Optimization of an autologous human skin model under GMP guidelines

Fernández-González, A.; Lizana-Moreno, A.; Ruiz-Garcia, A.; Guerrero-Calvo, J; Espinosa, Olga; Fernández, N.; Ordóñez-Luque, A.; Sierra-Sánchez, Álvaro; Arias‐Santiago, Salvador

doi:10.1016/j.jcyt.2017.02.338

Cited by 1 publication

(3 citation statements)

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“…An encouraging example of this tissues and organs clinical translation is being carried out in Andalucia, where fourteen severely burned patients have received an autologous Bioengineered Artificial Skin Substitute (BASS) transplantation [4,5]. The results showed an 80% survivance rate and clinical, homeostatic and histological positive findings [6].…”

Section: Advances In Tissue Engineeringmentioning

confidence: 99%

“…The primordial utility of these skin models has been grafting. There are commercial artificial skin substitutes [25] and autologous BASS manufactured under GMP conditions [4,7] to treat patients with burns. Furthermore, these BASS are also being used to analyze and take measurements of the physiological features of human skin [25].…”

Section: Applicationsmentioning

confidence: 99%

“…Biomedicines 2020, 8, x FOR PEER REVIEW 4 of 28 24 h before. The skin substitute is maintained in culture for approximately 1-2 weeks, and after that, it undergoes a pressure dehydration process in which it acquires its final thickness when water is removed [4,22]. This is a successful example within the multitude of procedures described for manufacturing artificial human skin.…”

Section: Applicationsmentioning

confidence: 99%

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Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis

et al. 2020

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This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS) applications. At the first moment, they were created as an attempt to replace native skin grafts transplantation. Nowadays, these in vitro models have been increasing and widening their application areas, becoming important tools for research. This study is focus on the ability to design in vitro BASS which have been demonstrated to be appropriate to develop new products in the cosmetic and pharmacology industry. Allowing to go deeper into the skin disease research, and to analyze the effects provoked by environmental stressful agents. The importance of BASS to replace animal experimentation is also highlighted. Furthermore, the BASS validation parameters approved by the OECD (Organisation for Economic Co-operation and Development) are also analyzed. This report presents an overview of the skin models applicable to skin research along with their design methods. Finally, the potential and limitations of the currently available BASS to supply the demands for disease modeling and pharmaceutical screening are discussed.

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Section: Advances In Tissue Engineeringmentioning

confidence: 99%