Optimization of a solid phase extraction and hydrophilic interaction liquid chromatography–tandem mass spectrometry method for the determination of metformin in dietary supplements and herbal medicines

Wu, Xueyuan; Zhu, Baolin; Lü, Lin; Huang, Weixiong; Pang, Dai‐Wen

doi:10.1016/j.foodchem.2012.01.005

Cited by 40 publications

(14 citation statements)

References 29 publications

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“…When comparing our method with previously published methods for analysis of anti‐diabetic compounds in botanical dietary supplements, we note that our method provides adequate selectivity, sensitivity, accuracy, and precision and simultaneously analyzes a wider range of target compounds including anti‐diabetic, anti‐obesity, and cholesterol‐lowering compounds. However, the instrument was not run in full scan mode and therefore, would not likely detect any adulterants other than the 19 targeted analytes.…”

Section: Resultsmentioning

confidence: 99%

“…When comparing our method with previously published methods for analysis of anti-diabetic compounds in botanical dietary supplements, 10,[12][13][14]16,18,33 we note that our method provides adequate selectivity, sensitivity, accuracy, and precision and simultaneously ana- able for studies such as those described in this paper. 34 3.3 | Dietary supplements…”

Section: Stabilitymentioning

confidence: 91%

“…[7][8][9] The presence of synthetic anti-diabetic drugs (eg, metformin, phenformin, rosiglitazone, gliclazide, glibenclamide, glimepiride) in Chinese proprietary medicines, anti-diabetic herbal medicines, and products identified as dietary supplements and labeled for blood sugar management is well documented. [7][8][9][10][11][12][13][14][15][16][17][18][19] A variety of analytical methods has been developed for detecting synthetic drugs in traditional herbal medicines and these reports are usually accompanied by analyses of proprietary medicines or dietary supplements sold for blood sugar management. 7,8,[10][11][12][13][14][15][16][17][18][19][20] [Table S1 (Supporting Information)].…”

Section: Introductionmentioning

confidence: 99%

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Validation of an LC–MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management

Pawar

Grundel

2017

Drug Testing and Analysis

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We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to detect and quantitate 14 anti-diabetic, 2 anti-obesity, and 3 cholesterol-lowering drugs in botanical dietary supplements marketed for blood sugar management. Many botanical dietary supplements which carry label statements related to blood sugar management are available over the Internet. Potential adulteration of such dietary supplements with anti-diabetic and other prescription drugs, some of which have been removed from the market due to adverse events, is of concern. No significant matrix effects were observed and mean recoveries of all 19 analytes from a single product matrix were 88 to 113% at spiking concentrations from 500 to 2000 μg/g. Mean recoveries of metformin, phenformin, and sibutramine from matrices prepared from multiple product composites ranged from 93 to 115% at a spiking concentration of 100 μg/g. The relative standard deviations (RSD) (%) of intra-day analyses ranged from 0.2 to 13 for all recovery studies. Eighty dietary supplements obtained in the USA and carrying label statements related to blood sugar management were analyzed using this method and none were found to be adulterated with the above 19 drugs. Two products obtained outside of the USA and known to be adulterated were also analyzed by this method and found to contain phenformin, glibenclamide, and sibutramine. This method provided satisfactory selectivity, linearity, accuracy, precision, and sensitivity for rapid determination of 19 drugs and has broad applicability for the analysis of dietary supplements for possible adulteration with these compounds.

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Section: Resultsmentioning

confidence: 99%

Section: Stabilitymentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Validation of an LC–MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management

Pawar

Grundel

2017

Drug Testing and Analysis

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“…LC-MS has become a key method in identifying compounds in HMPs and other botanical products, as it is capable of providing data on both the quantities and structures. This method was used for the detection of an extremely polar hypoglycemic drug, metformin, found in HMPs [54]. This concluded with a more separated and pure sample of metformin from matrix interferences.…”

Section: Mass Spectrometry-based Techniquesmentioning

confidence: 99%

Chemical Adulterants in Herbal Medicinal Products: A Review

et al. 2016

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Many herbal medicinal products have been found to contain synthetic prescription drugs as chemical adulterants. This has become evident by the number of toxicity cases and adverse reactions reported in which casualties were reported via analytical techniques that detected the presence of chemical adulterants in them, which could be responsible for their toxicity. The adulteration of herbal medicinal products with synthetic drugs continues to be a serious problem for regulatory agencies. This review provides up to date information on cases of toxicity, major chemical adulterants in herbal medicinal products, and current analytical techniques used for their detection.

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“…This method was used for the detection of an extremely polar hypoglycemic drug, metformin, found in HMPs [54]. This concluded with a more separated and pure sample of metformin from matrix interferences.…”

Section: Mass Spectrometry-based Techniquesmentioning

confidence: 99%

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2016

Planta Med

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Optimization of a solid phase extraction and hydrophilic interaction liquid chromatography–tandem mass spectrometry method for the determination of metformin in dietary supplements and herbal medicines

Cited by 40 publications

References 29 publications

Validation of an LC–MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management

Validation of an LC–MS/MS method for analysis of anti‐diabetic drugs in botanical dietary supplements labeled for blood sugar management

Chemical Adulterants in Herbal Medicinal Products: A Review

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