Optimization of a horizontal slot waveguide biosensor to detect DNA hybridization

Viphavakit, Charusluk; Komodromos, Michael; Themistos, Christos; Mohammed, Waleed S.; Kalli, Kyriacos; Rahman, B. M. A.

doi:10.1364/ao.54.004881

Cited by 45 publications

(16 citation statements)

References 34 publications

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“…2 (b)) is carried out. The horizontal slot WG with aqueous solution or air in the slot region, which is designed to be connected with tapered and feed WGs, can be fabricated by controlling the etching process [9]. Here, the horizontal slot height is taken as 100 nm.…”

Section: Resultsmentioning

confidence: 99%

“…To measure the effective index change of a cross-slot WG during the sensing process, this cross-slot WG can be incorporated in a Mach-Zehnder (MZ) interferometer [9]. By introducing the cross-slot WG in one arm of the MZ interferometer through the well-designed adiabatic tapers, and a reference cross-slot WG in the other arm, the relative phase shift, can be obtained from the change in the effective index, , as…”

Section: Resultsmentioning

confidence: 99%

“…Currently, research work on the employment of vertical or horizontal slot WG as a biochemical sensor has been proposed in [8] [9]. For the first time, in this work it is being reported here that by combining a vertical and a horizontal slots it is possible to design and optimize an SOI cross-slot WG for biochemical sensing which can support simultaneously both the polarized waves.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High-Sensitivity Polarization-Independent Biochemical Sensor Based on Silicon-on-Insulator Cross-Slot Waveguide

Pan

Rahman

2017

IEEE J. Select. Topics Quantum Electron.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High-Sensitivity Polarization-Independent Biochemical Sensor Based on Silicon-on-Insulator Cross-Slot Waveguide

Pan

Rahman

2017

IEEE J. Select. Topics Quantum Electron.

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“…Moreover, etching such a narrow vertical slot usually results in a slant sidewall with large roughness, and hence increases the scattering loss [11] and limits the detection sensitivity [12]. Fortunately, these problems can be avoided by using horizontal slot waveguides [13,14]. The horizontal slot waveguides can be fabricated layer by layer and therefore, the slot height can be controlled precisely and smooth interfaces can be realized easily, resulting in low scattering loss in interfaces [15].…”

Section: Introductionmentioning

confidence: 99%

Low-Cost and Highly Sensitive Liquid Refractive Index Sensor Based on Polymer Horizontal Slot Waveguide

Chen

et al. 2019

Photonic Sens

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We analyze and explore the potential of using a polymer horizontal slot waveguide as light-analyte interactive region to implement a low-cost and highly sensitive liquid refractive index sensor. Numerical analysis shows that the optimized polymer horizontal slot waveguide is able to realize high waveguide sensitivity. With the optimized horizontal slot waveguide, polymer liquid refractive index sensors based on Mach-Zehnder interferometer (MZI) and microring resonator (MRR) are then investigated numerically, and the results show that the MZI-based sensor can achieve high sensitivity of 17024 nm/RIU and low limit of detection (LOD) of 1.7610 6 RIU while the MRR-based sensor can achieve the sensitivity of 177 nm/RIU and the LOD of 1.6910 4 RIU with a very small footprint. Compared with the sensors employing conventional silicon or silicon nitride vertical slot waveguide, the sensors employing polymer horizontal slot waveguide exhibit comparable performances but simpler and lower fabrication costs.

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“…We will study the effect of cladding thickness in the presence of ssDNA and dsDNA. The ssDNA and dsDNA refractive indices are taken as 1.456 and 1.53 [15][16][17][18], respectively.…”

mentioning

confidence: 99%

Evolution of Surface Plasmon Supermodes in Metal-Clad Microwire and Its Potential for Biosensing

Aminah

Themistos

Hidayat

et al. 2017

J. Lightwave Technol.

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This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent City Research Online > REPLACE THIS LINE WITH YOUR PAPER IDENTIFICATION NUMBER (DOUBLE-CLICK HERE TO EDIT) < 1 Abstract-A finite element method (FEM) based on the vector H-field formulation in conjunction with perturbation techniques is used to study metal-clad microwire waveguides for bio-sensing applications. Sensors are designed to detect DNA hybridization through the change of the effective index and attenuation constant of the waveguide structure. The key parameters, such as effective index, loss coefficient, and spot-sizes are presented and potential sensor applications are discussed.

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Optimization of a horizontal slot waveguide biosensor to detect DNA hybridization

Cited by 45 publications

References 34 publications

High-Sensitivity Polarization-Independent Biochemical Sensor Based on Silicon-on-Insulator Cross-Slot Waveguide

High-Sensitivity Polarization-Independent Biochemical Sensor Based on Silicon-on-Insulator Cross-Slot Waveguide

Low-Cost and Highly Sensitive Liquid Refractive Index Sensor Based on Polymer Horizontal Slot Waveguide

Evolution of Surface Plasmon Supermodes in Metal-Clad Microwire and Its Potential for Biosensing

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