Optimization of chitosan-polyvinylalcohol electrospinning process by response surface methodology (RSM)

Gholipour, Alireza; Bahrami, S. Hajir; Nouri, Marjan

doi:10.1515/epoly.2010.10.1.361

Cited by 15 publications

(17 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As presented by researchers at dilute acetic acid (2%) an increase of applied voltage results in a reduction of fibre diameter while in the present work it was observed that concentrated acetic acid (90%) lead to the opposite trend (Figure ). With increasing the acetic acid concentration the solution surface tension reduced significantly.…”

Section: Resultssupporting

confidence: 54%

Fabrication of high performance chitosan/polyvinyl alcohol nanofibrous mat with controlled morphology and optimised diameter

et al. 2014

View full text Add to dashboard Cite

The main aim of the present study is to fabricate a high performance chitosan (CS)/polyvinyl alcohol (PVA) electrospun nanofibrous mat having a high content of CS, a desirable morphology (defect‐free structure) and a superfine diameter (approx. 100 nm). As electrospinning of constructions containing CS is known as a complex process, it is necessary to employ systematic control and optimisation of processes. In this regard, the controlling and optimisation of the processes were followed by two subsequent stages. In the first stage, morphology controlling parameters were investigated with respect to CS/PVA solution characteristics including CS concentration, solvent concentration and the content of the partner polymer (PVA). In the second stage, in order to attain the finest possible diameter, process modelling was carried out in terms of processing parameters (applied voltage, nozzle‐collector distance and feed rate) by using response surface methodology (RSM). According to the experimental results of the first stage, the best morphological structure containing the highest content of CS was obtained under 3% (w/v) of CS, concentrated acetic acid (90%) and 20% weight ratio of PVA. The significance of the applied model was confirmed by statistical approaches and the effect of the selected parameters on the diameter was studied. Experimentally, the finest diameter of 104 ± 18 nm was obtained under optimised processing parameters determined from the RSM technique. The experimental value of the nanofibre diameter was in close agreement with the predicted value in which the prediction error of the model was only 1.92% confirming the high reliability of the applied model.

show abstract

Section: Resultssupporting

confidence: 54%

Fabrication of high performance chitosan/polyvinyl alcohol nanofibrous mat with controlled morphology and optimised diameter

et al. 2014

View full text Add to dashboard Cite

show abstract

“…These easily visible differences could be produced by sudden changes in chitosan chain structures during the processing. An interesting explanation was given by Gholipour et al [24]. They observed that increasing the chitosan content produces brittle fibers; also high viscosity of pure chitosan causes severe problems such that fibers cannot even be electrospun.…”

Section: Methodsmentioning

confidence: 99%

Natural-Synthetic Hybrid Polymers Developed via Electrospinning: The Effect of PET in Chitosan/Starch System

Espíndola-Gonzalez

Martínez-Hernández

Fernández-Escobar

et al. 2011

IJMS

View full text Add to dashboard Cite

Chitosan is an amino polysaccharide found in nature, which is biodegradable, nontoxic and biocompatible. It has versatile features and can be used in a variety of applications including films, packaging, and also in medical surgery. Recently a possibility to diversify chitosan properties has emerged by combining it with synthetic materials to produce novel natural-synthetic hybrid polymers. We have studied structural and thermophysical properties of chitosan + starch + poly(ethylene terephthalate) (Ch + S + PET) fibers developed via electrospinning. Properties of these hybrids polymers are compared with extant chitosan containing hybrids synthesized by electrospinning. Molecular interactions and orientation in the fibers are analyzed by infrared and Raman spectroscopies respectively, morphology by scanning electron microscopy and thermophysical properties by thermogravimetric analysis and differential scanning calorimetry. Addition of PET to Ch + S systems results in improved thermal stability at elevated temperatures.

show abstract

“…Chitosan/PVA nanofibers have been fabricated successfully by electrospinning of chitosan in the presence of PVA using 2 wt% acetic acid as a solvent at various weight ratios between the polymer partners . The chitosan/PVA fibrous mats manifest a good antibacterial activity against the Gram‐negative bacteria Pseudomonas aeruginosa and are non‐toxic towards rat fibroblast L929 cells.…”

Section: Chitosan‐containing Nanofibrous Materials With Antibacterialmentioning

confidence: 99%

Electrospun Antibacterial Chitosan-Based Fibers

2013

View full text Add to dashboard Cite

Chitosan is non-toxic, biocompatible, and biodegradable polysaccharide from renewable resources, known to have inherent antibacterial activity, which is mainly due to its polycationic nature. The combining of all assets of chitosan and its derivatives with the unique properties of electrospun nanofibrous materials is a powerful strategy to prepare new materials that can find variety of biomedical applications. In this article the most recent studies on different approaches for preparation of antibacterial fibrous materials from chitosan and its derivatives such as electrospinning, coating, and electrospinning-electrospraying, loading of drugs or bioactive nanoparticles are summarized.

show abstract

Optimization of chitosan-polyvinylalcohol electrospinning process by response surface methodology (RSM)

Cited by 15 publications

References 9 publications

Fabrication of high performance chitosan/polyvinyl alcohol nanofibrous mat with controlled morphology and optimised diameter

Fabrication of high performance chitosan/polyvinyl alcohol nanofibrous mat with controlled morphology and optimised diameter

Natural-Synthetic Hybrid Polymers Developed via Electrospinning: The Effect of PET in Chitosan/Starch System

Electrospun Antibacterial Chitosan-Based Fibers

Contact Info

Product

Resources

About