Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology

Vichasilp, Chaluntorn; Nakagawa, Kiyotaka; Sookwong, Phumon; Suzuki, Yasuyo; Kimura, Fumiko; Higuchi, Ohki; Miyazawa, Teruo

doi:10.1271/bbb.90543

Cited by 38 publications

(20 citation statements)

References 20 publications

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“…After optimization of the mulberry leaf harvesting, drying, and extraction processes, we produced food-grade mulberry powder enriched with DNJ (approximately 1.0%). [7][8][9] Studies in human subjects indicated that this DNJ-enriched powder lowered blood sugar levels (Fig. 1C).…”

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confidence: 89%

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Studies Targeting α-Glucosidase Inhibition, Antiangiogenic Effects, and Lipid Modification Regulation: Background, Evaluation, and Challenges in the Development of Food Ingredients for Therapeutic Purposes

Nakagawa

2013

Bioscience, Biotechnology, and Biochemistry

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confidence: 89%

“…[3][4][5][6] By these methods, it was confirmed that DNJ content in mulberry products is relatively low, approximately 0.1% (100 mg/100 g dry product), and that some products contain only trace amounts of DNJ. 3,7) Thus, if DNJ-enriched products can be produced, its pharmacological administration offers a potential therapeutic approach to diabetes prevention.…”

mentioning

confidence: 99%

Studies Targeting α-Glucosidase Inhibition, Antiangiogenic Effects, and Lipid Modification Regulation: Background, Evaluation, and Challenges in the Development of Food Ingredients for Therapeutic Purposes

Nakagawa

2013

Bioscience, Biotechnology, and Biochemistry

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“…Alkaloids, widely distributed in various parts of the plant, often concentrated on a particular organ, are a class of nitrogen‐containing organic compounds derived from the biosphere. Alkaloids are the effective ingredients in many medicinal plants with special and significant physiological activity . Common alkaloids used in anti‐obesity research include piperine, matrine, berberine (Supporting Information http://onlinelibrary.wiley.com/doi/10.1111/obr.12228/suppinfo).…”

Section: Active Ingredients From Traditional Chinese Medicinementioning

confidence: 99%

Active ingredients from natural botanicals in the treatment of obesity

2014

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Obesity is considered as a chronic disease that can induce a series of comorbidities and complications. Chinese medicine has long clinical experiences in the treatment of obesity. This review summarizes the natural products from traditional Chinese medicine (TCM) that are reported to have anti-obesity effects in the past two decades. Botanic TCM comprises 90% of total Chinese crude drugs, and generally contains various active ingredients, in which the effective anti-obesity ingredients identified can be divided into saponins, polysaccharides, alkaloids, polyphenols and others. Astragaloside IV, glycyrrhizin, macrostemonoside A, berberine, betaine, capsaicin, matrine, methyl piperate, piperine, rutaecarpine, asimilobine, epigallocatechingallate, magnolol, resveratrol, soybean-isoflavone, α-linolenic acid, emodin, geniposide, phillyrin, salidroside and ursolic acid are specified in this review, and their sources, models, efficacy are described. It is concluded that the mechanisms of these components for the treatment of obesity include: (i) suppression of appetite, increase of satiety, reduction of energy intake; (ii) reduction in the digestion and absorption of exogenous lipid; (iii) attenuation of the synthesis of endogenous lipid; (iv) promotion of the oxidation and expenditure of lipid and (v) improvement of lipid metabolism disorder. Authors believe that the effective compounds from TCM will provide an alternative and hopeful way for the treatment of obesity.

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“…[151617] Studies on human beings have revealed that a 1-DNJ–enriched FM preparation is an effective hypoglycemic agent in control and type 2 DM patients. [918] However, a limited number of studies have been conducted on the hypoglycemic activity of purified 1-DNJ in diabetic animals.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats

Huang

Yan

et al. 2014

Journal of Traditional and Complementary Medicine

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Folium mori (桑葉 Sāng Yè, leaf of Morus alba L.; FM) is known to possess hypoglycemic effects, and 1-deoxynojirimycin (1-DNJ) has been proposed as an important functional compound in FM. However, the hypoglycemic activity of purified 1-DNJ has been rarely studied. It is also not known how FM and 1-DNJ affect the development of DM nephropathy. This study compared the antidiabetic effect of a commercial FM product with that of purified 1-DNJ in streptozotocin-induced diabetic rats. Seven days after induction, the diabetic rats were gavaged with FM (1, 3, 10, and 30 mg/kg/day), 1-DNJ (30 mg/kg/day), or vehicle (distilled deionized water; 2 ml/kg/day) for 7 days. All doses of FM ameliorated fasting and post-prandial blood glucose concomitantly with an increase in peripheral and pancreatic levels of insulin and improved homeostasis model assessment (HOMA-IR) in diabetic rats in a dose-dependent manner. Increased thiobarbituric acid reactive substances (TBARS) and nitrate/nitrite levels in the kidney, liver, and muscle of diabetic rats were reversed by all doses of FM. The renal function of the diabetic rats was normalized by all doses of FM, while blood pressure changes were reversed by FM at doses of 3 mg/kg and above. Moreover, most of the above-mentioned parameters were improved by FM at doses of 3 mg/kg and above to a similar extent as that of 1-DNJ. The results showed superior antidiabetic potential of the commercial FM product for glycemic control and protection against the development of diabetic nephropathy.

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Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology

Cited by 38 publications

References 20 publications

Studies Targeting α-Glucosidase Inhibition, Antiangiogenic Effects, and Lipid Modification Regulation: Background, Evaluation, and Challenges in the Development of Food Ingredients for Therapeutic Purposes

Studies Targeting α-Glucosidase Inhibition, Antiangiogenic Effects, and Lipid Modification Regulation: Background, Evaluation, and Challenges in the Development of Food Ingredients for Therapeutic Purposes

Active ingredients from natural botanicals in the treatment of obesity

A Comparison of Food-grade Folium mori Extract and 1-Deoxynojirimycin for Glycemic Control and Renal Function in Streptozotocin-induced Diabetic Rats

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