Optimization of Analytical Methods Using Response Surface Methodology - Part II: Mixture Variables

Novaes, Cléber Galvão; Yamaki, Regina Terumi; Paula, Vanderlúcia Fonseca de; Nascimento, Baraquízio Braga do; Barreto, Jeferson Alves; Valasques, Gisseli Souza; Bezerra, Marcos Almeida

doi:10.21577/1984-6835.20180030

Cited by 11 publications

(7 citation statements)

References 6 publications

(7 reference statements)

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“…The analytical response obtained is dependent on the proportions of each component. 24 In this study, a mixture design with restrictions was applied, involving three variables: ultrapure water volume (X 1 ), volume of 30% peroxide (X 2 ) and volume of 4.0 mol L −1 nitric acid (X 3 ). Four different approaches were used to evaluate the digestion procedure, at a confidence level of 95%: (i) D; (ii) MR; (iii) RCC and (iv) residual acidity.…”

Section: Resultsmentioning

confidence: 99%

“…22,23 These optimization techniques are particularly used in analytical chemistry in order to make a procedure more efficient and sensitive. 24 The purpose of this research was to develop a digestion procedure through the application of mixture design to optimize the components of a mixture (water, hydrogen peroxide and diluted nitric acid) for the digestion of different fruit tissues (seed, peel and pulp) of Casearia fasciculata. The design was evaluated through two general responses (desirability and multiple response) for ten elements, residual acidity and residual carbon content.…”

Section: Introductionmentioning

confidence: 99%

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Application of Mixture Design Using Diluted Acid for Extraction of Inorganic Components in Fruits of Casearia fasciculata and Determination by ICP OES: Evaluation by PCA and HCA

Romão¹,

Novais²,

Assis³

et al. 2020

J. Braz. Chem. Soc.

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This study is the first to propose the simultaneous quantification of 10 elements in fruits of Casearia fasciculata by inductively coupled plasma optical emission spectrometry (ICP OES). A method of digestion using dilute nitric acid was optimized by mixture design for extraction of elements in the seed, peel, and pulp of Casearia fasciculata cultivated in the Bahia State, Northeastern Brazil. Four different approaches were used to evaluate the digestion procedure ((i) desirability; (ii) multiple response; (iii) residual carbon content and (iv) residual acidity). The accuracy of the method of digestion was applied for the extraction of the studied elements in two certified reference materials (RM-Agro E1001a Brachiaria brizantha and NIST 1515 apple leaves). The limits of quantification of the method (µg g −1 ) were: Cr, 0.42; Cu, 0.69; Fe, 1.5; Mn, 0.14; Zn, 1.8; Ca, 29.0; K, 3.5; Mg, 1.9; P, 6.4; and S, 17. Two multivariate tools, principal component analysis (PCA) and hierarchical cluster analysis (HCA), were efficient in the formation of groups, corresponding to the fruit parts. Thus, the peel and seed of Casearia fasciculata present potential to be used as mineral supplements in human nutrition.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of Mixture Design Using Diluted Acid for Extraction of Inorganic Components in Fruits of Casearia fasciculata and Determination by ICP OES: Evaluation by PCA and HCA

Romão¹,

Novais²,

Assis³

et al. 2020

J. Braz. Chem. Soc.

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“…73,74 A quimiometria pode ser dividida em quatro grandes vertentes: (i) planejamento fatorial e metodologia de superfície de respostas; (ii) análise exploratória de dados químicos; (iii) modelos de classificação; e (iv) calibração multivariada. [75][76][77][78][79] Todas as vertentes referidas são amplamente empregadas no desenvolvimento de métodos analíticos por LIBS.…”

Section: Libs E Quimiometriaunclassified

Laser Induced-Breakdown Spectroscopy (Libs): Histórico, Fundamentos, Aplicações E Potencialidades

Costa¹,

Augusto²,

Castro³

et al. 2019

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This review attempts to present a broad view of the technique laser-induced breakdown spectroscopy (LIBS), since its origin, fundamentals, sample preparation strategies, use of chemometric tools for data processing, the advantages and limitations with regard to qualitative and quantitative analysis, aplications and future trends as an analytical technique that is in consolidation in analytical chemistry. LIBS is a rapid and versatile, which is able of providing qualitative and quantitative analytical information for practically any sample, in a virtually non-destructive way, without any substantial sample preparation. The instrumentation is simple, robust, compact, and enables remote analysis. The advancement of the LIBS applications in the areas of agriculture, environmental, food, biological/pharmaceutical, forensic, metallurgy and electronic waste were discussed in detail in this review. We consider that this review will be an important tool concerning dissemination of the LIBS, mainly for audience of undergraduate courses, and disciplines related to instrumental analysis.

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“…[20][21][22] The planning application can determine or quantify the process parameters influence on the desired responses, providing reliable results and consistent statistical analyzes. 23 In addition, it is possible to optimize the process by reducing the time and cost, generating greater productivity when selecting the best reaction conditions.…”

Section: Introductionmentioning

confidence: 99%

Effect of injection parameters on the thermal, mechanical and thermomechanical properties of polycaprolactone (PCL)

Luna

Siqueira

Ferreira

et al. 2021

Journal of Elastomers & Plastics

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In this work, an experimental design was applied in the injection molding process of polycaprolactone (PCL), aiming to evaluate the mechanical properties (impact strength, tensile strength and Shore D Hardness), thermal (differential scanning calorimetry (DSC)) and thermomechanical (heat deflection temperature (HDT)), in PCL injected specimens. A type 2n planning was applied, with n = 3 and central point, having the input factors: processing temperature profile, mold temperature and injection flow. The results showed that the DSC curves presented a complex mechanism during crystallization, suggesting that depending on the processing conditions a high degree of crystallinity can be obtained. When using a higher processing temperature and a higher injection flow, there is an increase in the mass of the PCL parts. The impact strength is more expressive when a higher injection flow and a lower processing temperature are applied, reaching values around 260 J/m. The mold temperature impairs the elongation at the break of the PCL, while the elastic modulus was governed by the degree of crystallinity. A deleterious effect on HDT was observed with increased injection flow, suggesting that this parameter negatively affects thermomechanical resistance. The use of experimental design in the processing of PCL is important, since it is possible to optimize properties with the ideal conditions of injection molding.

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Optimization of Analytical Methods Using Response Surface Methodology - Part II: Mixture Variables

Cited by 11 publications

References 6 publications

Application of Mixture Design Using Diluted Acid for Extraction of Inorganic Components in Fruits of Casearia fasciculata and Determination by ICP OES: Evaluation by PCA and HCA

Application of Mixture Design Using Diluted Acid for Extraction of Inorganic Components in Fruits of Casearia fasciculata and Determination by ICP OES: Evaluation by PCA and HCA

Laser Induced-Breakdown Spectroscopy (Libs): Histórico, Fundamentos, Aplicações E Potencialidades

Effect of injection parameters on the thermal, mechanical and thermomechanical properties of polycaprolactone (PCL)

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