Optimization and validation of low‐field MP2RAGE T1 mapping on 0.35T MR‐Linac: Toward adaptive dose painting with hypoxia biomarkers
Claire Keun Sun Park,
Noah Stanley Warner,
Evangelia Kaza
et al.
Abstract:BackgroundStereotactic MR‐guided Adaptive Radiation Therapy (SMART) dose painting for hypoxia has potential to improve treatment outcomes, but clinical implementation on low‐field MR‐Linac faces substantial challenges due to dramatically lower signal‐to‐noise ratio (SNR) characteristics. While quantitative MRI and T1 mapping of hypoxia biomarkers show promise, T1‐to‐noise ratio (T1NR) optimization at low fields is paramount, particularly for the clinical implementation of oxygen‐enhanced (OE)‐MRI. The 3D Magne… Show more
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