Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients

Nazzal, Sami; Nutan, Mohammad T. H.; Palamakula, Anitha; Shah, Rakhi B.; Zaghloul, Abdel-Azim; Khan, Mansoor A.

doi:10.1016/s0378-5173(02)00130-8

Cited by 114 publications

(50 citation statements)

References 23 publications

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“…The faster drug release from SNEDDS is attributed due to spontaneous formation of nanoemulsion due to low surface free energy at oil-water interface, which causes immediate solubilization of drug in dissolution medium. During emulsification with water, oil, surfactant, and cosurfactant effectively swells and decreases; the globule size leads to decrease in surface area and surface free energy, thus eventually increases the drug release rate (23).…”

Section: Comparative In Vitro Drug Release Studiesmentioning

confidence: 99%

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Development, Optimization, and Characterization of Solid Self-Nanoemulsifying Drug Delivery Systems of Valsartan Using Porous Carriers

et al. 2012

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Abstract. The present studies entail formulation development of novel solid self-nanoemulsifying drug delivery systems (S-SNEDDS) of valsartan with improved oral bioavailability, and evaluation of their in vitro and in vivo performance. Preliminary solubility studies were carried out and pseudoternary phase diagrams were constructed using blends of oil (Capmul MCM), surfactant (Labrasol), and cosurfactant (Tween 20). The SNEDDS were systematically optimized by response surface methodology employing 3 3-Box-Behnken design. The prepared SNEDDS were characterized for viscocity, refractive index, globule size, zeta potential, and TEM. Optimized liquid SNEDDS were formulated into free flowing granules by adsorption on the porous carriers like Aerosil 200, Sylysia (350, 550, and 730) and Neusilin US2, and compressed into tablets. In vitro dissolution studies of S-SNEDDS revealed 3-3.5-fold increased in dissolution rate of the drug due to enhanced solubility. In vivo pharmacodynamic studies in Wistar rats showed significant reduction in mean systolic BP by S-SNEDDS vis-à-vis oral suspension (p<0.05) owing to the drug absorption through lymphatic pathways. Solid-state characterization of S-SNEDDS using FT-IR and powder XRD studies confirmed lack of any significant interaction of drug with lipidic excipients and porous carriers. Further, the accelerated stability studies for 6 months revealed that S-SNEDDS are found to be stable without any change in physiochemical properties. Thus, the present studies demonstrated the bioavailability enhancement potential of porous carriers based S-SNEDDS for a BCS class II drug, valsartan.

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Section: Comparative In Vitro Drug Release Studiesmentioning

confidence: 99%

“…The suitability of SMEDDS for bioavailability enhancement of valsartan has already been discussed in the prior art (23). However, in order to understand the relationship between the phase behaviors of the mixture to delineate the nanoemulsion region, more exhaustive study was carried out.…”

Section: Introductionmentioning

confidence: 99%

Development, Optimization, and Characterization of Solid Self-Nanoemulsifying Drug Delivery Systems of Valsartan Using Porous Carriers

et al. 2012

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“…Recently SEDDS have been delivered as liquids absorbed by powders such as colloidal silicon dioxide or microcrystalline cellulose. 57) Thus SEDDS could speciˆcally be utilised for the delivery of oil soluble proteins and peptides requiring minimal preparation conditions.…”

Section: Oil Suspensionsmentioning

confidence: 99%

Lipid Carriers: A Versatile Delivery Vehicle for Proteins and Peptides

2008

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Lipid based carriers have attracted increasing scientiˆc and commercial attention during the last few years as an alternative material for the delivery of peptides and proteins concerned with stability issues. This article presents an overview of diŠerent types of biocompatible and versatile lipid-based carriers employed for the delivery of therapeutic proteins and peptides. Such delivery systems are discussed and exempliˆed regarding both more traditional lipid based delivery systems such as liposomes and lipid emulsions as well as more novel structures, e.g., lipid microtubules, microbubbles, and solid lipid nanoparticles.

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“…SMEDDS with droplets of micron sizes, i.e., lies between 100 -150 nm and SNEDDS with droplets of nanosized between 10-100 nm [5]. Transfer of liquid lipid systems into a solid oral dosage form has been attempted by several methods such as capsule filling and spray drying [6], adsorption onto solid carriers [7][8][9] and melt granulation as well as other techniques [10]. However, a large amount of carrier is required to solidify the liquid, which subsequently results in the production of a large dosage volume [11].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Liquid Loaded Tablets Containing Docetaxel-Self Nano Emulsifying Drug Delivery Systems

Rao¹,

Vidyadhara²,

Sasidhar³

et al. 2015

Trop. J. Pharm Res

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Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients

Cited by 114 publications

References 23 publications

Development, Optimization, and Characterization of Solid Self-Nanoemulsifying Drug Delivery Systems of Valsartan Using Porous Carriers

Development, Optimization, and Characterization of Solid Self-Nanoemulsifying Drug Delivery Systems of Valsartan Using Porous Carriers

Lipid Carriers: A Versatile Delivery Vehicle for Proteins and Peptides

Formulation and Evaluation of Liquid Loaded Tablets Containing Docetaxel-Self Nano Emulsifying Drug Delivery Systems

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