Optimization of a chemooptical surface plasmon resonance based sensor

Gent, J. van; Lambeck, Paul; Kreuwel, Harrie; Gerritsma, G.J.; Sudhölter, Ernst J. R.; Reinhoudt, David N.; Popma, T.J.A.

doi:10.1364/ao.29.002843

Cited by 91 publications

(31 citation statements)

References 7 publications

(5 reference statements)

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“…This enabled us to calculate SPR curves, estimate SPR response from protein immobilization and estimate changes in dielectric permittivity. We consider a structure with five layers: layer 1 consists of a prism with dielectric permittivity ε 1 =2.30, layer 2 consists of a gold film of thickness d 2 =47 nm with complex permittivityε 2 = −13.2 + i1.25 , layer 3 consists of a dextran layer filled with high relaxation (HR) solution of thickness d 3 =140 nm [22] and ε 3 =1.78 in the case of the sarcomeres, and with buffer in the case of tubulin, layer 4 consists of our sample medium (sarcomeres or tubulin) with thickness d 4 and layer 5 consists of only solution. The fifth layer is assumed to be semi-infinite with respect to surface plasmon penetration depth.…”

Section: Theoretical Modelmentioning

confidence: 99%

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Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

Schuessler

Mershin²,

Kolomenskii

et al. 2003

Journal of Modern Optics

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Biosensors based on the principle of surface plasmon resonance (SPR) detection were used to measure biomolecular interactions in sarcomeres and changes of the dielectric constant of tubulin samples with varying concentration. At SPR, photons of laser light efficiently excite surface plasmons propagating along a metal (gold) film. This resonance manifests itself as a sharp minimum in the reflection of the incident laser light and occurs at a characteristic angle.The dependence of the SPR angle on the dielectric permittivity of the sample medium adjacent to the gold film allows the monitoring of molecular interactions at the surface. We present results of measurements of cross-bridge attachment/detachment within intact mouse heart muscle sarcomeres and measurements on bovine tubulin molecules pertinent to cytoskeletal signal transduction models.

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Section: Theoretical Modelmentioning

confidence: 99%

“…Practical applications of the SPR method include chemical sensors [3,4] and biosensors [5]. Specifically, the SPR technique is by now a well-established method for the analysis of interactions among biomolecules [6].…”

Section: Introductionmentioning

confidence: 99%

Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

Schuessler

Mershin²,

Kolomenskii

et al. 2003

Journal of Modern Optics

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show abstract

“…Change in refractive index changes the value of the resonance parameter. To excite surface plasmons, generally, a prism is used [2][3][4][5][6][7][8][9]. The prism-based SPR sensing device has a number of shortcomings such as its bulky size and the presence of various optical and mechanical (moving) parts.…”

Section: Introductionmentioning

confidence: 99%

Surface Plasmon Resonance‐Based Fiber Optic Sensors: Principle, Probe Designs, and Some Applications

2009

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Surface plasmon resonance technique in collaboration with optical fiber technology has brought tremendous advancements in sensing of various physical, chemical, and biochemical parameters. In this review article, we present the principle of SPR technique for sensing and various designs of the fiber optic SPR probe reported for the enhancement of the sensitivity of the sensor. In addition, we present few examples of the surface plasmon resonance-(SPR-) based fiber optic sensors. The present review may provide researchers valuable information regarding fiber optic SPR sensors and encourage them to take this area for further research and development.

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“…Practical applications of the SPR method include chemical sensors [128,129] and biosensors [130]. Specifically, the SPR technique is by now a well-established method for the analysis of interactions among biomolecules [131].…”

Section: Surface Plasmon Resonance (Spr) 431 Spr Basicsmentioning

confidence: 99%

Towards Experimental Tests of Quantum Effects in Cytoskeletal Proteins

Mershin

Sanabria

Miller

et al.

The Emerging Physics of Consciousness

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PREFACEThis volume is appropriately titled "The Emerging Physics of Consciousness" and much of it is focused on using some aspect of "quantum weirdness" to solve the problems associated with the phenomenon of consciousness. This is sometimes done in hopes that perhaps the two mysteries will somehow cancel each other through such phenomena as quantum coherence and entanglement or superposition of wavefunctions. We are not convinced that such a cancellation can take place. In fact, finding that quantum phenomena are involved in consciousness, what we will call the "Quantum Consciousness Idea" (QCI) (fathered largely by Penrose and Hameroff [1][2][3]), is likely to confound both mysteries and is of great interest.In our contribution, we want to emphasize the "Emerging" part of this volume's title by pointing out that there is a glaring need for properly controlled and reproducible experimental work if any proposed quantum phenomena in biological matter, let alone consciousness are to be taken seriously.There are three broad kinds of experiments that one can devise to test hypotheses involving the relevance of quantum effects to the phenomenon of consciousness. The three kinds address three different scale ranges associated roughly with tissue-to-cell (1cm-10µm), cell-toprotein (10µm-10nm) and protein-to-atom (10nm-1Å) sizes. Note that we are excluding experiments that aim to detect quantum effects at the "whole human" or even "society" level as these have consistently given either negative results or been plagued by irreproducibility and bad science (e.g. the various extra sensory perception and remote viewing experiments [4]).The consciousness experiments belonging to the tissue-cell scale frequently utilize apparatus such as electro-encephalographs (EEG) or magnetic resonance imaging (MRI) to track

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Optimization of a chemooptical surface plasmon resonance based sensor

Abstract: A surface plasmon based chemooptical sensor has been optimized by the use of computer simulation programs. Calculated and experimentally measured performances are in good agreement, showing the value of the simulation tool.

Cited by 91 publications

References 7 publications

Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

Surface plasmon resonance study of the actin-myosin sarcomeric complex and tubulin dimers

Surface Plasmon Resonance‐Based Fiber Optic Sensors: Principle, Probe Designs, and Some Applications

Towards Experimental Tests of Quantum Effects in Cytoskeletal Proteins

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