Optimization of a floating poloxamer 407-based hydrogel using the Box-Behnken design: in vitro characterization and in vivo buoyancy evaluation for intravesical instillation

Goo, Yoon Tae; Yang, Hee Mang; Kim, Chang‐Hyun; Kim, Min Song; Kim, Hyeon Kyun; Chang, In Ho; Choi, Young Wook

doi:10.1016/j.ejps.2021.105885

Cited by 15 publications

(10 citation statements)

References 45 publications

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“…Again, the models were adequate since the F-values were greater than the p-values and the lack-of-fit p-values were non-significant (p > 0.05). [33,41,61] mentioned that a good regression model (one containing squared terms, products of two factors, linear terms, and intercepts) must be significant, the lack-of-fit p-value of the model must also be insignificant, and the coefficient of determination (R 2 ) value of the model should be closer to 1. The results of the present study agreed with the above statements or boundary conditions.…”

Section: Discussionmentioning

confidence: 99%

“…When several processing factors and their interactions are likely to influence the output parameters, the response surface methodology with Box-Behnken Design (BBD) is used to find the optimum processing factors [41][42][43]. The BBD based on the input factors generated 17 experimental runs with five repetitions at the center point.…”

Section: Box-behnken Experimental Design Of Compression Factorsmentioning

confidence: 99%

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Optimizing Uniaxial Oil Extraction of Bulk Rapeseeds: Spectrophotometric and Chemical Analyses of the Extracted Oil under Pretreatment Temperatures and Heating Intervals

et al. 2021

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Optimizing the operating factors in edible oil extraction requires a statistical technique such as a response surface methodology for evaluating their effects on the responses. The examined input factors in this study were the diameter of pressing vessel, VD (60, 80, and 100 mm), temperature, TPR (40, 60, and 80 °C), and heating time, HTM (30, 60 and 90 min). The combination of these factors generated 17 experimental runs where the mass of oil, oil yield, oil extraction efficiency, and deformation energy were calculated. Based on the response surface regression analysis, the combination of the optimized factors was VD: 100 (+1) mm; TPR: 80 °C (+1) and HTM: 60 (0) min); VD: 60 (−1) mm; TPR: 80 °C (+1) and HTM: 75 (+0.5) min and VD: 100 (+1) mm; TPR: 80 °C (+1) and HTM: 90 (+1). The absorbance and transmittance values significantly (p < 0.05) correlated with the wavelength and temperature, but they did not correlate significantly (p > 0.05) with heating time. The peroxide value did not correlate significantly with temperature, however, it correlated significantly with heating time. Neither the acid value nor the free fatty acid value correlated with both temperature and heating time. The findings of the present study are part of our continuing research on oilseeds’ processing optimization parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Box-behnken Experimental Design Of Compression Factorsmentioning

confidence: 99%

Optimizing Uniaxial Oil Extraction of Bulk Rapeseeds: Spectrophotometric and Chemical Analyses of the Extracted Oil under Pretreatment Temperatures and Heating Intervals

et al. 2021

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“…The gel had a duration of nearly 400 minutes. 93 However, the decomposition of sodium bicarbonate to produce carbon dioxide required acidic conditions. This meant that patients had to take oral medications like ammonium chloride and vitamin C to acidify their urine.…”

Section: Applications Of Hydrogel-based Drugs For Intravesical Instil...mentioning

confidence: 99%

Hydrogel: a new material for intravesical drug delivery after bladder cancer surgery

Wu,

Gu,

Chen

et al. 2024

J. Mater. Chem. B

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“…The hydrogel demonstrated prolonged residence time and continuous drug release for up to 10 h when tested in vivo using a rabbit acute bladder injury model . Several other hydrogels investigated for use as intravesical drug delivery systems and therapeutic bulking agents were reported as promising drug delivery systems for treating urinary bladder disorders. − …”

Section: Mucosal Tissuesmentioning

confidence: 99%

Hydrogels for Mucosal Drug Delivery

Yeruva

Yang

Doski

et al. 2023

ACS Appl. Bio Mater.

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Mucosal tissues are often a desirable site of drug action to treat disease and engage the immune system. However, systemically administered drugs suffer from limited bioavailability in mucosal tissues where technologies to enable direct, local delivery to these sites would prove useful. In this Spotlight on Applications article, we discuss hydrogels as an attractive means for local delivery of therapeutics to address a range of conditions affecting the eye, nose, oral cavity, gastrointestinal, urinary bladder, and vaginal tracts. Considering the barriers to effective mucosal delivery, we provide an overview of the key parameters in the use of hydrogels for these applications. Finally, we highlight recent work demonstrating their use for inflammatory and infectious diseases affecting these tissues.

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Optimization of a floating poloxamer 407-based hydrogel using the Box-Behnken design: in vitro characterization and in vivo buoyancy evaluation for intravesical instillation

Cited by 15 publications

References 45 publications

Optimizing Uniaxial Oil Extraction of Bulk Rapeseeds: Spectrophotometric and Chemical Analyses of the Extracted Oil under Pretreatment Temperatures and Heating Intervals

Optimizing Uniaxial Oil Extraction of Bulk Rapeseeds: Spectrophotometric and Chemical Analyses of the Extracted Oil under Pretreatment Temperatures and Heating Intervals

Hydrogel: a new material for intravesical drug delivery after bladder cancer surgery

Hydrogels for Mucosal Drug Delivery

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