Large amounts of agricultural waste are left unutilized in Nigeria, resulting in detrimental environmental consequences. Particleboard made from such trash would help to reduce deforestation and have a good impact on the environment. The characteristics of particleboard made from corn cob (CC) and sugarcane bagasse (SB) with cassava starch and urea formaldehyde as separate binders were compared in this study. CC and SB mix proportions of 90:10, 70:30, and 50:50 percent (by volume) were used to make three layers of medium density particleboard. Manual mixing and blending of 25% and 10% by volume of the different binders and water respectively was done. The mixtures were compressed for 1 hour at 100 °C and 342 kg/m2. The ASTM D. 1037-12 (2020) and EN 312 (2010) standards were used to evaluate the particleboard. However, particleboard produced from 90 % CC and 10 % SB with cassava starch binder had the greatest modulus of elasticity (MOE) of 444.65 N/mm2 and modulus of rapture (MOR) of 10.59 N/mm2. The MOR and MOE data from this investigation allowed researchers to draw the conclusion that while the mechanical qualities of the panels improved as the fraction of CC particles increased, the panels' physical characteristics remained subpar.