Optimization of a CE-ICP-MS/MS method for the investigation of liposome–cisplatin nanosystems and their interactions with transferrin

Abstract

As chemotherapy suffers the limitations of the non-selectivity toward cancer cells resulting in severe side effects, the targeted delivery of anticancer drugs (such as cisplatin) using nontoxic nanomaterials is under...

Atomic spectrometry update: review of advances in elemental speciation

“…Two papers related to the analysis of Pt-containing chemotherapeutic agents have been reported, each dealing with a different aspect of metallodrug analysis, including the drug delivery system and impurities in the drug preparations. Wroblewska et al 102 has focused on the use of a CE-ICP-MS/MS method for the investigation of liposome–cisplatin nanosystems and their interactions with transferrin. Drug targeting can reduce the systemic toxicity of drugs such as cisplatin and improve treatment efficacy, by improving tumour uptake.…”

Review: Sulfur Analysis using Inductively Coupled Plasma Mass Spectrometry

“…60 Liposome-cisplatin nanosystems and their interactions with transferrin were investigated using CE-ICP-MS/MS by measuring 31 P 16 O + for liposomes, 32 S 16 O + for proteins, and 195 Pt + for drugs (cisplatin). 99 GC-ICP-QMS was used to analyze volatile organic sulfur species from human cadavers and environmental samples. 91,113 Notably, 1 L of odor sample was actively drawn from a human cadaver at a sampling rate of 100 mL/min through a dual sorbent tube and collected in 1 mL of solution for analysis, that is, an enrichment factor of 1000-fold was achieved for the volatile organic species.…”