Optimization of cisplatin for the treatment of hormone dependent tumoral diseases

Synthesis, spectral, antitumor, antioxidant and antimicrobial studies on Cu(II), Ni(II) and Co(II) complexes of 4-[(1H-Benzoimidazol-2-ylimino)-methyl]-benzene-1,3-diol

“…The clinical success of platinum-based drugs as anticancer agents is severely affected by the serious side effects, toxicity and acquired drug resistance [4][5][6]. These drawbacks drive inorganic chemists to develop innovative strategies for the preparation of more effective, less toxic, target specific and preferably non-covalently bound anticancer drugs.…”

Synthesis, Characterization, and Cytotoxic Activity of Novel Platinum(II) Complexes Derived from N‐Benzyl‐Ethylenediamine and Oxalate

“…Schonenberger and co-authors have reported upon the ability of ethylenediamine derivatives and their Pt(II) complexes to bind to estrogen receptors, being active against hormone-dependent mammary carcinoma resistant to cisplatin (25)(26)(27)(28)(29).…”

DNA binding, oxidative DNA cleavage, cytotoxicity, and apoptosis-inducing activity of copper(II) complexes with 1,4-tpbd (N,N,N′,N′-tetrakis(2-yridylmethyl)benzene-1,4-diamine) ligand

“…As we are known, Cisplatin and its derivatives are the most widely used metal-based drug for cancer therapy, but their use is restricted by serious side effects, general toxicity, and acquired drug resistance [8][9][10][11][12][13][14]. These drawbacks drive inorganic chemists to develop innovative strategies for the preparation of more effective, less toxic, target specific, and preferably noncovalently bound anticancer drugs.…”