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Optimization of culture medium for yellow pigments production with Monascus anka mutant using response surface methodology

Cited by 49 publications

References 34 publications

Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Accumulation of yellow Monascus pigments by extractive fermentation in nonionic surfactant micelle aqueous solution

Purification and characterization of a new red pigment from Monascus purpureus in submerged fermentation

Bacteria belonging to the extremely versatile genus Arthrobacter as novel source of natural pigments with extended hue range

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