Optimization of antimicrobial prescription in the hospital

Vieceli, Tarsila; Rello, Jordi

doi:10.1016/j.ejim.2022.08.035

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…The preferred means of improving antimicrobial stewardship include a comprehensive program that incorporates collaboration among specialists and support staff within an institution. In this context, the direct involvement of all prescribers in ASPs can be highly impactful [ 90 ].…”

Section: Methodsmentioning

confidence: 99%

Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

Sartelli,

Barie,

Coccolini

et al. 2023

World J Emerg Surg

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Antibiotics are recognized widely for their benefits when used appropriately. However, they are often used inappropriately despite the importance of responsible use within good clinical practice. Effective antibiotic treatment is an essential component of universal healthcare, and it is a global responsibility to ensure appropriate use. Currently, pharmaceutical companies have little incentive to develop new antibiotics due to scientific, regulatory, and financial barriers, further emphasizing the importance of appropriate antibiotic use. To address this issue, the Global Alliance for Infections in Surgery established an international multidisciplinary task force of 295 experts from 115 countries with different backgrounds. The task force developed a position statement called WARNING (Worldwide Antimicrobial Resistance National/International Network Group) aimed at raising awareness of antimicrobial resistance and improving antibiotic prescribing practices worldwide. The statement outlined is 10 axioms, or “golden rules,” for the appropriate use of antibiotics that all healthcare workers should consistently adhere in clinical practice.

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Section: Methodsmentioning

confidence: 99%

Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

Sartelli,

Barie,

Coccolini

et al. 2023

World J Emerg Surg

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“…A comprehensive programme involving collaboration between professionals and support staff in the facility is the preferred means of improving antimicrobial stewardship. Direct involvement of all prescribers in ASP can be of great importance [90].…”

Section: український журнал клінічної хірургіїmentioning

confidence: 99%

Ten golden rules for optimal antibiotic use in hospitals: based on the publication statement of the International Network Group of the World Antimicrobial Resistance

Kryvoruchko,

Sartelli

2024

UJCS

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“…The emergence of resistance in pathogenic bacteria is a serious public health problem; still, prescribers misuse and over-use antibiotics [ 25 , 33 , 34 , 35 , 36 ]. It is difficult to change prescription behaviour; interventions such as antibiotic education, local clinical practice guidelines, audit and feedback, or antibiotic restriction have been shown to decrease antibiotic consumption in patients with febrile neutropenia without impacting the length of stay or mortality [ 27 , 28 , 29 , 30 ], and should be attempted.…”

Section: Ams Strategies To Optimize Antibiotic Therapymentioning

confidence: 99%

“…Standard dosage regimens are based on healthy volunteers and do not take into account patient/pathogen characteristics. Underdosing of antibiotics is frequent in patients with sepsis, and is associated with treatment failures and worse outcomes [ 35 , 97 ]. Patients with severe infections are at higher risk of suboptimal antibiotic dose.…”

Section: Ams Strategies To Optimize Antibiotic Therapymentioning

confidence: 99%

Antimicrobial Stewardship on Patients with Neutropenia: A Narrative Review Commissioned by Microorganisms

et al. 2023

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The emergence of antibiotic resistance poses a global health threat. High-risk patients such as those with neutropenia are particularly vulnerable to opportunistic infections, sepsis, and multidrug-resistant infections, and clinical outcomes remain the primary concern. Antimicrobial stewardship (AMS) programs should mainly focus on optimizing antibiotic use, decreasing adverse effects, and improving patient outcomes. There is a limited number of published studies assessing the impact of AMS programs on patients with neutropenia, where early appropriate antibiotic choice can be the difference between life and death. This narrative review updates the current advances in strategies of AMS for bacterial infections among high-risk patients with neutropenia. Diagnosis, drug, dose, duration, and de-escalation (5D) are the core variables among AMS strategies. Altered volumes of distribution can make standard dose regimens inadequate, and developing skills towards a personalized approach represents a major advance in therapy. Intensivists should partner antibiotic stewardship programs to improve patient care. Assembling multidisciplinary teams with trained and dedicated professionals for AMS is a priority.

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Optimization of antimicrobial prescription in the hospital

Cited by 12 publications

References 45 publications

Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action

Ten golden rules for optimal antibiotic use in hospitals: based on the publication statement of the International Network Group of the World Antimicrobial Resistance

Antimicrobial Stewardship on Patients with Neutropenia: A Narrative Review Commissioned by Microorganisms

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