Optimization for high-dose-rate brachytherapy of cervical cancer with adaptive simulated annealing and gradient descent

Yao, Rui; Templeton, A; Liao, Yixiang; Turian, J; Kiel, Krystyna; Chu, James C.H.

doi:10.1016/j.brachy.2013.10.013

Cited by 9 publications

(13 citation statements)

References 20 publications

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“…Yao et al. explored the use of gEUD as an inverse optimization objective function 45. The D2cc EQD2 OAR values are used as OAR plan evaluation metrics based upon the recommendations of the GEC‐ESTRO working group,5, 7 the EMBRACE protocol,10 and ICRU report #8911 that assumes that D2cc EQD2 HDR values or pulse dose rate (PDR) BT plans represent the full dose distribution (DVH) of each OAR reasonably well.…”

Section: Resultsmentioning

confidence: 99%

Patient's specific integration of OAR doses (D2 cc) from EBRT and 3D image‐guided brachytherapy for cervical cancer

Gelover

Katherine

Mart

et al. 2018

J Applied Clin Med Phys

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The objective of this study was to assess the recommended DVH parameter (e.g., D2 cc) addition method used for combining EBRT and HDR plans, against a reference dataset generated from an EQD2‐based DVH addition method. A revised DVH parameter addition method using EBRT DVH parameters derived from each patient's plan was proposed and also compared with the reference dataset. Thirty‐one biopsy‐proven cervical cancer patients who received EBRT and HDR brachytherapy were retrospectively analyzed. A parametrial and/or paraaortic EBRT boost were clinically performed on 13 patients. Ten IMRT and 21 3DCRT plans were determined. Two different HDR techniques for each HDR plan were analyzed. Overall D2 cc and D0.1 cc OAR doses in EQD2 were statistically analyzed for three different DVH parameter addition methods: a currently recommended method, a proposed revised method, and a reference DVH addition method. The overall D2 ccEQD 2 values for all rectum, bladder, and sigmoid for a conformal, volume optimization HDR plan generated using the current DVH parameter addition method were significantly underestimated on average −5 to −8% when compared to the values obtained from the reference DVH addition technique (P < 0.01). The revised DVH parameter addition method did not present statistical differences with the reference technique (P > 0.099). When PM boosts were considered, there was an even greater average underestimation of −8~−10% for overall OAR doses of conformal HDR plans when using the current DVH parameter addition technique as compared to the revised DVH parameter addition. No statistically significant differences were found between the 3DCRT and IMRT techniques (P > 0.3148). It is recommended that the overall D2 cc EBRT doses are obtained from each patient's EBRT plan.

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Section: Resultsmentioning

confidence: 99%

Patient's specific integration of OAR doses (D2 cc) from EBRT and 3D image‐guided brachytherapy for cervical cancer

Gelover

Katherine

Mart

et al. 2018

J Applied Clin Med Phys

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“…The index gEUD is also used in an optimization model for cervical cancer. 93 In both these HDR BT studies, the objective function used is the gEUD formulation 21 proposed in the context of IMRT. Equation (14) shows this formulation using the notation given in Tables II and VII.…”

Section: E1 Eud Modelsmentioning

confidence: 99%

“…Furthermore, it is observed that overdosage of the tumor has only a small impact on the gEUD, while it is very sensitive to underdosing of the tumor. 93 There has been a larger interest in optimization models based on gEUD in IMRT, possibly because nonlinear models are more common in IMRT, while linear models such as the LPM and the DVM are more common in HDR BT.…”

Section: E1 Eud Modelsmentioning

confidence: 99%

Optimization in treatment planning of high dose‐rate brachytherapy — Review and analysis of mathematical models

2021

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Treatment planning in high dose-rate brachytherapy has traditionally been conducted with manual forward planning, but inverse planning is today increasingly used in clinical practice. There is a large variety of proposed optimization models and algorithms to model and solve the treatment planning problem. Two major parts of inverse treatment planning for which mathematical optimization can be used are the decisions about catheter placement and dwell time distributions. Both these problems as well as integrated approaches are included in this review. The proposed models include linear penalty models, dose-volume models, mean-tail dose models, quadratic penalty models, radiobiological models, and multiobjective models. The aim of this survey is twofold: (i) to give a broad overview over mathematical optimization models used for treatment planning of brachytherapy and (ii) to provide mathematical analyses and comparisons between models. New technologies for brachytherapy treatments and methods for treatment planning are also discussed. Of particular interest for future research is a thorough comparison between optimization models and algorithms on the same dataset, and clinical validation of proposed optimization approaches with respect to patient outcome.

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“…A more homogeneous dose distribution with respect to COIN is also obtained. The index gEUD is also used in an optimization model in [112]. In both these BT studies, the objective function used is the gEUD formulation that was proposed in the context of IMRT in [110].…”

Section: Radiobiological Modelsmentioning

confidence: 99%

“…Equation (3.7) shows this formulation using the notation given in Table 3.6. Survival probability of the tumour cells, with t = 0 it gives the initial probability Furthermore, in [112] it is observed that overdosage of the tumour has only a small impact on the gEUD while gEUD is very sensitive to underdosing of the tumour. In IMRT there has been a larger interest in the optimization models based on gEUD, possibly because non-linear models are more common in IMRT, while linear models, such as the LPM and the DVM, are more common in HDR BT.…”

Section: Radiobiological Modelsmentioning

confidence: 99%

Mathematical Modelling of Dose Planning in High Dose-Rate Brachytherapy

Morén

2019

Linköping Studies in Science and Technology. Licentiate Thesis

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Optimization for high-dose-rate brachytherapy of cervical cancer with adaptive simulated annealing and gradient descent

Cited by 9 publications

References 20 publications

Patient's specific integration of OAR doses (D2 cc) from EBRT and 3D image‐guided brachytherapy for cervical cancer

Patient's specific integration of OAR doses (D2 cc) from EBRT and 3D image‐guided brachytherapy for cervical cancer

Optimization in treatment planning of high dose‐rate brachytherapy — Review and analysis of mathematical models

Mathematical Modelling of Dose Planning in High Dose-Rate Brachytherapy

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